This is a synthetic peptide designed for use in combination with anti-COL4A3 Antibody. It may block above mentioned antibody from binding to its target protein in western blot and/or immunohistochecmistry under proper experimental settings. There is no guarantee for its use in other applications.
Each Investigator should determine their own optimal working dilution for specific applications.
Beschränkungen
Nur für Forschungszwecke einsetzbar
Format
Lyophilized
Rekonstitution
Add 100 μL of sterile PBS. Final peptide concentration is 1 mg/mL in PBS.
Konzentration
1 mg/mL
Buffer
Final peptide concentration is 1 mg/mL in PBS.
Handhabung
Avoid repeated freeze-thaw cycles.
Lagerung
-20 °C
Informationen zur Lagerung
For longer periods of storage, store at -20°C. Avoid repeat freeze-thaw cycles.
Target
COL4a3 (COL4A3)
(Collagen, Type IV, alpha 3 (COL4A3))
Synonyme
zTumstatin Peptide, [a]3(IV) Peptide, alpha3(IV) Peptide, collagen type IV alpha 3 chain Peptide, collagen, type IV, alpha 3 Peptide, COL4A3 Peptide, col4a3 Peptide, Col4a3 Peptide
Hintergrund
This gene encodes the pro-alpha1 chains of type I collagen whose triple helix comprises two alpha1 chains and one alpha2 chain. Type I is a fibril-forming collagen found in most connective tissues and is abundant in bone, cornea, dermis and tendon. Mutations in this gene are associated with osteogenesis imperfecta types I-IV, Ehlers-Danlos syndrome type VIIA, Ehlers-Danlos syndrome Classical type, Caffey Disease and idiopathic osteoporosis. Reciprocal translocations between chromosomes 17 and 22, where this gene and the gene for platelet-derived growth factor beta are located, are associated with a particular type of skin tumor called dermatofibrosarcoma protuberans, resulting from unregulated expression of the growth factor. Two transcripts, resulting from the use of alternate polyadenylation signals, have been identified for this gene.
Alias Symbols: -
Protein Interaction Partner: CAPN1,BGN,BMP1,CAPN1,CD36,CD44,CD93,COL7A1,DCN,DDR2,FGF7,FN1,HTRA1,IGFBP3,ITGA2,ITGA5,MATN2,MMP2,MMP9,NID1,P4HB,PAK1,PDGFB,PRELP,SPARC,TGFBI,THBS1,TMPRSS6,TXN,VWF,COL7A1,IGFBP3,ITGA2,ITGB1,MAG,MATN2,MMP2,NID1,NID2,Nid1,PKD1,PRELP,SPARC,THBS1,TXN,VWF