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The present study demonstrated that EGF (zeige EGF Proteine) controlled expression of three activin subunits (inhbaa (zeige INHBA Proteine), inhbab and inhbb) in the follicle cells via diverse signaling pathways.
whereas the inhibitory effect of hCG (zeige CGA Proteine) on activin betaB expression is likely mediated by PKA-independent pathway(s).
Activin betaA is involved in promoting ovary and follicle growth, whereas activin betaB may have a tonic role throughout follicle development but becomes critical at the late stage of oocyte maturation and/or ovulation.
point mutation enhances the affinity of Noggin2 to ActivinB, while weakens its affinity to BMP.
Noggin2 protected the developing forebrain from inhibition by Activin B and XWnt8 (zeige WNT8A Proteine) signaling.
A new role for activin B during gastrulation involves cell cycle arrest in the involuting dorsal axial mesoderm.
Used monoclonal antibody to xenopus laevis Inhbb in ELISA for detection of human Inhbb.
These data suggest that activin-follistatin (zeige FST Proteine) regulation may play a role during the development of Experimental autoimmune epididymo-orchitis.
Inflammatory stimuli strongly induce Smad2 and Smad5 phosphorylation in wild-type mice. None of these Smad effectors are activated in mice deficient in activin B. Activin B, whose messenger RNA expression is strongly induced after LPS administration or E coli infection, is required for activation of Smad1/5/8 signaling. Hepcidin expression did not depend on activin B expression.
These results suggest that prolonged exposure to hyperglycemia in the Ins2(Akita+/-) mice leads to progressive testicular disruption mediated by testicular activin activity, rather than hormonal dysregulation.
This study tested the hypothesis that inhibins act in an autocrine manner on Leydig cells using a pre-pubertal Leydig cell line, TM3 (zeige TPM1 Proteine), as a model of immature Leydig cells.
Menin binds on the promoter of Inhbb gene where it favours the recruitment of Ezh2 (zeige EZH2 Proteine) via an indirect mechanism involving Akt (zeige AKT1 Proteine)-phosphorylation.
Data suggest Inhbb is physiologically essential for early folliculogenesis; Inhbb appears to participate in regulation of cell cycle progression, apoptosis, and steroidogenesis (estradiol/progesterone synthesis) in ovarian granulosa cells in culture.
Activin B, a transforming growth factor beta - related ligand, is upregulated during tumorigenesis and drives the loss of insulin (zeige INS Proteine) expression and beta-cell maturity in a mouse insulinoma (zeige RPS15 Proteine) model.
in mammalian spinal cord, Tgfbeta (zeige TGFB1 Proteine) ligands and ActB (zeige ACTB Proteine) together support oligodendrocyte development and myelin formation
No differences were observed in fasting glucose/insulin levels, glucose tolerance, insulin sensitivity, or insulin secretion in comparing young or older males on in comparing insulin secretion from islets of wild type or activin B knockout males.
There is a dramatic induction of Inhbb mRNA, encoding the activin beta(B)-subunit, in liver challenged with lipopolysaccharide, slightly preceding an increase in Smad1 (zeige SMAD1 Proteine)/5/8 phosphorylation and Hamp (zeige HAMP Proteine) mRNA.
Results found that INHBB expression was reduced in nasopharyngeal carcinoma (NPC (zeige NPC1 Proteine)) tissues, and associated with lymph node metastasis. Further data revealed that INHBB could suppress anoikis resistance and migration of NPC (zeige NPC1 Proteine) cells by the TGF-beta (zeige TGFB1 Proteine) signaling pathway, decrease p53 (zeige TP53 Proteine) overexpression, and could serve as a potential biomarker for NPC (zeige NPC1 Proteine) metastasis and prognosis .
Presence of varicocele was associated with lower serum inhibin B.
Elevated activin B levels together with normal activin A (zeige INHBA Proteine) levels identified patients with the diagnostic symptoms of chronic fatigue syndrome/myalgic encephalomyelitis.
Results identified Inhbb as one factor mediating the proliferative effect of Pdx-1 (zeige PDX1 Proteine) on islet cells.
Low activin B level is associated with tubal ectopic pregnancy.
The Sertoli cell hormones inhibin-B and anti Mullerian hormone (zeige AMH Proteine) have different patterns of secretion in prepubertal cryptorchid boys.
Pregnant Han Chinese women carrying the rs7579169 CC genotype and G-G-C haplotype are significantly more likely to develop pre-eclampsia, especially late-onset and multiparous cases.
We report here an original observation that activin-B is upregulated in the human idiopathic pulmonary fibrosis lung.
reduction of RhoA (zeige RHOA Proteine) signaling by Activin B together with persistent Rac1 activity is a prerequisite for inducing an invasive phenotype in clear cell renal cell carcinoma (zeige MOK Proteine).
inhibin B and anti-Mullerian hormone (zeige AMH Proteine) serum concentrations did not provide an additional diagnostic tool for male infertility
An increased expression of Inhibin-beta B was found in oocytes collected from large and medium follicles compared with small follicles before or after in oocyte vitro maturation.
our data indicate that miR (zeige MYLIP Proteine)-34a plays an important role in granulosa cell apoptosis by targeting the INHBB gene in the porcine ovary
results indicated that boar testis produces inhibin A and inhibin B during the infantile period but inhibin A is the predominant form towards puberty and molecular weight forms of inhibin and the sites of production change with testicular development
The inhibin beta B subunit joins the alpha subunit to form a pituitary FSH secretion inhibitor. Inhibin has been shown to regulate gonadal stromal cell proliferation negatively and to have tumour-suppressor activity. In addition, serum levels of inhibin have been shown to reflect the size of granulosa-cell tumors and can therefore be used as a marker for primary as well as recurrent disease. Because expression in gonadal and various extragonadal tissues may vary severalfold in a tissue-specific fashion, it is proposed that inhibin may be both a growth/differentiation factor and a hormone. Furthermore, the beta B subunit forms a homodimer, activin B, and also joins with the beta A subunit to form a heterodimer, activin AB, both of which stimulate FSH secretion.
activin beta B
, activin B
, activin beta B subunit
, inhibin, beta B
, inhibin beta B
, inhibin, beta B (activin AB beta polypeptide)
, inhibin beta B chain-like
, activin beta-B chain
, activin betaB
, inhibin beta B chain
, inhibin beta subunit B
, Inhibin, beta-2
, activin AB beta polypeptide
, inhibin beta-(b) subunit
, betaB inhibin/activin
, inhibin beta B subunit