CD3 FITC - CD28 PE Bi-Test Reagent
FACS
Reaktivität: Human
FACS
FITC,PE
Wirt: Maus
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- Target
- CD3, CD28
- Reaktivität
- Human
- Wirt
- Maus
- Konjugat
- FITC,PE
- Applikation
- Flow Cytometry (FACS)
- Marke
- Bi-Test™
- Aufreinigung
- Protein A/G Chromatography
- Isotyp
- IgG1
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- Beschränkungen
- Nur für Forschungszwecke einsetzbar
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- Lagerung
- 4 °C
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- Target
- CD3, CD28
- Hintergrund
- The CD3 epitope is expressed on the epsilon chain of the CD3/T cell antigen receptor (TcR) complex. CD3 is expressed on 65-85 % of thymocytes and has a mitogenic effect on peripheral blood T cells. Identification of human T cells expressing the 22-28,000 M. W. surface antigen. Antihuman CD28 binds the 44 kDa MW cell surface protein on the surface of most T cells. CD28 acts as the ligand for the B7/BB-1 Molecule on the surface of activated B cells. B7/BB-1 co-stimulates T cells through CD28, along with CD2 and CD3. CD28 antigen is a disulfide-linked homodimeric glycoprotein. The CD28 antigen is present on approximately 60 %-80 % 0flymphocytes (95 % of CD4 and 50 % of CD8 lymphocytes). CD28 regulates the expression of cytokines by T cells, not only IL-2, but also IL-1 alpha and CSF-1, usually synthesized by accessory cells. CD28 functions as a cell adhesion molecule (CAM) for certain T cell subsets.
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