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Human KLF4 Protein expressed in Wheat germ - ABIN1308754
Rivero, Díaz-Guerra, Monsalve, Laborda, García-Ramírez: DLK2 is a transcriptional target of KLF4 in the early stages of adipogenesis. in Journal of molecular biology 2012
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Human KLF4 Protein expressed in HEK-293 Cells - ABIN2724292
Boxer, Barajas, Tao, Zhang, Khavari: ZNF750 interacts with KLF4 and RCOR1, KDM1A, and CTBP1/2 chromatin regulators to repress epidermal progenitor genes and induce differentiation genes. in Genes & development 2014
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Human and mouse WNT10A mutant palmoplantar and tongue epithelia also display specific differentiation defects that are mimicked by loss of the transcription factor KLF4.
The KLF4 might be a potential marker to predict prognosis in solid cancer patients.
SOX5 overexpression increased Kruppel-like factor 4 (KLF4) gene expression, which was decreased by SOX5 silencing. KLF4 knockdown abrogated the suppressive effect of SOX5 overexpression on osteogenic differentiation of hMSCs.
Results showed that SIRT1 interacts with and deacetylated KLF4. The deacetylation by SIRT1 promoted nuclear accumulation of KLF4 and enhanced the binding of KLF4 to the CLDN5 promoter in the nucleus.
miR-145 promotes hepatic stellate cell activation and liver fibrosis by targeting KLF4.
These findings identify a novel regulatory loop between miR-34a and KLF4 during keratinocytes replicative senescence.
Knockdown of KLF4 promoted the migration and invasion of nonsmallcell lung cancer (NSCLC) cells, whereas rescue of KLF4 expression reduced cell motion ability in miR25overexpressing NSCLC cells.
the subcellular localization of Klf4 might be related to the resistance of A549 cells to cisplatin.
Authors observed that saRNAs induced overexpression of KLF4 could promote cell migration/invasion in NCM460 and HCT116 cell lines.
This is, to our knowledge, the first report of decreased expression of TFF3, SPDEF, KLF4, and goblet cell population in the colon of patients with HSCR. Altered goblet cell function may result in intestinal barrier dysfunction contributing to the development of HAEC.
KLF4 overcomes tamoxifen resistance by suppressing MAPK signaling pathway and predicts good prognosis in breast cancer.
KLF4 activated the transcription activity of iNOS promoter in MH7A cells stimulated by TNF-alpha. This study indicates that KLF4 is important for regulating the expression of iNOS by TNF-alpha in human synoviocytes.
Anaplastic thyroid cancer cells show high expression of KLF4, and KLF4 expression is necessary for maintaining the undifferentiated phenotype and drug resistance.
KLF4 could transcriptionally inhibit Cav-1 expression by binding directly to the promoter domain of Cav-1.
Impairment of IGF2 gene expression in prostate cancer is triggered by epigenetic dysregulation of IGF2-DMR0 and its interaction with KLF4
Data show that Kruppel like factor 4 (KLF4) was overexpressed in met proto-oncogene protein (c-Met)-overexpressing non-small-cell lung cancer (NSCLC) cells and tissues.
KLF4 may act as an administered indicator to assess whether adjuvant postoperative pharmaceutical therapy is needed for patients with colorectal cancer. Low KLF4 expression was significantly correlated with reductions of overall survival and recurrence rate.
Lower expression of KLF4 and NDRG2 in colorectal cancer patients was correlated with poor overall survival. Thus, KLF4 inhibited the proliferation of colorectal cancer cells dependent on NDRG2 signaling, which provides a novel strategy for therapy and early diagnosis of colorectal cancer.
KLF4 is downregulated in anaplastic meningioma compared with low-grade meningioma subtypes. By manipulating KLF4 expression in anaplastic meningioma stem-like cells, this study demonstrated that KLF4 acts as a tumor suppressor during malignant progression in meningioma, affecting apoptosis, proliferation, invasion, and cell cycle.
