Plasminogen Activator, Urokinase (PLAU) (C-Term) Peptid

Details zu Produkt Nr. ABIN981838, Anbieter: Anmelden zum Anzeigen
Proteinname
  • PLAU
  • u-PA
  • ATF
  • BDPLT5
  • QPD
  • UPA
  • URK
  • uPA
  • UPAM
  • plasminogen activator, urokinase
  • urokinase-type plasminogen activator
  • PLAU
  • CpipJ_CPIJ002131
  • CpipJ_CPIJ006543
  • CpipJ_CPIJ013396
  • CpipJ_CPIJ013623
  • Plau
Protein Region
C-Term
Spezies
Human
2
Quelle
Synthetic
Applikation
Blocking Peptide (BP), Western Blotting (WB)
Optionen
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Geblockter Antikörper anti-PLAU Antikörper (Plasminogen Activator, Urokinase) (C-Term) (ABIN2789605)
Sequenz CSLQGRMTLT GIVSWGRGCA LKDKPGVYTR VSHFLPWIRS HTKEENGLAL
Produktmerkmale This is a synthetic peptide designed for use in combination with anti-PLAU Antibody. It may block above mentioned antibody from binding to its target protein in western blot and/or immunohistochecmistry under proper experimental settings. There is no guarantee for its use in other applications.
Reinigung Purified
Hintergrund This gene encodes a serine protease involved in degradation of the extracellular matrix and possibly tumor cell migration and proliferation. A specific polymorphism in this gene may be associated with late-onset Alzheimer's disease and also with decreased affinity for fibrin-binding. This protein converts plasminogen to plasmin by specific cleavage of an Arg-Val bond in plasminogen. Plasmin in turn cleaves this protein at a Lys-Ile bond to form a two-chain derivative in which a single disulfide bond connects the amino-terminal A-chain to the catalytically active, carboxy-terminal B-chain. This two-chain derivative is also called HMW-uPA (high molecular weight uPA). HMW-uPA can be further processed into LMW-uPA (low molecular weight uPA) by cleavage of chain A into a short chain A (A1) and an amino-terminal fragment. LMW-uPA is proteolytically active but does not bind to the uPA receptor.

Alias Symbols: ATF, UPA, URK, u-PA, QPD, BDPLT5

Protein Interaction Partner: CTSB,CTSL1,F2,HGF,IGF2R,LRP2,NID1,PLAT,PLAUR,PLG,SERPINA5,SERPINB2,SERPINB6,SERPINE1,SERPINF2,ST14,HRAS,LRP2,MAP2K1,PLAT,PLAUR,SERPINA5,SERPINB2,SERPINE1,SERPINE2

Protein Size: 431
Molekulargewicht 28 kDa
Gen-ID 5328
NCBI Accession NM_002658, NP_002649
UniProt P00749
Applikationshinweise Each Investigator should determine their own optimal working dilution for specific applications.
Beschränkungen Nur für Forschungszwecke einsetzbar
Format Lyophilized
Rekonstitution Add 100 μL of sterile PBS. Final peptide concentration is 1 mg/mL in PBS.
Konzentration 1 mg/mL
Buffer Final peptide concentration is 1 mg/mL in PBS.
Handhabung Avoid repeated freeze-thaw cycles.
Lagerung -20 °C
Informationen zur Lagerung For longer periods of storage, store at -20°C. Avoid repeat freeze-thaw cycles.