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anti-Human DEPTOR Antikörper:
anti-Mouse (Murine) DEPTOR Antikörper:
anti-Rat (Rattus) DEPTOR Antikörper:
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Human Polyclonal DEPTOR Primary Antibody für ICC, IF - ABIN4304935
Jegg, Ward, Iorns, Hoe, Zhou, Liu, Singh, Landgraf, Pegram: PI3K independent activation of mTORC1 as a target in lapatinib-resistant ERBB2+ breast cancer cells. in Breast cancer research and treatment 2012
Show all 8 Pubmed References
Human Polyclonal DEPTOR Primary Antibody für IF (p), IHC (p) - ABIN1387597
Liu, Zhang, Liu, Li, Zhang, Li, Liu, Huang, Shen, Gu, Gao, Wu, Wu: High DEPTOR expression correlates with poor prognosis in patients with esophageal squamous cell carcinoma. in OncoTargets and therapy 2015
DEPTOR overexpression is associated with cervical squamous cell carcinoma.
Studies provide evidence that Deptor appears to play an important role in the pathogenesis of many types of cancers, mainly through its role in controlling the activity of mTOR (zeige FRAP1 Antikörper) and many other possible functions. [review]
Low DEPTOR expression is associated with esophageal squamous cell carcinoma.
Association between insulin (zeige INS Antikörper) sensitivity and genetic variants in DEPTOR gene suggest DEPTOR and mammalian target of rapamycin (zeige FRAP1 Antikörper) signaling pathway to be potential target for future research and pharmacological interventions.
High DEPTOR expression is associated with T-cell leukemia.
Results provide evidence that DEPTOR acts as a tumor suppressor by limiting EGFR (zeige EGFR Antikörper)-driven lung adenocarcinoma progression.
that DEPTOR expression is required to maintain myeloma cell differentiation and high level of its expression are associated with better outcome.
High expression of DEPTOR benefits esophageal squamous cell carcinoma patients in early stage but not advanced stage.
the present findings supported the fact that DEPTOR-mTOR (zeige FRAP1 Antikörper) signaling is a central regulator of lipid metabolism-mediated inflammation in lymphocytes of PBMC culture.
In this study we began by validating the expression of four main mTOR (zeige FRAP1 Antikörper) pathway components, mTOR (zeige FRAP1 Antikörper), DEPTOR, rictor (zeige RICTOR Antikörper) and raptor (zeige RPTOR Antikörper), at gene and protein level in in vitro models of endometrioid (MDAH2774) and clear cell (SKOV3) ovarian cancer
Cul-1 (zeige CUL1 Antikörper) deneddylation led to Deptor accumulation and subsequent mTOR (zeige FRAP1 Antikörper) inactivation, which had an inhibitory effect on dendritic cells in mouse model of inflammatory bowel disease.
These results support the idea that other neuronal populations are responsible for these phenotypes. Nonetheless, we observed a mild elevation in fasting blood glucose, insulin (zeige INS Antikörper) resistance, and alterations in liver glucose and lipid homeostasis in mice overexpressing DEPTOR in POMC (zeige POMC Antikörper) neurons. Taken together, these results show that DEPTOR overexpression in POMC (zeige POMC Antikörper) neurons does not affect energy balance regulation but could modu
The present study indicates that regulation of DEPTOR/mTOR (zeige FRAP1 Antikörper) signaling may be an important mechanism for glutamine (zeige GFPT1 Antikörper) in prevention against the development of colitis-associated colorectal cancer (CAC (zeige SLC25A20 Antikörper)): the chemopreventive effect of dietary glutamine (zeige GFPT1 Antikörper) on CAC (zeige SLC25A20 Antikörper) is, at least in part, associated with the induction of autophagy.
DEPTOR regulates liver inflammation at least partially via mTORC1 pathway, and is down-regulated by lypopolysaccharides through p65 (zeige NFkBP65 Antikörper).
p38gamma (zeige MAPK12 Antikörper) and p38delta (zeige MAPK1/3 Antikörper) control heart growth by modulating mTOR (zeige FRAP1 Antikörper) pathway through DEPTOR phosphorylation and subsequent degradation.
DEPTOR plays a key role in maintaining stem cell pluripotency by limiting mTOR (zeige FRAP1 Antikörper) activity in undifferentiated embryonic stem cells
DEPTOR is induced by glucocorticoids during adipogenesis and that its overexpression promotes, while its suppression blocks, adipogenesis.
Data show that knockdown reduced Deptor mRNA and protein content by 90%, which increased phosphorylation of mTOR (zeige FRAP1 Antikörper) kinase substrates, 4E-BP1 (zeige EIF4EBP1 Antikörper) and S6K1 (zeige RPS6KB1 Antikörper), and concomitantly increased protein synthesis.
Negative regulator of the mTORC1 and mTORC2 signaling pathways. Inhibits the kinase activity of both complexes (By similarity).
DEP domain containing MTOR-interacting protein
, DEP domain containing 6
, DEP domain containing mTOR interacting protein
, DEP domain-containing mTOR-interacting protein
, DEP domain-containing protein 6
, Rap guanine nucleotide exchange factor (GEF) 4