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These results demonstrated that miR (zeige MLXIP Proteine)-145 has an inhibitory role in TNBC malignancy by targeting MMP11 (zeige MMP11 Proteine) and Rab27a, which might be potential therapeutic and diagnostic targets for TNBC.
RAB27A, RAB27B (zeige RAB27B Proteine) and VPS36 (zeige VPS36 Proteine) are frequently underexpressed in advanced prostate cancer and are inversely correlated with prostate cancer outcome. There seems to be a close relationship in the expression of RAB27A, RAB27B (zeige RAB27B Proteine) and VPS36 (zeige VPS36 Proteine), with RAB27A and RAB27B (zeige RAB27B Proteine) being dependent on VPS36 (zeige VPS36 Proteine).
identified small molecule inhibitors of Rab27a-JFC1 (zeige SYTL1 Proteine) binding that were also active in cell-based neutrophil-specific exocytosis assays, demonstrating the druggability of Rab (zeige HRB Proteine) GTPases and their effectors.
MicroRNA-134-3p is a novel potential inhibitor of human ovarian cancer stem cells by targeting RAB27A.
decreased expression of Rab27A and Rab27B (zeige RAB27B Proteine), especially Rab27A, closely correlated with tumor progression and are valuable prognostic indicators in colorectal cancer patients.
We report two unrelated teenagers with hemophagocytic lymphohistiocytosis and an identical heterozygous RAB27A mutation (c.259G-->C).
Data suggest that microRNA miR (zeige MLXIP Proteine)-582-5p may function as a tumor suppressor in the development of colorectal carcinoma (CRC (zeige CALR Proteine)) by targeting RAS-related GTP-binding protein (zeige RAB10 Proteine) (Rab27a), indicating a novel therapeutic strategy for patients with CRC (zeige CALR Proteine).
Experimental data are reviewed with a focus on the secretory Rab27 family of small GTPases and their implications in cancer progression.
miR (zeige MLXIP Proteine)-122 has a Rab27a-dependent function in the hepatitis C virus lifecycle
Rab27A may be used as a valuable prognostic biomarker for colorectal carcinoma patients.
miR (zeige MLXIP Proteine)-124 has an important role in osteoclastogenesis via targeting Rab27a.
this study shows that Rab27a and Rab27b (zeige RAB27B Proteine) double-knockout mice that are deficient in exosome secretion have a chronic, low-grade inflammatory phenotype characterized by elevated inflammatory cytokines and myeloproliferation
Rab27a is a possible target for intervention in inflammatory processes in which GM-CSF (zeige CSF2 Proteine)-dependent neutrophil priming is involved.
These results suggest that the dual effector, Noc2 (zeige RPH3AL Proteine), regulates the transition from Rab2a (zeige RAB2A Proteine)-mediated granule biogenesis to Rab27a-mediated granule exocytosis.
Loss of Rab3D (zeige RAB3D Proteine) from secretory vesicles, leading to disproportionate Rab27-to-Rab3D (zeige RAB3D Proteine) activity, may contribute to the enhanced release of cathepsin S (zeige CTSS Proteine) in tears of patients with Sjogren's syndrome.
The Rab27A regulates CG exocytosis following MII-stage oocyte activation.
Given that GTP (zeige AK3 Proteine)- and GDP-bound Rab27a regulate exocytosis.
This paper showed an inhibitory effect of Rab27a directly at the pore forming CaV1.3 (zeige CACNA1D Proteine) subunit of L-type channels, leading to decreased current density and reduced VEGF-A (zeige VEGFA Proteine) secretion by the retinal pigment epithelium.
The protein encoded by this gene belongs to the small GTPase superfamily, Rab family. The protein is membrane-bound and may be involved in protein transport and small GTPase mediated signal transduction. Mutations in this gene are associated with Griscelli syndrome type 2. Alternative splicing occurs at this locus and four transcript variants encoding the same protein have been identified.
RAB27A, member RAS oncogene family
, Ras-related protein Rab-27A
, rab27a, member ras oncogene family
, ras-related protein Rab-27A
, GTP-binding protein Ram
, member RAS oncogene family, RAB27A
, low Mr GTP-binding protein
, ram p25
, RAS oncogene family member