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G protein beta subunit-like (GBL) (Middle Region) Peptid

GBL Reaktivität: Human Wirt: Synthetic BP, WB
Produktnummer ABIN977310
  • Target Alle GBL Produkte
    GBL (G protein beta subunit-like (GBL))
    Protein Region
    Middle Region
    Spezies
    Human
    Quelle
    • 2
    Synthetic
    Applikation
    Blocking Peptide (BP), Western Blotting (WB)
    Sequenz
    CAFSGDSQYI VTASSDNLAR LWCVETGEIK REYGGHQKAV VCLAFNDSVL
    Produktmerkmale
    This is a synthetic peptide designed for use in combination with anti-GBL Antibody(ARP57630_P050),. It may block above mentioned antibody from binding to its target protein in western blot and/or immunohistochecmistry under proper experimental settings. There is no guarantee for its use in other applications.
    Aufreinigung
    Purified
  • Applikationshinweise
    Each Investigator should determine their own optimal working dilution for specific applications.
    Beschränkungen
    Nur für Forschungszwecke einsetzbar
  • Format
    Lyophilized
    Rekonstitution
    Add 100 μL of sterile PBS. Final peptide concentration is 1 mg/mL in PBS.
    Konzentration
    1 mg/mL
    Buffer
    Final peptide concentration is 1 mg/mL in PBS.
    Handhabung
    Avoid repeated freeze-thaw cycles.
    Lagerung
    -20 °C
    Informationen zur Lagerung
    For longer periods of storage, store at -20°C. Avoid repeat freeze-thaw cycles.
  • Target
    GBL (G protein beta subunit-like (GBL))
    Synonyme
    gbl Peptide, lts8 Peptide, GBL Peptide, GbetaL Peptide, LST8 Peptide, POP3 Peptide, WAT1 Peptide, 0610033N12Rik Peptide, AA409454 Peptide, AI505104 Peptide, AI851821 Peptide, Gbl Peptide, fi37e04 Peptide, wu:fi37e04 Peptide, zgc:55455 Peptide, zgc:85668 Peptide, MTOR associated protein, LST8 homolog L homeolog Peptide, MTOR associated protein, LST8 homolog Peptide, MTOR associated protein, LST8 homolog (S. cerevisiae) Peptide, mlst8.L Peptide, MLST8 Peptide, Mlst8 Peptide, mlst8 Peptide
    Hintergrund
    GBL is the subunit of both mTORC1 and mTORC2, which regulate cell growth and survival in response to nutrient and hormonal signals. mTORC1 is activated in response to growth factors or amino-acids. Activated mTORC1 up-regulates protein synthesis by phosphorylating key regulators of mRNA translation and ribosome synthesis. mTORC2 seems to function upstream of Rho GTPases to regulate the actin cytoskeleton, probably by activating one or more Rho-type guanine nucleotide exchange factors. mTORC2 promotes the serum-induced formation of stress-fibers or F-actin. mTORC2 plays a critical role in AKT1 'Ser-473' phosphorylation, which may facilitate the phosphorylation of the activation loop of AKT1 on 'Thr-308' by PDK1 which is a prerequisite for full activation. mTORC2 regulates the phosphorylation of SGK1 at 'Ser-422'. mTORC2 also modulates the phosphorylation of PRKCA on 'Ser-657'.

    Alias Symbols: MGC111011, GBL, LST8, POP3, WAT1, GbetaL

    Protein Interaction Partner: MTOR,RPTOR,RHEB,CCT2,KRT85,MTOR,RPTOR

    Protein Size: 326
    Molekulargewicht
    36 kDa
    Gen-ID
    64223
    NCBI Accession
    NM_022372, NP_071767
    UniProt
    Q9BVC4
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