This gene encodes tissue-type plasminogen activator, a secreted serine protease which converts the proenzyme plasminogen to plasmin, a fibrinolytic enzyme. Tissue-type plasminogen activator is synthesized as a single chain which is cleaved by plasmin to a two chain disulfide linked protein. This enzyme plays a role in cell migration and tissue remodeling. Increased enzymatic activity causes hyperfibrinolysis, which manifests as excessive bleeding, decreased activity leads to hypofibrinolysis which can result in thrombosis or embolism. Alternative splicing of this gene results in multiple transcript variants encoding different isoforms.
Alias Symbols: DKFZp686I03148, T-PA, TPA
Protein Interaction Partner: ANXA2,CALR,CKAP4,CLEC3B,F10,FGA,GRIN1,HMGB1,KRT8,LAMA1,LAMA3,LRP1,LRP1B,MAPK1,MAPK3,PLAT,PLAU,PLG,SERPINA5,SERPINE1,SERPING1,SERPINI1,SPARC,ANXA2,CALR,CLEC3B,F10,F2,FGA,FN1,HMGB1,KRT8,LAMA1,LAMA5,LRP1,PLAU,SERPINA5,SERPINE1,SERPINI1
Protein Size: 516