A synthetic peptide for use as a blocking control in assays to test for specificity of TRIB2 antibody, Alternative Names: TRIB2 control peptide, TRIB2 antibody Blocking Peptide, Anti-TRIB2 Blocking Peptide, Tribbles Homolog 2 Blocking Peptide, GS3955 Blocking Peptide, TRB2 Blocking Peptide, TRIB2, TRIB-2, TRIB 2, TRIB-2 Blocking Peptide, TRIB 2 Blocking Peptide
TRIB2 is one of three members of the Tribbles family. The Tribbles members share a Trb domain, which is homologous to protein serine-threonine kinases, but lacks the active site lysine and probably lacks a catalytic function. The Tribbles proteins interact and modulate the activity of signal transduction pathways in a number of physiological and pathological processes. This Tribbles member induces apoptosis of cells mainly of the hematopoietic origin. It has been identified as a protein up-regulated by inflammatory stimuli in myeloid (THP-1) cells, and also as an oncogene that inactivates the transcription factor C/EBPalpha (CCAAT/enhancer-binding protein alpha) and causes acute myelogenous leukemia.