A synthetic peptide for use as a blocking control in assays to test for specificity of SEC63 antibody, Alternative Names: SEC63 control peptide, SEC63 antibody Blocking Peptide, Anti-SEC63 Blocking Peptide, Sec63 Homolog Blocking Peptide, ERdj2 Blocking Peptide, PRO2507 Blocking Peptide, SEC63L Blocking Peptide, SEC63, SEC-63, SEC 63, SEC-63 Blocking Peptide, SEC 63 Blocking Peptide
The Sec61 complex is the central component of the protein translocation apparatus of the endoplasmic reticulum (ER) membrane. SEC63 and SEC62 protein are found to be associated with ribosome-free SEC61 complex. It is speculated that Sec61-Sec62-Sec63 may perform post-translational protein translocation into the ER. The Sec61-Sec62-Sec63 complex might also perform the backward transport of ER proteins that are subject to the ubiquitin-proteasome-dependent degradation pathway. SEC63 is an integral membrane protein located in the rough ER.