KLF4 was a direct target of miR-212, and miR-212 repressed KLF4 expression in a post-transcriptional manner. Moreover, miR-212-mediated protection effects were abated following KLF4 expression restoration in MPP-induced SH-SY5Y cells, represented as lowered cell viability and enhanced apoptotic rate.
KLF4 indirectly modulates the actin cytoskeleton morphology via activity of RhoA in order to inhibit cellular migration and invasion.
Mule-mediated ubiquitination of the novel substrate KLF4 regulates T-cell proliferation, autoimmunity and antiviral immune responses.
miR-200b regulated adipocyte differentiation by directly targeting KLF4.
The data highlight Klf4 as an essential MCPIP1-dependent modulator of innate immunity that protects against excessive and self-destructive inflammation.
NF-kappaB signaling in SMCs plays an important role in high phosphate-induced arterial medial calcification in CKD.
any one of Klf2, Klf4 and Klf5 was sufficient to support self-renewal of mouse embryonic stem cells, whereas the removal of all three compromised it.
miR-145 protects follicular granulosa cell against oxidative stress-induced apoptosis by targeting KLF4.
The results highlight a novel molecular mechanism underlying stability of neurogenesis-associated mRNAs controlled by the Klf4/Ddx5/Stau1 axis during mammalian corticogenesis.
Analysis of tumor-infiltrating lymphocytes (TILs) demonstrated markedly increased activated CD8 T cell numbers, and CD8 T cell depletion obviated the inhibitory effect of myeloid Klf4 deletion on prostate cancer growth.
Spermatogonial stem cells and progenitors are refractory to reprogramming to pluripotency by the transcription factors Oct3/4, c-Myc, Sox2 and Klf4.
Based on these findings, we infer that MALAT1 is a transcriptional target of KLF4 in its protective role in cerebral MECs after ischemic insult.
Folate receptor alpha upregulates Oct4, Sox2 and Klf4 and downregulates miR-138 and miR-let-7 in cranial neural crest cells.
overexpression of KLF4 promoted oligomeric Abeta42-induced neuroinflammation by exacerbating the release of pro-inflammatory factors
A long-range enhancer cluster controls Klf4 gene expression in mESCs
we revealed that one of the key functions of KLF4-induced TCL1 during reprogramming is to promote the metabolic shift from oxidative phosphorylation to glycolysis.
KLF4 modulates development of BMI1-expressing intestinal stem cell-derived lineage following gamma-radiation-induced gut injury in mice.
dysregulation of Elovl6-driven long-chain fatty acid metabolism induces phenotypic switching of VSMC via ROS production and AMPK/KLF4 signaling that leads to growth arrest and downregulation of VSMC marker expression.
KLF2 and KLF4 serve as important regulators that promote hemoglobin alpha expression in the endothelium.
zebrafih Klf4a is essential for the repression of intestinal cell proliferation
Proper heart valve formation in zebrafish critically depends on protein kinase D2-histone deacetylase 5-Kruppel-like factor signaling.
miR-92a coregulates KLF4 and KLF2 expression in arterial endothelium and contributes to phenotype heterogeneity associated with regional atherosusceptibility and protection in vivo.
Klf4 is transcribed both maternally and zygotically and the transcript is ubiquitous in embryos during germ-layer formation
a transcription factor that works with Sp1 to activate the Laminin gamma1 chain gene
Krueppel-like factor 4
, endothelial Kruppel-like zinc finger protein
, epithelial zinc finger protein EZF
, gut-enriched krueppel-like factor
, Kruppel-like factor 4 (Gut enriched kruppel-like factor) (Epithelial zinc-finger protein EZF)
, Kruppel-like transcription factor 4a
, Kruppel-like factor 4 (gut)
, Kruppel-like factor 4
, Kruppel-like transcription factor
, blood island enriched kruppel like factor