Plasminogen Activator, Urokinase (PLAU) (C-Term) Peptid
PLAU
Reaktivität: Human
Wirt: Synthetic
BP, WB
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- Target Alle PLAU Produkte
- PLAU (Plasminogen Activator, Urokinase (PLAU))
- Protein Region
- C-Term
- Spezies
- Human
-
Quelle
- Synthetic
- Applikation
- Blocking Peptide (BP), Western Blotting (WB)
- Sequenz
- CSLQGRMTLT GIVSWGRGCA LKDKPGVYTR VSHFLPWIRS HTKEENGLAL
- Produktmerkmale
- This is a synthetic peptide designed for use in combination with anti-PLAU Antibody. It may block above mentioned antibody from binding to its target protein in western blot and/or immunohistochecmistry under proper experimental settings. There is no guarantee for its use in other applications.
- Aufreinigung
- Purified
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-
- Applikationshinweise
- Each Investigator should determine their own optimal working dilution for specific applications.
- Beschränkungen
- Nur für Forschungszwecke einsetzbar
-
- Format
- Lyophilized
- Rekonstitution
- Add 100 μL of sterile PBS. Final peptide concentration is 1 mg/mL in PBS.
- Konzentration
- 1 mg/mL
- Buffer
- Final peptide concentration is 1 mg/mL in PBS.
- Handhabung
- Avoid repeated freeze-thaw cycles.
- Lagerung
- -20 °C
- Informationen zur Lagerung
- For longer periods of storage, store at -20°C. Avoid repeat freeze-thaw cycles.
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- Target
- PLAU (Plasminogen Activator, Urokinase (PLAU))
- Synonyme
- PLAU Peptide, u-PA Peptide, ATF Peptide, BDPLT5 Peptide, QPD Peptide, UPA Peptide, URK Peptide, uPA Peptide, UPAM Peptide, plasminogen activator, urokinase Peptide, urokinase-type plasminogen activator Peptide, PLAU Peptide, CpipJ_CPIJ002131 Peptide, CpipJ_CPIJ006543 Peptide, CpipJ_CPIJ013396 Peptide, CpipJ_CPIJ013623 Peptide, Plau Peptide
- Hintergrund
-
This gene encodes a serine protease involved in degradation of the extracellular matrix and possibly tumor cell migration and proliferation. A specific polymorphism in this gene may be associated with late-onset Alzheimer's disease and also with decreased affinity for fibrin-binding. This protein converts plasminogen to plasmin by specific cleavage of an Arg-Val bond in plasminogen. Plasmin in turn cleaves this protein at a Lys-Ile bond to form a two-chain derivative in which a single disulfide bond connects the amino-terminal A-chain to the catalytically active, carboxy-terminal B-chain. This two-chain derivative is also called HMW-uPA (high molecular weight uPA). HMW-uPA can be further processed into LMW-uPA (low molecular weight uPA) by cleavage of chain A into a short chain A (A1) and an amino-terminal fragment. LMW-uPA is proteolytically active but does not bind to the uPA receptor.
Alias Symbols: ATF, UPA, URK, u-PA, QPD, BDPLT5
Protein Interaction Partner: CTSB,CTSL1,F2,HGF,IGF2R,LRP2,NID1,PLAT,PLAUR,PLG,SERPINA5,SERPINB2,SERPINB6,SERPINE1,SERPINF2,ST14,HRAS,LRP2,MAP2K1,PLAT,PLAUR,SERPINA5,SERPINB2,SERPINE1,SERPINE2
Protein Size: 431 - Molekulargewicht
- 28 kDa
- Gen-ID
- 5328
- NCBI Accession
- NM_002658, NP_002649
- UniProt
- P00749
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