Blocking Peptide (BP), Western Blotting (WB), Immunohistochemistry (IHC)
Produktmerkmale
This is a synthetic peptide designed for use in combination with anti-BACE1 antibody (Catalog #: ARP46851_P050). It may block above mentioned antibody from binding to its target protein in western blot and/or immunohistochecmistry under proper experimental settings. There is no guarantee for its use in other applications.
Cerebral deposition of amyloid beta peptide is an early and critical feature of Alzheimer's disease. Amyloid beta peptide is generated by proteolytic cleavage of amyloid precursor protein (APP) by two proteases, one of which is the protein. BACE1, a member of the peptidase A1 protein family, is a type I integral membrane glycoprotein and aspartic protease that is found mainly in the Golgi.Cerebral deposition of amyloid beta peptide is an early and critical feature of Alzheimer's disease. Amyloid beta peptide is generated by proteolytic cleavage of amyloid precursor protein (APP) by two proteases, one of which is the protein encoded by this gene. The encoded protein, a member of the peptidase A1 protein family, is a type I integral membrane glycoprotein and aspartic protease that is found mainly in the Golgi. Four transcript variants encoding different isoforms have been described for this gene.
Alias Symbols: ASP2, BACE, FLJ90568, HSPC104, KIAA1149
Protein Interaction Partner: ATP1B1,CMPK1,ITM2C,KHSRP,NCSTN,PDIA3,PSAP,RANBP9,APP,ATP1B1,BRI3,CMPK1,CSNK1D,FURIN,GGA2,ITM2C,KHSRP,LRP1,MMP2,NCSTN,PDIA3,PLSCR1,PSAP,PSEN1,RANBP9,SELPLG,NCSTN