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This study demonstrated that a significant decrease in the protein level of GluA1 in major depression disorder.
The findings do not support the association of GRIA1 SNPs with schizophrenia in the Chinese Han population.
Our data of this study confirmed the association of GRIA1 (rs2195450) to female migraine susceptibility in the Chinese Han population.
Polymorphisms in GRIA1 gene are a risk factor for asparaginase hypersensitivity during the treatment of childhood acute lymphoblastic leukemia
The level of phosphorylated GluA1 at S831 and S845, two major sites implicated in AMPAR regulation, is almost negligible. Results impel us to reconsider the mechanisms underlying synaptic plasticity.
This study failed to replicate previously reported association between GRIA1 rs548294 and migraine without aura (zeige AURKA Proteine), either as single marker or when analyzed in haplotype combination with rs2195450.
the levels were comparable for complexes containing GluR2 (zeige GRIA2 Proteine), GluR3 (zeige GRIA3 Proteine) and GluR4 (zeige GRIA4 Proteine) as well as 5-HT1A (zeige HTR1A Proteine). Moreover, the levels of complexes containing muscarinic AChR M1, NR1 (zeige GRIN1 Proteine) and GluR1 were significantly increased in male patients with AD.
The N-terminal domain modulates alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA (zeige GRIA3 Proteine)) receptor desensitization.
insight into the structure and function of the C-terminal domain of GluA1, which controls AMPA (zeige GRIA3 Proteine) receptor function and trafficking during synaptic plasticity in the central nervous system.
Inhibition of CREB (zeige CREB1 Proteine) function is associated with a specific reduction of AMPA (zeige GRIA3 Proteine) receptor subunit GluA1.
Presynaptic (CA3 (zeige CA3 Proteine) pyramidal cell), but not postsynaptic (CA1 (zeige CA1 Proteine) pyramidal cell), deletion of N-methyl-d-aspartate (NMDA)-type glutamate (zeige GRIN1 Proteine) receptors eliminated the ketamine-induced enhancement of excitatory synaptic transmission in hippocampal slices and the antidepressant actions of ketamine
In the present study, by combining a 64-channel multielectrode system and a novel analysis and visualization method, we observed the accurate spatial localization and dynamic temporal changes of network fEPSP signals and LTP responses within the ACC circuit and found that PKA phosphorylation, but not PKC phosphorylation, of the GluA1 is required for LTP in the ACC.
Data suggest that phosphorylation of Shp2/Ptpn11 (zeige PTPN11 Proteine) at Tyr542 and its translocation to postsynaptic compartment are integral processes in synaptic scaling/homeostasis; Shp2 (zeige PTPN11 Proteine) phosphatase activity is critical to regulation of Ser (zeige SIGLEC1 Proteine)(P)845 GluA1 and surface expression of GluA1 during synaptic scaling. (Shp2/Ptpn11 (zeige PTPN11 Proteine) = protein tyrosine phosphatase non-receptor type 11 (zeige PTPN11 Proteine); GluA1 = glutamate receptor ionotropic Ampa1 [alpha 1])
Gria1 expression in Purkinje cells is not required for cerebellar motor learning.
Three epilepsy-associated missense mutations reduce neural precursor cell expressed developmentally down-regulated gene 4 (zeige NEDD4 Proteine)-2 (Nedd4-2 (zeige NEDD4L Proteine))-mediated AMPA (zeige GRIA3 Proteine) receptor GluA1 ubiquitination.
Chronic stress-elicited depressive behavior may be due to hypertrophy of basolateral amygdala (BLA (zeige LACTB Proteine)) neuronal dendrites and increased of Glur1-Glur2 (zeige GRIA2 Proteine) ratio in BLA (zeige LACTB Proteine) neurons.
