This is a synthetic peptide designed for use in combination with anti-PTPN11 Antibody(ARP56494_P050),. It may block above mentioned antibody from binding to its target protein in western blot and/or immunohistochecmistry under proper experimental settings. There is no guarantee for its use in other applications.
PTPN11
Reaktivität: Human, Maus
Wirt: Synthetic
BP, BI
Applikationshinweise
Each Investigator should determine their own optimal working dilution for specific applications.
Beschränkungen
Nur für Forschungszwecke einsetzbar
Format
Lyophilized
Rekonstitution
Add 100 μL of sterile PBS. Final peptide concentration is 1 mg/mL in PBS.
Konzentration
1 mg/mL
Buffer
Final peptide concentration is 1 mg/mL in PBS.
Handhabung
Avoid repeated freeze-thaw cycles.
Lagerung
-20 °C
Informationen zur Lagerung
For longer periods of storage, store at -20°C. Avoid repeat freeze-thaw cycles.
Target
PTPN11
(Protein tyrosine Phosphatase, Non-Receptor Type 11 (PTPN11))
Synonyme
BPTP3 Peptide, CFC Peptide, NS1 Peptide, PTP-1D Peptide, PTP2C Peptide, SH-PTP2 Peptide, SH-PTP3 Peptide, SHP2 Peptide, 2700084A17Rik Peptide, AW536184 Peptide, PTP1D Peptide, SAP-2 Peptide, SHP-2 Peptide, Shp2 Peptide, Syp Peptide, SYP Peptide, bptp3 Peptide, cfc Peptide, ns1 Peptide, ptp-2 Peptide, ptp2c Peptide, ptpn11 Peptide, ptpn11-a Peptide, ptpn11-b Peptide, shp-2 Peptide, shp2 Peptide, fa14b09 Peptide, wu:fa14b09 Peptide, wu:fi24f03 Peptide, zgc:55388 Peptide, zgc:63553 Peptide, protein tyrosine phosphatase, non-receptor type 11 Peptide, protein tyrosine phosphatase, non-receptor type 11 S homeolog Peptide, protein tyrosine phosphatase, non-receptor type 11, a Peptide, protein tyrosine phosphatase, non-receptor type 11, b Peptide, PTPN11 Peptide, Ptpn11 Peptide, ptpn11.S Peptide, ptpn11a Peptide, ptpn11b Peptide
Substanzklasse
Viral Protein
Hintergrund
The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP contains two tandem Src homology-2 domains, which function as phospho-tyrosine binding domains and mediate the interaction of this PTP with its substrates. This PTP is widely expressed in most tissues and plays a regulatory role in various cell signaling events that are important for a diversity of cell functions, such as mitogenic activation, metabolic control, transcription regulation, and cell migration. Mutations in this gene are a cause of Noonan syndrome as well as acute myeloid leukemia.
Protein Interaction Partner: BCR,CAT,CAV1,FLT1,GAB1,GRB2,KIT,PDGFRB,PDGFRB,SLAMF1,cagA,ACTN4,ARHGAP1,AXL,BCR,BDKRB2,BTLA,C6orf25,CAT,CAV1,CBL,CCKBR,CD33,CDH5,CEACAM1,CHUK,CRKL,CSF2RB,CSF3R,CTLA4,CXCR4,DAB1,DDR1,EGFR,EPHA2,EPOR,ERBB2,FLT1,FLT4,FRS2,FRS3,FYN,GAB1,GAB2,GAB3,GHR,GRB2,GRI