Arg-Gly-Asp-Ser Peptid

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Hintergrund R-G-D-S, Arg-Gly-Asp-Ser, supports fibroblast attachment and inhibits fibronectin binding to platelets. It is the target sequence for syphilis spirochete adherence. RGDS increases ILK activity and the tyrosine phosphorylation of HMC proteins as well. In the case of tyrosine kinases, similar effects have been demonstrated in other cell types whereas the involvement of ILK, a serine-threonine kinase, in RGD effects has been less studied. To test the relevance of these two types of kinases in the stimulation of TGF-- synthesis by RGDS, activities were blocked by pharmacological or transfection means.
CAS-Nummer 91037-65-9
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Lagerung -20 °C
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 image for Arg-Gly-Asp-Ser peptide (ABIN399260) Arg-Gly-Asp-Ser peptide
Produkt verwendet in: Hanjaya-Putra, Shen, Wilson, Fox-Talbot, Khetan, Burdick, Steenbergen, Gerecht: "Integration and regression of implanted engineered human vascular networks during deep wound healing." in: Stem cells translational medicine, Vol. 2, Issue 4, pp. 297-306, 2013 (PubMed).

Hanjaya-Putra, Bose, Shen, Yee, Khetan, Fox-Talbot, Steenbergen, Burdick, Gerecht: "Controlled activation of morphogenesis to generate a functional human microvasculature in a synthetic matrix." in: Blood, Vol. 118, Issue 3, pp. 804-15, 2011 (PubMed).