This is a synthetic peptide designed for use in combination with anti-RBBP8 antibody (Catalog #: ARP50887_P050). It may block above mentioned antibody from binding to its target protein in western blot and/or immunohistochecmistry under proper experimental settings. There is no guarantee for its use in other applications.
RBBP8
Reaktivität: Human, Affe, Maus
Wirt: Synthetic
BP
Applikationshinweise
Each Investigator should determine their own optimal working dilution for specific applications.
Beschränkungen
Nur für Forschungszwecke einsetzbar
Format
Lyophilized
Rekonstitution
Add 100 μL of sterile PBS. Final peptide concentration is 1 mg/mL in PBS.
Konzentration
1 mg/mL
Buffer
Final peptide concentration is 1 mg/mL in PBS.
Handhabung
Avoid repeated freeze-thaw cycles.
Lagerung
-20 °C
Informationen zur Lagerung
For longer periods of storage, store at -20°C. Avoid repeat freeze-thaw cycles.
Target
Retinoblastoma Binding Protein 8 (RBBP8)
Synonyme
COM1 Peptide, CTIP Peptide, JWDS Peptide, RIM Peptide, SAE2 Peptide, SCKL2 Peptide, 9930104E21Rik Peptide, CtIP Peptide, RBBP-8 Peptide, RGD1308872 Peptide, RBBP8 Peptide, DKFZp469K0714 Peptide, RB binding protein 8, endonuclease Peptide, retinoblastoma binding protein 8, endonuclease Peptide, retinoblastoma binding protein 8 L homeolog Peptide, retinoblastoma binding protein 8 Peptide, RBBP8 Peptide, Rbbp8 Peptide, rbbp8.L Peptide, rbbp8 Peptide
Hintergrund
RBBP8 is a ubiquitously expressed nuclear protein. It is found among several proteins that bind directly to retinoblastoma protein, which regulates cell proliferation. This protein complexes with transcriptional co-repressor CTBP. It is also associated with BRCA1 and is thought to modulate the functions of BRCA1 in transcriptional regulation, DNA repair, and/or cell cycle checkpoint control. It is suggested that this gene may itself be a tumor suppressor acting in the same pathway as BRCA1. Three transcript variants encoding two different isoforms have been found for this gene. More transcript variants exist, but their full-length natures have not been determined.The protein encoded by this gene is a ubiquitously expressed nuclear protein. It is found among several proteins that bind directly to retinoblastoma protein, which regulates cell proliferation. This protein complexes with transcriptional co-repressor CTBP. It is also associated with BRCA1 and is thought to modulate the functions of BRCA1 in transcriptional regulation, DNA repair, and/or cell cycle checkpoint control. It is suggested that this gene may itself be a tumor suppressor acting in the same pathway as BRCA1. Three transcript variants encoding two different isoforms have been found for this gene. More transcript variants exist, but their full-length natures have not been determined.
Alias Symbols: CTIP, RIM, JWDS, SAE2, SCKL2
Protein Interaction Partner: BRCA1,LMO2,LMO4,ATM,BARD1,BRCA1,C17orf28,CTBP1,FXR2,IKZF1,IKZF3,LIMS1,LMO2,LMO4,PCNA,PIN1,RB1,RBBP8,RBL1,RBL2,SIAH1,SIAH2,TGIF2,WDYHV1,ATM,BARD1,BRCA1,C17orf28,CTBP1,FXR2,IKZF1,LIMS1,LMO4,Lmo2,PIN1,PRKDC,RB1,RBBP8,RBL1,RBL2,SIAH1,SIAH2,WDYHV1