Cadherin 1, Type 1, E-Cadherin (Epithelial) (CDH1) (Middle Region) Peptid
CDH1
Reaktivität: Human
Wirt: Synthetic
BP, WB, IHC, IF
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- Target Alle E-cadherin (CDH1) Produkte
- E-cadherin (CDH1) (Cadherin 1, Type 1, E-Cadherin (Epithelial) (CDH1))
- Protein Region
- Middle Region
- Spezies
- Human
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Quelle
- Synthetic
- Applikation
- Blocking Peptide (BP), Western Blotting (WB), Immunohistochemistry (IHC), Immunofluorescence (IF)
- Produktmerkmale
- This is a synthetic peptide designed for use in combination with anti-CDH1 antibody (Catalog #: ARP51289_P050). It may block above mentioned antibody from binding to its target protein in western blot and/or immunohistochecmistry under proper experimental settings. There is no guarantee for its use in other applications.
- Aufreinigung
- Purified
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- Applikationshinweise
- Each Investigator should determine their own optimal working dilution for specific applications.
- Beschränkungen
- Nur für Forschungszwecke einsetzbar
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- Format
- Lyophilized
- Rekonstitution
- Add 100 μL of sterile PBS. Final peptide concentration is 1 mg/mL in PBS.
- Konzentration
- 1 mg/mL
- Buffer
- Final peptide concentration is 1 mg/mL in PBS.
- Handhabung
- Avoid repeated freeze-thaw cycles.
- Lagerung
- -20 °C
- Informationen zur Lagerung
- For longer periods of storage, store at -20°C. Avoid repeat freeze-thaw cycles.
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- Target
- E-cadherin (CDH1) (Cadherin 1, Type 1, E-Cadherin (Epithelial) (CDH1))
- Synonyme
- Arc-1 Peptide, CD324 Peptide, CDHE Peptide, ECAD Peptide, LCAM Peptide, UVO Peptide, E-cadherin Peptide, cdh1 Peptide, si:dz180o5.2 Peptide, uvo Peptide, lcam Peptide, E-Cad Peptide, XBcad Peptide, l-cam Peptide, xcdh1 Peptide, cdhc-A Peptide, xb-cad Peptide, XTCAD-1 Peptide, c-cadherin Peptide, cadherin-1 Peptide, uvomorulin Peptide, XB-cadherin Peptide, arc-1 Peptide, cd324 Peptide, cdhe Peptide, ecad Peptide, AA960649 Peptide, E-cad Peptide, Ecad Peptide, L-CAM Peptide, Um Peptide, cadherin 1 Peptide, si:busm1-180o5.2 Peptide, cadherin 1, type 1, E-cadherin (epithelial) Peptide, cadherin 1, type 1 S homeolog Peptide, CDH1 Peptide, si:busm1-180o5.2 Peptide, cdh1 Peptide, Cdh1 Peptide, cdh1.S Peptide
- Hintergrund
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Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells, cadherins may thus contribute to the sorting of heterogeneous cell types. CDH1 is involved in mechanisms regulating cell-cell adhesions, mobility and proliferation of epithelial cells. Has a potent invasive suppressor role. It is a ligand for integrin alpha-E/beta-7.This gene is a classical cadherin from the cadherin superfamily. The encoded protein is a calcium dependent cell-cell adhesion glycoprotein comprised of five extracellular cadherin repeats, a transmembrane region and a highly conserved cytoplasmic tail. Mutations in this gene are correlated with gastric, breast, colorectal, thyroid and ovarian cancer. Loss of function is thought to contribute to progression in cancer by increasing proliferation, invasion, and/or metastasis. The ectodomain of this protein mediates bacterial adhesion to mammalian cells and the cytoplasmic domain is required for internalization. Identified transcript variants arise from mutation at consensus splice sites. Sequence Note: This RefSeq record was created from transcript and genomic sequence data because no single transcript was available for the full length of the gene. The extent of this transcript is supported by transcript alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Entrez Gene record to access additional publications.
Alias Symbols: Arc-1, CD324, CDHE, ECAD, LCAM, UVO
Protein Interaction Partner: ZEB1,CAV1,CTNNB1,CTNNB1,CTNNB1,CTNND1,EGFR,ACTR3,ANAPC7,ARHGAP32,ARVCF,CA9,CASP3,CASP8,CBLL1,CDH1,CSE1L,CSNK2A1,CTNNA1,CTNNB1,CTNND1,CTNND2,EGFR,ERBB2IP,EZR,GNA12,GNA13,GSK3B,HDAC1,HDAC2,IQGAP1,IRS1,ITGAE,ITGB7,JUP,NDRG1,NEDD9,PKD1,PPP1CA,PSEN1,PTPN14,PTPRF,PTPRM,RAB8B,RRM2,VCL,ACTG1,ACTN1,AJAP1,ANAPC1,ANAPC11,ANAPC4,ANAPC7,APC2,ARPC2,BOC,CA9,CBLL1,CDC16,CDC23,CDC26,CDC27,CDH1,CDH3,CDON,CSE1L,CTNNA1,CTNNB1,CTNND1,EGFR,EZR,FER,FOXM1,FYN,GNA12,GNA13,HDAC1,HDAC2,IQGAP1,ITGAE,JUP,MAD2L2,MAGI1,MDM2,MET,MYO7A,NEDD9,PKP4,PSEN1,RAB8B,SRC,UBC,VCL,VEZT,YES1
Protein Size: 882 - Molekulargewicht
- 80 kDa
- Gen-ID
- 999
- NCBI Accession
- NM_004360, NP_004351
- UniProt
- P12830
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