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These results provide evidence that CDX2 plays an essential role in functional trophectoderm formation during primate embryonic development.
The results of the present study show that a lack of CDX2 expression in metastatic colorectal cancer is an adverse prognostic feature and a potential negative predictor of the response to chemotherapy.
We may conclude that hTERT promotes GIM by up-regulating CDX2 via NF-kappaB (zeige NFKB1 Proteine) signaling pathway.
Our work suggests that combination of the consensual CMS (zeige Cd2ap Proteine) classification and lack of CDX2 expression could be a useful marker to identify CMS4/CDX2-negative patients with a very poor prognosis
AMPK (zeige PRKAA1 Proteine) enhances intestinal barrier function and epithelial differentiation via promoting CDX2 expression, which is partially mediated by altered histone modifications in the Cdx2 promoter.
Findings suggest that H. pylori infectionis a driving force of gastric cardia carcinogenesis by upregulating caudal-related homeobox (zeige Lbx1 Proteine) transcription factor 2 (zeige HNF1B Proteine) (CDX2) and inducing inflammation.
Data show that a two-marker panel of p40 (zeige IL9 Proteine) (DeltaNp63) and CDX2 is highly sensitive and specific.
our findings demonstrated that MDR1 expression is regulated by CDX2 and is related to drug resistance in ovarian mucinous adenocarcinoma.
The data presented provide a novel insight into how CDX2 is implicated in the transcriptional regulation of LAMC2 (zeige LAMC2 Proteine) in intestinal epithelial cells, a function that is impaired during mucosal inflammation where a high level of TNF-alpha (zeige TNF Proteine) is present.
Cytapheresis might induce CDX2 expression without affecting the cell proliferation, thus resulting in mucosal healing with goblet cell restoration.
SOX2 (zeige SOX2 Proteine) expression induces a cellular stem cell state in human colorectal cancer (CRC (zeige CALR Proteine)) with a decreased expression of CDX2. Furthermore, a down-regulated expression of CDX2 results in a poor patient prognosis in CRC (zeige CALR Proteine).
Data show that SLC7A7 (zeige Slc7a7 Proteine) is a CDX2 target gene, and that CDX2 binds directly to the SLC7A7 (zeige Slc7a7 Proteine) promoter.
these results provide further insight into the functional diversity of CDX2 in early mammalian embryos.
showed novel molecular regulation of CDX2 on Oct4 (zeige POU5F1 Proteine), and provided important clues for clarifying the mechanism of interaction between CDX2 and Oct4 (zeige POU5F1 Proteine) in embryo of mammals other than mouse
Results reveal an early regulatory switch in Cdx2 expression and show that different inputs are needed to drive Cdx2 expression in the blastocyst trophectoderm and in trophoblast stem cells.
CDX2(Null)/BRAF (zeige BRAF Proteine)(V600E) expression in adult mouse intestinal epithelium led to serrated morphology tumors (including carcinomas) and BRAF (zeige BRAF Proteine)(V600E) potently interacted with CDX2 silencing to alter gene expression. Like human serrated lesions, CDX2(Null)/BRAF (zeige BRAF Proteine)(V600E)-mutant epithelium expressed gastric markers.
including Wnt (zeige WNT2 Proteine) and Fgf pathway components active in the axial progenitor niche. Our data demonstrate that integration of the Cdx (zeige CDX1 Proteine)/Hox (zeige MSH2 Proteine) and T Brachyury (zeige TBX1 Proteine) transcriptional networks controls differential axial growth during vertebrate trunk elongation
A new organ culture system for adult murine oesophagus is described. Using this, Cdx2 and HNF4alpha (zeige HNF4A Proteine) were ectopically expressed by adenoviral infection. We demonstrate the expression of CDX2 and HNF4alpha (zeige HNF4A Proteine) in human biopsy samples.
Cdx (zeige CDX1 Proteine) members interact with the SWI (zeige SMARCA1 Proteine)-SNF (zeige SNRPA Proteine) complex and make direct contact with Brg1 (zeige SMARCA4 Proteine), a catalytic member of SWI (zeige SMARCA1 Proteine)-SNF (zeige SNRPA Proteine). Both Cdx2 and Brg1 (zeige SMARCA4 Proteine) co-occupy a number of Cdx (zeige CDX1 Proteine) target genes, and both factors are necessary for transcriptional regulation of such targets. Finally, Cdx2 and Brg1 (zeige SMARCA4 Proteine) occupancy occurs coincident with chromatin remodeling at some of these loci.
The authors identify a Cdx2-responsive segment of HoxA, immediately 5' to the recently defined regulatory domain orchestrating initial transcription of the first Hox (zeige MSH2 Proteine) gene.
Cdx1 (zeige CDX1 Proteine)-Cdx2 double null mutants exhibited loss of primitive erythroblasts, aberrant vascular remodelling of the yolk sac (zeige ADCY10 Proteine) and a block in hematopoietic differentiation from yolk sac (zeige ADCY10 Proteine)-derived cells in culture.
this study shows that Aloe vera (zeige IGF2BP3 Proteine) gel suppresses colitis-related colon carcinogenesis via increased expression of CDX-2, a tumor suppressor in colorectal cancer
Results point out the complex interplay between the DSB DNA repair activity and the homeoproteins HoxB7 (zeige HOXB7 Proteine) and Cdx2 in colon cancer cells.
results thus indicate that CDX2 is not required for TE formation during bovine development; nevertheless, it is necessary for maintaining TE integrity.
This gene is a member of the caudal-related homeobox transcription factor gene family. The encoded protein is a major regulator of intestine-specific genes involved in cell growth an differentiation. This protein also plays a role in early embryonic development of the intestinal tract. Aberrant expression of this gene is associated with intestinal inflammation and tumorigenesis.
caudal type homeobox 2
, caudal type homeobox transcription factor 2
, caudal type homeo box transcription factor 2
, homeobox protein CDX-2
, caudal-type homeobox protein 2
, caudal type homeo box 2
, caudal-type homeobox transcription factor 2