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Human KLF4 Protein expressed in Wheat germ - ABIN1308754
Rivero, Díaz-Guerra, Monsalve, Laborda, García-Ramírez: DLK2 is a transcriptional target of KLF4 in the early stages of adipogenesis. in Journal of molecular biology 2012
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Human KLF4 Protein expressed in HEK-293 Cells - ABIN2724292
Boxer, Barajas, Tao, Zhang, Khavari: ZNF750 interacts with KLF4 and RCOR1, KDM1A, and CTBP1/2 chromatin regulators to repress epidermal progenitor genes and induce differentiation genes. in Genes & development 2014
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This is, to our knowledge, the first report of decreased expression of TFF3 (zeige TFF3 Proteine), SPDEF, KLF4, and goblet cell population in the colon of patients with HSCR (zeige EDNRB Proteine). Altered goblet cell function may result in intestinal barrier dysfunction contributing to the development of HAEC.
KLF4 overcomes tamoxifen resistance by suppressing MAPK (zeige MAPK1 Proteine) signaling pathway and predicts good prognosis in breast cancer.
KLF4 activated the transcription activity of iNOS (zeige NOS2 Proteine) promoter in MH7A cells stimulated by TNF-alpha (zeige TNF Proteine). This study indicates that KLF4 is important for regulating the expression of iNOS (zeige NOS2 Proteine) by TNF-alpha (zeige TNF Proteine) in human synoviocytes.
Anaplastic thyroid cancer cells show high expression of KLF4, and KLF4 expression is necessary for maintaining the undifferentiated phenotype and drug resistance.
KLF4 could transcriptionally inhibit Cav-1 (zeige CAV1 Proteine) expression by binding directly to the promoter domain of Cav-1 (zeige CAV1 Proteine).
Impairment of IGF2 gene expression in prostate cancer is triggered by epigenetic dysregulation of IGF2-DMR0 and its interaction with KLF4
Data show that Kruppel like factor 4 (KLF4) was overexpressed in met proto-oncogene protein (c (zeige PROC Proteine)-Met)-overexpressing non-small-cell lung cancer (NSCLC) cells and tissues.
KLF4 may act as an administered indicator to assess whether adjuvant postoperative pharmaceutical therapy is needed for patients with colorectal cancer. Low KLF4 expression was significantly correlated with reductions of overall survival and recurrence rate.
Lower expression of KLF4 and NDRG2 (zeige NDRG2 Proteine) in colorectal cancer patients was correlated with poor overall survival. Thus, KLF4 inhibited the proliferation of colorectal cancer cells dependent on NDRG2 (zeige NDRG2 Proteine) signaling, which provides a novel strategy for therapy and early diagnosis of colorectal cancer.
KLF4 is downregulated in anaplastic meningioma compared with low-grade meningioma subtypes. By manipulating KLF4 expression in anaplastic meningioma stem-like cells, this study demonstrated that KLF4 acts as a tumor suppressor during malignant progression in meningioma, affecting apoptosis, proliferation, invasion, and cell cycle.
NF-kappaB (zeige NFKB1 Proteine) signaling in SMCs plays an important role in high phosphate-induced arterial medial calcification in CKD.
any one of Klf2 (zeige KLF2 Proteine), Klf4 and Klf5 (zeige KLF5 Proteine) was sufficient to support self-renewal of mouse embryonic stem cells, whereas the removal of all three compromised it.
miR (zeige MLXIP Proteine)-145 protects follicular granulosa cell against oxidative stress-induced (zeige SQSTM1 Proteine) apoptosis by targeting KLF4.
The results highlight a novel molecular mechanism underlying stability of neurogenesis-associated mRNAs controlled by the Klf4/Ddx5 (zeige DDX5 Proteine)/Stau1 (zeige STAU1 Proteine) axis during mammalian corticogenesis.
Analysis of tumor-infiltrating lymphocytes (TILs) demonstrated markedly increased activated CD8 (zeige CD8A Proteine) T cell numbers, and CD8 (zeige CD8A Proteine) T cell depletion obviated the inhibitory effect of myeloid Klf4 deletion on prostate cancer growth.
Spermatogonial stem cells and progenitors are refractory to reprogramming to pluripotency by the transcription factors Oct3/4 (zeige POU5F1 Proteine), c-Myc (zeige MYC Proteine), Sox2 (zeige SOX2 Proteine) and Klf4.
Based on these findings, we infer that MALAT1 is a transcriptional target of KLF4 in its protective role in cerebral MECs (zeige ISPF Proteine) after ischemic insult.
Folate receptor alpha (zeige FOLR1 Proteine) upregulates Oct4 (zeige POU5F1 Proteine), Sox2 (zeige SOX2 Proteine) and Klf4 and downregulates miR (zeige MLXIP Proteine)-138 and miR (zeige MLXIP Proteine)-let-7 in cranial neural crest cells.
overexpression of KLF4 promoted oligomeric Abeta42-induced neuroinflammation by exacerbating the release of pro-inflammatory factors
A long-range enhancer cluster controls Klf4 gene expression in mESCs
zebrafih Klf4a is essential for the repression of intestinal cell proliferation
Proper heart valve formation in zebrafish critically depends on protein kinase D2 (zeige PKD2 Proteine)-histone deacetylase 5 (zeige HDAC5 Proteine)-Kruppel-like factor signaling.
miR (zeige MYLIP Proteine)-92a coregulates KLF4 and KLF2 (zeige KLF2 Proteine) expression in arterial endothelium and contributes to phenotype heterogeneity associated with regional atherosusceptibility and protection in vivo.
Klf4 is transcribed both maternally and zygotically and the transcript is ubiquitous in embryos during germ-layer formation
a transcription factor that works with Sp1 to activate the Laminin gamma1 chain gene
Krueppel-like factor 4
, endothelial Kruppel-like zinc finger protein
, epithelial zinc finger protein EZF
, gut-enriched krueppel-like factor
, Kruppel-like factor 4 (Gut enriched kruppel-like factor) (Epithelial zinc-finger protein EZF)
, Kruppel-like transcription factor 4a
, Kruppel-like factor 4 (gut)
, Kruppel-like factor 4
, Kruppel-like transcription factor
, blood island enriched kruppel like factor