STAT6
(Signal Transducer and Activator of Transcription 6, Interleukin-4 Induced (STAT6))
Spezies
Human
Quelle
Synthetic
Applikation
Blocking Peptide (BP), Western Blotting (WB), Immunohistochemistry (IHC)
Produktmerkmale
This is a synthetic peptide designed for use in combination with anti-STAT6 antibody (Catalog #: ARP38257_P050). It may block above mentioned antibody from binding to its target protein in western blot and/or immunohistochecmistry under proper experimental settings. There is no guarantee for its use in other applications.
Each Investigator should determine their own optimal working dilution for specific applications.
Beschränkungen
Nur für Forschungszwecke einsetzbar
Format
Lyophilized
Rekonstitution
Add 100 μL of sterile PBS. Final peptide concentration is 1 mg/mL in PBS.
Konzentration
1 mg/mL
Buffer
Final peptide concentration is 1 mg/mL in PBS.
Handhabung
Avoid repeated freeze-thaw cycles.
Lagerung
-20 °C
Informationen zur Lagerung
For longer periods of storage, store at -20°C. Avoid repeat freeze-thaw cycles.
Target
STAT6
(Signal Transducer and Activator of Transcription 6, Interleukin-4 Induced (STAT6))
Synonyme
D12S1644 Peptide, IL-4-STAT Peptide, STAT6B Peptide, STAT6C Peptide, signal transducer and activator of transcription 6 Peptide, signal transducer and activator of transcription 6-like Peptide, STAT6 Peptide, Stat6 Peptide, LOC100859543 Peptide
Hintergrund
STAT6 is a member of the STAT family of transcription factors. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. This protein plays a central role in exerting IL4 mediated biological responses. It is found to induce the expression of BCL2L1/BCL-X(L), which is responsible for the anti-apoptotic activity of IL4. Knockout studies in mice suggested the roles of this gene in differentiation of T helper 2 (Th2) cells, expression of cell surface markers, and class switch of immunoglobulins.The protein encoded by this gene is a member of the STAT family of transcription factors. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. This protein plays a central role in exerting IL4 mediated biological responses. It is found to induce the expression of BCL2L1/BCL-X(L), which is responsible for the anti-apoptotic activity of IL4. Knockout studies in mice suggested the roles of this gene in differentiation of T helper 2 (Th2) cells, expression of cell surface markers, and class switch of immunoglobulins.
Alias Symbols: D12S1644, IL-4-STAT, STAT6B, STAT6C
Protein Interaction Partner: IL4R,NMI,STAT6,CEBPB,CREBBP,EP300,ETS1,HIST2H3C,IL4R,IRF4,JAK1,NCOA1,NFKB1,NMI,PRKCZ,PTPN6,RELA,SND1,SRC,STAT2,STAT6,ANXA2,CREBBP,EP300,IRF4,NCOA1,NFKB1,SND1,TP53