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Perforin 1 (Pore Forming Protein) (PRF1) Peptid

PRF1 Reaktivität: Human Wirt: Synthetic BP, WB
Produktnummer ABIN982195
  • Target Alle Perforin 1 (PRF1) Produkte
    Perforin 1 (PRF1) (Perforin 1 (Pore Forming Protein) (PRF1))
    Spezies
    Human
    Quelle
    • 2
    Synthetic
    Applikation
    Blocking Peptide (BP), Western Blotting (WB)
    Produktmerkmale
    This is a synthetic peptide designed for use in combination with anti-PRF1 antibody (Catalog #: ARP42208_P050). It may block above mentioned antibody from binding to its target protein in western blot and/or immunohistochecmistry under proper experimental settings. There is no guarantee for its use in other applications.
    Aufreinigung
    Purified
  • Applikationshinweise
    Each Investigator should determine their own optimal working dilution for specific applications.
    Beschränkungen
    Nur für Forschungszwecke einsetzbar
  • Format
    Lyophilized
    Rekonstitution
    Add 100 μL of sterile PBS. Final peptide concentration is 1 mg/mL in PBS.
    Konzentration
    1 mg/mL
    Buffer
    Final peptide concentration is 1 mg/mL in PBS.
    Handhabung
    Avoid repeated freeze-thaw cycles.
    Lagerung
    -20 °C
    Informationen zur Lagerung
    For longer periods of storage, store at -20°C. Avoid repeat freeze-thaw cycles.
  • Target
    Perforin 1 (PRF1) (Perforin 1 (Pore Forming Protein) (PRF1))
    Synonyme
    FLH2 Peptide, HPLH2 Peptide, P1 Peptide, PFN1 Peptide, PFP Peptide, PRF1 Peptide, Pfn Peptide, Pfp Peptide, Prf-1 Peptide, Cyta Peptide, RATCYTA Peptide, LOC443187 Peptide, perforin Peptide, prf1 Peptide, cytolysin Peptide, perforin-1 Peptide, perforin-1-like Peptide, perforin 1 Peptide, perforin 1 (pore forming protein) Peptide, perforin Peptide, perforin 1 L homeolog Peptide, PRF1 Peptide, Prf1 Peptide, LOC443187 Peptide, prf1 Peptide, prf1.L Peptide
    Hintergrund
    PRF1 has structural and functional similarities to complement component 9 (C9). Like C9, this protein creates transmembrane tubules and is capable of lysing non-specifically a variety of target cells. This protein is one of the main cytolytic proteins of cytolytic granules, and it is known to be a key effector molecule for T-cell- and natural killer-cell-mediated cytolysis. Defects in the gene encoding PRF1 cause familial hemophagocytic lymphohistiocytosis type 2 (HPLH2), a rare and lethal autosomal recessive disorder of early childhood. The protein encoded by this gene has structural and functional similarities to complement component 9 (C9). Like C9, this protein creates transmembrane tubules and is capable of lysing non-specifically a variety of target cells. This protein is one of the main cytolytic proteins of cytolytic granules, and it is known to be a key effector molecule for T-cell- and natural killer-cell-mediated cytolysis. Defects in this gene cause familial hemophagocytic lymphohistiocytosis type 2 (HPLH2), a rare and lethal autosomal recessive disorder of early childhood. Alternative splicing results in multiple transcript variants encoding the same protein.

    Alias Symbols: FLH2, HPLH2, MGC65093, P1, PFP, PFN1

    Protein Interaction Partner: CALR,DDX24,GZMB,CALR

    Protein Size: 555
    Molekulargewicht
    59 kDa
    Gen-ID
    5551
    NCBI Accession
    NM_005041, NP_005032
    UniProt
    P14222
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