SH2 Domain Protein 1A (SH2D1A) (C-Term) Peptid

Details zu Produkt Nr. ABIN983683, Anbieter: Anmelden zum Anzeigen
Proteinname
  • DSHP
  • EBVS
  • IMD5
  • LYP
  • MTCP1
  • SAP
  • SAP/SH2D1A
  • XLP
  • XLPD
  • Gm686
  • RGD1562408
  • SH2 domain containing 1A
  • SH2D1A
  • Sh2d1a
Protein Region
C-Term
Spezies
Human
Quelle
Synthetic
Applikation
Blocking Peptide (BP), Western Blotting (WB)
Optionen
Hersteller
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Hersteller Produkt- Nr.
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Geblockter Antikörper anti-SH2 Domain Containing 1A (SH2D1A) (C-Term) Antikörper (ABIN2788421)
Sequenz YFRKIKNLIS AFQKPDQGIV IPLQYPVEKK SSARSTQGTT GIREDPDVCL
Produktmerkmale This is a synthetic peptide designed for use in combination with anti-SH2D1A Antibody. It may block above mentioned antibody from binding to its target protein in western blot and/or immunohistochecmistry under proper experimental settings. There is no guarantee for its use in other applications.
Reinigung Purified
Proteinname SH2 Domain Protein 1A (SH2D1A)
Hintergrund SH2D1A is a protein that plays a major role in the bidirectional stimulation of T and B cells. It associates with the signaling lymphocyte-activation molecule, thereby acting as an inhibitor of this transmembrane protein by blocking the recruitment of the SH2-domain-containing signal-transduction molecule SHP-2 to its docking site. This protein can also bind to other related surface molecules that are expressed on activated T, B and NK cells, thereby modifying signal transduction pathways in these cells. Mutations in SH2D1A gene cause lymphoproliferative syndrome X-linked type 1 or Duncan disease, a rare immunodeficiency characterized by extreme susceptibility to infection with Epstein-Barr virus, with symptoms including severe mononucleosis and malignant lymphoma.

Alias Symbols: DSHP, EBVS, FLJ18687, FLJ92177, IMD5, LYP, MTCP1, SAP, XLP, XLPD, SAP/SH2D1A

Protein Interaction Partner: CD244,CD84,LY9,SLAMF1,SLAMF1,ARHGEF6,ARHGEF7,CD84,DOK1,FYB,FYN,GRB2,LCK,LY9,SLAMF1,SLAMF6,SLAMF7,CD244,CD84,DOK1,FYN,LY9,SLAMF1,SLAMF6

Protein Size: 128
Molekulargewicht 14 kDa
Gen-ID 4068
NCBI Accession NM_002351, NP_002342
UniProt O60880
Applikations-hinweise Each Investigator should determine their own optimal working dilution for specific applications.
Beschränkungen Nur für Forschungszwecke einsetzbar
Format Lyophilized
Rekonstitution Add 100 μL of sterile PBS. Final peptide concentration is 1 mg/mL in PBS.
Konzentration 1 mg/mL
Buffer Final peptide concentration is 1 mg/mL in PBS.
Handhabung Avoid repeated freeze-thaw cycles.
Lagerung -20 °C
Informationen zur Lagerung For longer periods of storage, store at -20°C. Avoid repeat freeze-thaw cycles.