Study demonstrated that naltrexone-induced plasticity in excitatory synapses, via the transitory increase of GluA1 insertion at the postsynaptic density and GluA1-S845 phosphorylation, facilitates learning
Although dephosphorylation of Serine 845 is thought to have a key role in long term depression (LTD), results indicate that few GluA1 subunits in hippocampal neurons are phosphorylated at this site. In contrast, approximately 50% of GluA1 subunits are phosphorylated at threonine 840, suggesting that dephosphorylation of this site can contribute to the down-regulation of AMPAR-mediated synaptic transmission in LTD.
Information load regulates AMPA (zeige GRIA3 Proteine)-R phosphorylation within the hippocampus, and an overload condition associated with impaired memory is paralleled by a lack of AMPA (zeige GRIA3 Proteine)-R phosphorylation.
The findings of this study suggested that phosphorylation of GluA1 at S831 plays an important role in the development of hypersensitivity after SCL (zeige TAL1 Proteine).
the intracellularly located CTD of GLUR1 is the origin of TARP-specific functional modulation and not merely a facilitator of trafficking
We also assessed ionotropic glutamate (zeige GRIN2A Proteine) receptor GLR-1 cell-specifically within AIB and determined that GLR-1 fine-tunes AIB activity to modify locomotion following reversal events. Our research highlights that signal integration underlying the initiation and fine-tuning of backwards locomotion is AIB and NPR (zeige NPTXR Proteine)-9 dependent, and has demonstrated the suitability of C. elegans for analysis of multisensory integration
We propose a model in which synaptic activity regulates the nuclear localization of CMK-1 to mediate a negative feedback mechanism coupling GLR-1 activity with its own transcription.
Mutants lacking p38 MAPK (zeige MAPK14 Proteine) components pmk (zeige PMVK Proteine)-1 or sek-1 (zeige MAP2K4 Proteine) resemble mutants lacking the hypoxia response component and prolyl hydroxylase egl-9, with impaired subcellular localization of Mint orthologue LIN-10, internalization of glutamate (zeige GRIN2A Proteine) receptor GLR-1, and depression of GLR-1-mediated behaviors.
KEL-8 is a substrate receptor for Cullin 3 ubiquitin ligases that is required for the proteolysis of GLR-1 receptors and suggest a novel postmitotic role in neurons for Kelch/CUL3 ubiquitin ligases.
WDR-20 and WDR-48 form a complex with USP-46 and stimulate the DUB to deubiquitinate and stabilize GLR-1 in vivo.
glr-1 is required for long-term memory for habituation and memory for context conditioning.
Study indicates kinesin KLP-4 as a novel regulator of anterograde GLR-1 glutamate (zeige GRIN2A Proteine) receptors trafficking and reveals a cellular control mechanism by which receptor cargo is targeted for degradation in tje absence of its motor.
An auxiliary protein SOL-2, a CUB-domain protein, associates with both the related auxiliary subunit SOL-1 and with the GLR-1 AMPA (zeige GRIA3 Proteine) receptor.
UEV-1 could regulate a small subset of K63-linked ubiquitination events in nematodes, at least one of which is critical in regulating GLR-1 trafficking
Long-term memory in C. elegans is dependent on glr-1 and likely involves changes in the expression or localization of glutamate (zeige GRIN2A Proteine) receptors
Glutamate receptors are the predominant excitatory neurotransmitter receptors in the mammalian brain and are activated in a variety of normal neurophysiologic processes. These receptors are heteromeric protein complexes with multiple subunits, each possessing transmembrane regions, and all arranged to form a ligand-gated ion channel. The classification of glutamate receptors is based on their activation by different pharmacologic agonists. This gene belongs to a family of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate (AMPA) receptors. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.
, AMPA-selective glutamate receptor 1
, glutamate receptor 1
, glutamate receptor A
, glutamate receptor subunit GluR1
, glutamate receptor, ionotropic, AMPA1 (alpha 1)
, glutamate receptor ionotropic, AMPA 1
, AMPA glutamate receptor
, glutamate receptor, ionotropic, AMPA 1
, GluR1 protein