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Human KLF4 Protein expressed in HEK-293 Cells - ABIN2724292
Boxer, Barajas, Tao, Zhang, Khavari: ZNF750 interacts with KLF4 and RCOR1, KDM1A, and CTBP1/2 chromatin regulators to repress epidermal progenitor genes and induce differentiation genes. in Genes & development 2014
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Human KLF4 Protein expressed in Wheat germ - ABIN1308754
Rivero, Díaz-Guerra, Monsalve, Laborda, García-Ramírez: DLK2 is a transcriptional target of KLF4 in the early stages of adipogenesis. in Journal of molecular biology 2012
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This is the first demonstration that dysregulated KLF4 expression associates with poor differentiation of pancreatic cancer. Epigenetic activation of miR (zeige MLXIP Proteine)-152/DNMT1 (zeige DNMT1 Proteine)/KLF4 signaling pathway by dietary DIM causes differentiation and significant growth inhibition of pancreatic cancer cells, highlighting its translational implications for pancreatic and other cancers.
The present study found that the KLF4 and KLF5 (zeige KLF5 Proteine) 3'-UTR contains one conserved target site of miR (zeige MLXIP Proteine)-506 and miR (zeige MLXIP Proteine)-124, and the overexpression of miR (zeige MLXIP Proteine)-506 and miR (zeige MLXIP Proteine)-124 inhibited the H2O2-induced upregulation of KLF4 and KLF5 (zeige KLF5 Proteine) in HCMs.
KLF4 enhances the sensitivity of cisplatin to ESCC cells through apoptosis induction and cell cycle arrest.
KLF4 was identified as an important regulatory factor in the host response to fungi and as a controlling element in the IL-6 (zeige IL6 Proteine) immune response with a unique expression pattern comparing fungal and lipopolysaccharide stimulation.
Here, the authors define WNT5A (zeige WNT5A Proteine), a non-canonical Wnt (zeige WNT2 Proteine) ligand implicated in epithelial differentiation, repair, and cancer, as a direct transcriptional target that is activated by KLF4 in squamous epithelial cells.
Results showed the expression levels of KLF4 were increased in bladder cancer (BC) patients which strongly correlated with the expression levels of PTBP1 (zeige PTBP1 Proteine) but inversely correlated with the expression level of miR (zeige MLXIP Proteine)-145. These findings suggest that KLF4 is likely to positively contribute to carcinogenesis in certain types of BC.
Transcriptional inhibition of MSI2 (zeige MSI2 Proteine) expression by KLF4 occurred in multiple PDAC cell lines as well as mouse models of PDAC. Lost expression of KLF4, a transcriptional repressor of MSI2 (zeige MSI2 Proteine) results in overexpression of MSI2 (zeige MSI2 Proteine) in PDACs, which may be a biomarker for accurate prognosis. A dysregulated KLF4/MSI2 (zeige MSI2 Proteine) signaling pathway promotes PDAC progression and metastasis.
the results of the present study demonstrated that by regulating KLF4, miR145 may be involved in regulating smooth muscle differentiation of ASCs induced by TGFbeta1 (zeige TGFB1 Proteine) and BMP4 (zeige BMP4 Proteine).
our findings reveal KLF4 as a key regulator of miR (zeige MLXIP Proteine)-182 cluster expression in hESCs and a main contributor to its aberrant expression in melanoma and potentially in other tumors
Surprisingly, 116 genes are directly activated via mCpG-dependent KLF4 binding activity. In-depth mechanistic studies reveal that recruitment of KLF4 to the methylated cis (zeige CISH Proteine)-regulatory elements of these genes result in chromatin remodeling and transcription activation.
miR (zeige MLXIP Proteine)-145 protects follicular granulosa cell against oxidative stress-induced (zeige SQSTM1 Proteine) apoptosis by targeting KLF4.
The results highlight a novel molecular mechanism underlying stability of neurogenesis-associated mRNAs controlled by the Klf4/Ddx5 (zeige DDX5 Proteine)/Stau1 (zeige STAU1 Proteine) axis during mammalian corticogenesis.
Analysis of tumor-infiltrating lymphocytes (TILs) demonstrated markedly increased activated CD8 (zeige CD8A Proteine) T cell numbers, and CD8 (zeige CD8A Proteine) T cell depletion obviated the inhibitory effect of myeloid Klf4 deletion on prostate cancer growth.
Spermatogonial stem cells and progenitors are refractory to reprogramming to pluripotency by the transcription factors Oct3/4 (zeige POU5F1 Proteine), c-Myc (zeige MYC Proteine), Sox2 (zeige SOX2 Proteine) and Klf4.
Based on these findings, we infer that MALAT1 is a transcriptional target of KLF4 in its protective role in cerebral MECs (zeige ISPF Proteine) after ischemic insult.
Folate receptor alpha (zeige FOLR1 Proteine) upregulates Oct4 (zeige POU5F1 Proteine), Sox2 (zeige SOX2 Proteine) and Klf4 and downregulates miR (zeige MLXIP Proteine)-138 and miR (zeige MLXIP Proteine)-let-7 in cranial neural crest cells.
overexpression of KLF4 promoted oligomeric Abeta42-induced neuroinflammation by exacerbating the release of pro-inflammatory factors
A long-range enhancer cluster controls Klf4 gene expression in mESCs
we revealed that one of the key functions of KLF4-induced TCL1 (zeige TCL1A Proteine) during reprogramming is to promote the metabolic shift from oxidative phosphorylation to glycolysis.
KLF4 modulates development of BMI1 (zeige BMI1 Proteine)-expressing intestinal stem cell-derived lineage following gamma-radiation-induced gut (zeige GUSB Proteine) injury in mice.
zebrafih Klf4a is essential for the repression of intestinal cell proliferation
Proper heart valve formation in zebrafish critically depends on protein kinase D2 (zeige PKD2 Proteine)-histone deacetylase 5 (zeige HDAC5 Proteine)-Kruppel-like factor signaling.
miR (zeige MYLIP Proteine)-92a coregulates KLF4 and KLF2 (zeige KLF2 Proteine) expression in arterial endothelium and contributes to phenotype heterogeneity associated with regional atherosusceptibility and protection in vivo.
Klf4 is transcribed both maternally and zygotically and the transcript is ubiquitous in embryos during germ-layer formation
a transcription factor that works with Sp1 to activate the Laminin gamma1 chain gene
Krueppel-like factor 4
, endothelial Kruppel-like zinc finger protein
, epithelial zinc finger protein EZF
, gut-enriched krueppel-like factor
, Kruppel-like factor 4 (Gut enriched kruppel-like factor) (Epithelial zinc-finger protein EZF)
, Kruppel-like transcription factor 4a
, Kruppel-like factor 4 (gut)
, Kruppel-like factor 4
, Kruppel-like transcription factor
, blood island enriched kruppel like factor