Use your antibodies-online credentials, if available.
Keine Produkte auf Ihrer Vergleichsliste.
Ihr Warenkorb ist leer.
Weitere Synonyme anzeigen
Wählen Sie die gewünschte Spezies
Human KLF4 Protein expressed in Wheat germ - ABIN1308754
Rivero, Díaz-Guerra, Monsalve, Laborda, García-Ramírez: DLK2 is a transcriptional target of KLF4 in the early stages of adipogenesis. in Journal of molecular biology 2012
Show all 2 Pubmed References
Human KLF4 Protein expressed in HEK-293 Cells - ABIN2724292
Boxer, Barajas, Tao, Zhang, Khavari: ZNF750 interacts with KLF4 and RCOR1, KDM1A, and CTBP1/2 chromatin regulators to repress epidermal progenitor genes and induce differentiation genes. in Genes & development 2014
Show all 2 Pubmed References
zebrafih Klf4a is essential for the repression of intestinal cell proliferation
Proper heart valve formation in zebrafish critically depends on protein kinase D2 (zeige PKD2 Proteine)-histone deacetylase 5 (zeige HDAC5 Proteine)-Kruppel-like factor signaling.
Kruppel-like factor 4 (KLF4) inactivation in chronic lymphocytic leukemia correlates with promoter DNA-methylation (zeige HELLS Proteine) and can be reversed by inhibition of NOTCH (zeige NOTCH1 Proteine) signaling.
Data suggest that the Kruppel-like factor 4 (KLF4) /telomerase reverse transcriptase (zeige TERT Proteine) (hTERT)/MAPK (zeige MAPK1 Proteine) pathway is a potential new therapeutic target for lung cancer.
The expression of KLF4 was significantly increased in human osteosarcoma tissues compared with the normal tissues. Elevated KLF4 promoted human osteosarcoma cell proliferation and metastasis. Mechanistic studies revealed KLF4 specifically bound the promoter of CRYAB (zeige CRYAB Proteine) and upregulated CRYAB (zeige CRYAB Proteine) expression in human osteosarcoma cells.
In urothelial bladder carcinoma, strong KLF4 expression was associated with higher risk of metastasis and death. KLF4 positively correlates with TWIST1 (zeige TWIST1 Proteine) and vimentin (zeige VIM Proteine), and inversely with E-cadherin (zeige CDH1 Proteine). In vitro, it is accompanied by decreased E-cadherin (zeige CDH1 Proteine) and beta-catenin (zeige CTNNB1 Proteine), increased vimentin (zeige VIM Proteine) and fibronectin (zeige FN1 Proteine), and enhanced migration/invasion. KLF4 knockdown suppressed TWIST1 (zeige TWIST1 Proteine) expression and EMT (zeige ITK Proteine), migration and invasion.
TGF-beta1 (zeige TGFB1 Proteine) down-regulated KLF4 by activating miR (zeige MLXIP Proteine)-135a-5p, promoting proliferation and metastasis in hepatocellular carcinoma
our data suggest that KLF4 inhibits epithelial-mesenchymal transition -enhanced hepatocellular carcinoma growth and invasion
CSF (zeige CSF2 Proteine) and plasma expression of KLF4 mRNA was significantly decreased around 1-3 days after subarachnoid hemorrhage and remained lower than in controls.
PARP1 (zeige PARP1 Proteine) recruits KLF4 to activate telomerase expression and stem cell pluripotency, indicating a positive regulatory role of the PARP1 (zeige PARP1 Proteine)-KLF4 complex in telomerase expression in cancer and stem cells.
KLF2 (zeige KLF2 Proteine) and KLF4 serve as important regulators that promote hemoglobin alpha (zeige HBA1 Proteine) expression in the endothelium.
Loss of KLF4 expression is associated with T-cell acute lymphoblastic leukemia.
Klf4 is transcribed both maternally and zygotically and the transcript is ubiquitous in embryos during germ-layer formation
Folate receptor alpha (zeige FOLR1 Proteine) upregulates Oct4 (zeige POU5F1 Proteine), Sox2 (zeige SOX2 Proteine) and Klf4 and downregulates miR (zeige MLXIP Proteine)-138 and miR (zeige MLXIP Proteine)-let-7 in cranial neural crest cells.
overexpression of KLF4 promoted oligomeric Abeta42-induced neuroinflammation by exacerbating the release of pro-inflammatory factors
A long-range enhancer cluster controls Klf4 gene expression in mESCs
we revealed that one of the key functions of KLF4-induced TCL1 (zeige TCL1A Proteine) during reprogramming is to promote the metabolic shift from oxidative phosphorylation to glycolysis.
KLF4 modulates development of BMI1 (zeige BMI1 Proteine)-expressing intestinal stem cell-derived lineage following gamma-radiation-induced gut (zeige GUSB Proteine) injury in mice.
dysregulation of Elovl6-driven long-chain fatty acid metabolism induces phenotypic switching of VSMC via ROS (zeige ROS1 Proteine) production and AMPK (zeige PRKAA1 Proteine)/KLF4 signaling that leads to growth arrest and downregulation of VSMC marker expression.
KLF2 (zeige KLF2 Proteine) and KLF4 serve as important regulators that promote hemoglobin alpha (zeige HBA-A1 Proteine) expression in the endothelium.
Together, our results suggest that KLF4 regulates asthma development in a TSLP (zeige TSLP Proteine)- and fibrocyte-dependent manner.
Functional studies indicated that Klf4 mediates the self-renewal-promoting effects of Gbx2 (zeige GBX2 Proteine), because knockdown of Klf4 expression abrogated the ability of Gbx2 (zeige GBX2 Proteine) to maintain the undifferentiated state of mESCs.
miR (zeige MYLIP Proteine)-92a coregulates KLF4 and KLF2 (zeige KLF2 Proteine) expression in arterial endothelium and contributes to phenotype heterogeneity associated with regional atherosusceptibility and protection in vivo.
a transcription factor that works with Sp1 to activate the Laminin gamma1 chain gene
Krueppel-like factor 4
, Kruppel-like transcription factor 4a
, Kruppel-like factor 4 (gut)
, Kruppel-like factor 4
, endothelial Kruppel-like zinc finger protein
, epithelial zinc finger protein EZF
, gut-enriched krueppel-like factor
, Kruppel-like transcription factor
, blood island enriched kruppel like factor
, Kruppel-like factor 4 (Gut enriched kruppel-like factor) (Epithelial zinc-finger protein EZF)