Pleckstrin Homology Domain Containing, Family O Member 1 (PLEKHO1) (N-Term) Peptid

Details zu Produkt Nr. ABIN981861, Anbieter: Anmelden zum Anzeigen
Proteinname
  • CKIP-1
  • OC120
  • 2810052M02Rik
  • Ckip1
  • JZA-20
  • Jza2
  • RGD1311487
  • pleckstrin homology domain containing O1
  • pleckstrin homology domain containing, family O member 1
  • PLEKHO1
  • Plekho1
Protein Region
N-Term
Spezies
Human
2
Quelle
Synthetic
Applikation
Blocking Peptide (BP), Western Blotting (WB)
Optionen
Hersteller
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Geblockter Antikörper anti-Pleckstrin Homology Domain Containing, Family O Member 1 (PLEKHO1) (N-Term) Antikörper (ABIN2783148)
Sequenz MMKKNNSAKR GPQDGNQQPA PPEKVGWVRK FCGKGIFREI WKNRYVVLKG
Produktmerkmale This is a synthetic peptide designed for use in combination with anti-PLEKHO1 Antibody(ARP47817_P050),. It may block above mentioned antibody from binding to its target protein in western blot and/or immunohistochecmistry under proper experimental settings. There is no guarantee for its use in other applications.
Reinigung Purified
Hintergrund PLEKHO1 plays a role in the regulation of the actin cytoskeleton through its interactions with actin capping protein (CP).PLEKHO1 may function to target CK2 to the plasma membrane thereby serving as an adapter to facilitate the phosphorylation of CP by protein kinase 2 (CK2). PLEKHO1 appears to target ATM to the plasma membrane. PLEKHO1 appears to also inhibit tumor cell growth by inhibiting AKT-mediated cell-survival. PLEKHO1 is also implicated in PI3K-regulated muscle differentiation, the regulation of AP-1 activity (plasma membrane bound AP-1 regulator that translocates to the nucleus) and the promotion of apoptosis induced by tumor necrosis factor TNF. When bound to PKB, it inhibits it probably by decreasing PKB level of phosphorylation.

Alias Symbols: CKIP-1, OC120, RP11-458I7.3

Protein Interaction Partner: CSNK2A1,SMURF1,USP7,CASP3,JUN,JUND,PLEKHO1,CSNK2A1,SMAD5,SMURF1

Protein Size: 409
Molekulargewicht 46 kDa
Gen-ID 51177
NCBI Accession NM_016274, NP_057358
UniProt Q53GL0
Applikations-hinweise Each Investigator should determine their own optimal working dilution for specific applications.
Beschränkungen Nur für Forschungszwecke einsetzbar
Format Lyophilized
Rekonstitution Add 100 μL of sterile PBS. Final peptide concentration is 1 mg/mL in PBS.
Konzentration 1 mg/mL
Buffer Final peptide concentration is 1 mg/mL in PBS.
Handhabung Avoid repeated freeze-thaw cycles.
Lagerung -20 °C
Informationen zur Lagerung For longer periods of storage, store at -20°C. Avoid repeat freeze-thaw cycles.