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Our findings suggest that alteration of p16, p14 (zeige S100A9 Proteine), p27 (zeige PAK2 Proteine), p21 (zeige CDKN1A Proteine), and p53 (zeige TP53 Proteine) status may contribute to carcinogenesis and the clinical behavior of HPV-negative adenocarcinoma of the uterine cervix
antitumor effects of DOC-1R may be mediated by negatively regulating G1 phase progression and G1/S transition through inhibiting CDK2 (zeige CDK2 Proteine) expression and activation
Cdk2ap2 under normal conditions has a biphasic expression, suggesting regulatory roles in early-versus-late stem cell differentiation.
cyclin-dependent kinase 2-associated protein 1 (CDK2AP1 (zeige CDK2AP1 Proteine)), an essential gene for early embryonic development, plays a role in pluripotency of ESC by engaging MBD3 (zeige MBD3 Proteine) to the promoter region of Wnt (zeige WNT2 Proteine) signaling genes
Mouse DOC-1R gene can significantly inhibit cell growth and colony formation capacity.
identified a mitogen-activated protein kinase (zeige MAPK1 Proteine) partner, DOC1R, a murine homologue of a potential human tumor suppressor gene; characterized DOC1R during mouse oocyte meiosis resumption
This gene encodes a protein that interacts with cyclin-dependent kinase 2 associated protein 1. Pseudogenes associated with this gene are located on chromosomes 7 and 9. Alternatively spliced transcript variants have been observed for this gene.
CDK2-associated protein 2
, DOC-1-related protein
, cyclin-dependent kinase 2-associated protein 2
, tumor suppressor deleted in oral cancer related 1
, tumor suppressor deleted in oral cancer-related 1
, DOC-1 related protein