Paired Immunoglobin-Like Type 2 Receptor alpha (PILRA) Peptid

Details zu Produkt Nr. ABIN981765, Anbieter: Anmelden zum Anzeigen
Proteinname
  • PILRA
  • FDF03
  • AV021745
  • RGD1562847
  • paired immunoglobin like type 2 receptor alpha
  • paired immunoglobulin-like type 2 receptor alpha
  • paired immunoglobin-like type 2 receptor alpha
  • PILRA
  • LOC489841
  • Pilra
Spezies
Human
1
Quelle
Synthetic
Applikation
Blocking Peptide (BP), Western Blotting (WB)
Optionen
Hersteller
Anmelden zum Anzeigen
Hersteller Produkt- Nr.
Anmelden zum Anzeigen
Geblockter Antikörper anti-PILRA Antikörper (Paired Immunoglobin-Like Type 2 Receptor alpha) (N-Term) (ABIN2782793)
Produktmerkmale This is a synthetic peptide designed for use in combination with anti-PILRA antibody (Catalog #: ARP46947_P050). It may block above mentioned antibody from binding to its target protein in western blot and/or immunohistochecmistry under proper experimental settings. There is no guarantee for its use in other applications.
Reinigung Purified
Proteinname
Hintergrund Cell signaling pathways rely on a dynamic interaction between activating and inhibiting processes. SHP-1-mediated dephosphorylation of protein tyrosine residues is central to the regulation of several cell signaling pathways. Two types of inhibitory receptor superfamily members are immunoreceptor tyrosine-based inhibitory motif (ITIM)-bearing receptors and their non-ITIM-bearing, activating counterparts. Control of cell signaling via SHP-1 is thought to occur through a balance between PILRalpha-mediated inhibition and PILRbeta-mediated activation. This particular gene encodes the ITIM-bearing member of the receptor pair, which functions in the inhibitory role.Cell signaling pathways rely on a dynamic interaction between activating and inhibiting processes. SHP-1-mediated dephosphorylation of protein tyrosine residues is central to the regulation of several cell signaling pathways. Two types of inhibitory receptor superfamily members are immunoreceptor tyrosine-based inhibitory motif (ITIM)-bearing receptors and their non-ITIM-bearing, activating counterparts. Control of cell signaling via SHP-1 is thought to occur through a balance between PILRalpha-mediated inhibition and PILRbeta-mediated activation. These paired immunoglobulin-like receptor genes are located in a tandem head-to-tail orientation on chromosome 7. This particular gene encodes the ITIM-bearing member of the receptor pair, which functions in the inhibitory role. Alternative splicing has been observed at this locus and three variants, each encoding a distinct isoform, are described.

Alias Symbols: FDF03

Protein Interaction Partner: FCAR,PTPN11,PTPN6,PTPN11,PTPN6

Protein Size: 175
Molekulargewicht 18 kDa
Gen-ID 29992
NCBI Accession NM_178273, NP_840057
Applikations-hinweise Each Investigator should determine their own optimal working dilution for specific applications.
Beschränkungen Nur für Forschungszwecke einsetzbar
Format Lyophilized
Rekonstitution Add 100 μL of sterile PBS. Final peptide concentration is 1 mg/mL in PBS.
Konzentration 1 mg/mL
Buffer Final peptide concentration is 1 mg/mL in PBS.
Handhabung Avoid repeated freeze-thaw cycles.
Lagerung -20 °C
Informationen zur Lagerung For longer periods of storage, store at -20°C. Avoid repeat freeze-thaw cycles.