This is a synthetic peptide designed for use in combination with anti-MED14 Antibody(ARP58139_P050),. It may block above mentioned antibody from binding to its target protein in western blot and/or immunohistochecmistry under proper experimental settings. There is no guarantee for its use in other applications.
The activation of gene transcription is a multistep process that is triggered by factors that recognize transcriptional enhancer sites in DNA. These factors work with co-activators to direct transcriptional initiation by the RNA polymerase II apparatus. The protein encoded by this gene is a subunit of the CRSP (cofactor required for SP1 activation) complex, which, along with TFIID, is required for efficient activation by SP1. This protein is also a component of other multisubunit complexes e.g. thyroid hormone receptor-(TR-) associated proteins which interact with TR and facilitate TR function on DNA templates in conjunction with initiation factors and cofactors. This protein contains a bipartite nuclear localization signal. This gene is known to escape chromosome X-inactivation.
Protein Interaction Partner: ACTN1,ACTN2,AR,HNF4A,MED1,MED29,MED9,NR3C1,STAT2,UACA,BRD4,CDK8,ESR1,ESR2,GATA1,HNF4A,MED1,MED10,MED19,MED21,MED26,MED28,MED29,MED6,MED9,MYC,NR3C1,PPARGC1A,STAT2,VDR