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Adducin 2 (Beta) (ADD2) (Middle Region) Peptid

ADD2 Reaktivität: Human Wirt: Synthetic BP, WB, ICC
Produktnummer ABIN972930
  • Target Alle ADD2 Produkte
    ADD2 (Adducin 2 (Beta) (ADD2))
    Protein Region
    Middle Region
    Spezies
    Human
    Quelle
    • 2
    Synthetic
    Applikation
    Blocking Peptide (BP), Western Blotting (WB), Immunocytochemistry (ICC)
    Produktmerkmale
    This is a synthetic peptide designed for use in combination with anti-ADD2 antibody (Catalog #: ARP52378_P050). It may block above mentioned antibody from binding to its target protein in western blot and/or immunohistochecmistry under proper experimental settings. There is no guarantee for its use in other applications.
    Aufreinigung
    Purified
  • Applikationshinweise
    Each Investigator should determine their own optimal working dilution for specific applications.
    Beschränkungen
    Nur für Forschungszwecke einsetzbar
  • Format
    Lyophilized
    Rekonstitution
    Add 100 μL of sterile PBS. Final peptide concentration is 1 mg/mL in PBS.
    Konzentration
    1 mg/mL
    Buffer
    Final peptide concentration is 1 mg/mL in PBS.
    Handhabung
    Avoid repeated freeze-thaw cycles.
    Lagerung
    -20 °C
    Informationen zur Lagerung
    For longer periods of storage, store at -20°C. Avoid repeat freeze-thaw cycles.
  • Target
    ADD2 (Adducin 2 (Beta) (ADD2))
    Synonyme
    si:dkey-202n14.5 Peptide, ADDB Peptide, 2900072M03Rik Peptide, add97 Peptide, beta-ADD Peptide, adducin 2 Peptide, adducin 2 (beta) Peptide, ADD2 Peptide, add2 Peptide, Add2 Peptide
    Hintergrund
    Adducins are heteromeric proteins composed of different subunits referred to as adducin alpha, beta and gamma. The three subunits are encoded by distinct genes and belong to a family of membrane skeletal proteins involved in the assembly of spectrin-actin network in erythrocytes and at sites of cell-cell contact in epithelial tissues. Adducin, originally purified from human erythrocytes, was found to be a heterodimer of adducins alpha and beta. Polymorphisms resulting in amino acid substitutions in these two subunits have been associated with the regulation of blood pressure in an animal model of hypertension. Structurally, each subunit is comprised of two distinct domains. The amino-terminal region is protease resistant and globular in shape, while the carboxy-terminal region is protease sensitive. The latter contains multiple phosphorylation sites for protein kinase C, the binding site for calmodulin, and is required for association with spectrin and actin. Adducins are heteromeric proteins composed of different subunits referred to as adducin alpha, beta and gamma. The three subunits are encoded by distinct genes and belong to a family of membrane skeletal proteins involved in the assembly of spectrin-actin network in erythrocytes and at sites of cell-cell contact in epithelial tissues. While adducins alpha and gamma are ubiquitously expressed, the expression of adducin beta is restricted to brain and hematopoietic tissues. Adducin, originally purified from human erythrocytes, was found to be a heterodimer of adducins alpha and beta. Polymorphisms resulting in amino acid substitutions in these two subunits have been associated with the regulation of blood pressure in an animal model of hypertension. Heterodimers consisting of alpha and gamma subunits have also been described. Structurally, each subunit is comprised of two distinct domains. The amino-terminal region is protease resistant and globular in shape, while the carboxy-terminal region is protease sensitive. The latter contains multiple phosphorylation sites for protein kinase C, the binding site for calmodulin, and is required for association with spectrin and actin. Various adducin beta mRNAs, alternatively spliced at 3'end and/or internally spliced and encoding different isoforms, have been described. The functions of all the different isoforms are not known.

    Alias Symbols: ADDB

    Protein Interaction Partner: ADD1,ADD2,CALM1,FYN,PRKACA,PRKCD,PTPRZ1,RPH3A,FYN,RPH3A

    Protein Size: 726
    Molekulargewicht
    80 kDa
    Gen-ID
    119
    NCBI Accession
    NM_001617, NP_001608
    UniProt
    P35612
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