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Our findings suggest that alteration of p16, p14, p27, p21, and p53 status may contribute to carcinogenesis and the clinical behavior of HPV-negative adenocarcinoma of the uterine cervix
antitumor effects of DOC-1R may be mediated by negatively regulating G1 phase progression and G1/S transition through inhibiting CDK2 expression and activation
Cdk2ap2 under normal conditions has a biphasic expression, suggesting regulatory roles in early-versus-late stem cell differentiation.
cyclin-dependent kinase 2-associated protein 1 (CDK2AP1), an essential gene for early embryonic development, plays a role in pluripotency of ESC by engaging MBD3 to the promoter region of Wnt signaling genes
Mouse DOC-1R gene can significantly inhibit cell growth and colony formation capacity.
identified a mitogen-activated protein kinase partner, DOC1R, a murine homologue of a potential human tumor suppressor gene; characterized DOC1R during mouse oocyte meiosis resumption
This gene encodes a protein that interacts with cyclin-dependent kinase 2 associated protein 1. Pseudogenes associated with this gene are located on chromosomes 7 and 9. Alternatively spliced transcript variants have been observed for this gene.
CDK2-associated protein 2
, DOC-1-related protein
, cyclin-dependent kinase 2-associated protein 2
, tumor suppressor deleted in oral cancer related 1
, tumor suppressor deleted in oral cancer-related 1
, DOC-1 related protein