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These data suggest that activin-follistatin regulation may play a role during the development of Experimental autoimmune epididymo-orchitis.
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Inflammatory stimuli strongly induce Smad2 and Smad5 phosphorylation in wild-type mice. None of these Smad effectors are activated in mice deficient in activin B. Activin B, whose messenger RNA expression is strongly induced after LPS administration or E coli infection, is required for activation of Smad1/5/8 signaling. Hepcidin expression did not depend on activin B expression.
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These results suggest that prolonged exposure to hyperglycemia in the Ins2(Akita+/-) mice leads to progressive testicular disruption mediated by testicular activin activity, rather than hormonal dysregulation.
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This study tested the hypothesis that inhibins act in an autocrine manner on Leydig cells using a pre-pubertal Leydig cell line, TM3, as a model of immature Leydig cells.
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Menin binds on the promoter of Inhbb gene where it favours the recruitment of Ezh2 via an indirect mechanism involving Akt-phosphorylation.
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Data suggest Inhbb is physiologically essential for early folliculogenesis; Inhbb appears to participate in regulation of cell cycle progression, apoptosis, and steroidogenesis (estradiol/progesterone synthesis) in ovarian granulosa cells in culture.
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Activin B, a transforming growth factor beta - related ligand, is upregulated during tumorigenesis and drives the loss of insulin expression and beta-cell maturity in a mouse insulinoma model.
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in mammalian spinal cord, Tgfbeta ligands and ActB together support oligodendrocyte development and myelin formation
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No differences were observed in fasting glucose/insulin levels, glucose tolerance, insulin sensitivity, or insulin secretion in comparing young or older males on in comparing insulin secretion from islets of wild type or activin B knockout males.
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There is a dramatic induction of Inhbb mRNA, encoding the activin beta(B)-subunit, in liver challenged with lipopolysaccharide, slightly preceding an increase in Smad1/5/8 phosphorylation and Hamp mRNA.
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the transition between stem cells and committed progenitors is neither sharp nor irreversible and GDF11, ACTbetaB and FST are crucial components of a circuit that controls both total cell number and the ratio of neuronal versus glial cells in this system
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These data support the role of proconvertase PCSK5 in the processing of ovarian inhibin subunits during folliculogenesis.
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Maintenance of female germ cells hinge upon a delicate balance between positive (WNT4 and beta-catenin) and negative (activin betaB) regulators derived from the somatic cells in the fetal ovary.
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Inhbb-deficient mice have failure of eyelid fusion at birth and demonstrate more severe effects on somatic growth and survival.
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Activin affects both stromal cells and keratinocytes in normal and wounded skin, and the effect on keratinocytes is dose-dependent in vivo.
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inhibins A and B differentially antagonize the actions of activins and BMPs to control adrenocortical C(19) steroid production
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ALK7 plays an important role in regulating the functional plasticity of pancreatic islets, negatively affecting beta-cell function by mediating the effects of activin B on Ca(2+) signaling