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anti-Human TWIST1 Antikörper:
anti-Mouse (Murine) TWIST1 Antikörper:
anti-Rat (Rattus) TWIST1 Antikörper:
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Human Monoclonal TWIST1 Primary Antibody für ICC, IF - ABIN2668516
Ezponda, Popovic, Shah, Martinez-Garcia, Zheng, Min, Will, Neri, Kelleher, Yu, Licht: The histone methyltransferase MMSET/WHSC1 activates TWIST1 to promote an epithelial-mesenchymal transition and invasive properties of prostate cancer. in Oncogene 2013
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Human Monoclonal TWIST1 Primary Antibody für IP, RNAi - ABIN563296
Saito, Murata-Kamiya, Hirayama, Ohba, Hatakeyama: Conversion of Helicobacter pylori CagA from senescence inducer to oncogenic driver through polarity-dependent regulation of p21. in The Journal of experimental medicine 2010
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Human Monoclonal TWIST1 Primary Antibody für ELISA, WB - ABIN1098133
Yu, Li, Lu, Tian, Ma, Wang, Xu: Down-regulation of TWIST decreases migration and invasion of laryngeal carcinoma Hep-2 cells by regulating the E-cadherin, N-cadherin expression. in Journal of cancer research and clinical oncology 2011
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Human Polyclonal TWIST1 Primary Antibody für IHC (p), IHC - ABIN189738
Jin, Ren, Macarak, Rosenbloom et al.: Pathobiological mechanisms of peritoneal adhesions: The mesenchymal transition of rat peritoneal mesothelial cells induced by TGF-β1 and IL-6 requires activation of Erk1/2 and Smad2 linker region ... in Matrix biology : journal of the International Society for Matrix Biology 2016
Human Monoclonal TWIST1 Primary Antibody für IP, ELISA - ABIN521172
Cosset, Hamdan, Jeanpierre, Voeltzel, Sagorny, Hayette, Mahon, Dumontet, Puisieux, Nicolini, Maguer-Satta: Deregulation of TWIST-1 in the CD34+ compartment represents a novel prognostic factor in chronic myeloid leukemia. in Blood 2011
Cow (Bovine) Polyclonal TWIST1 Primary Antibody für IHC, WB - ABIN2780347
Reinhold, Kapadia, Liao, Naski: The Wnt-inducible transcription factor Twist1 inhibits chondrogenesis. in The Journal of biological chemistry 2006
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Human Polyclonal TWIST1 Primary Antibody für CyTOF, FACS - ABIN4898987
Satelli, Mitra, Brownlee, Xia, Bellister, Overman, Kopetz, Ellis, Meng, Li: Epithelial-mesenchymal transitioned circulating tumor cells capture for detecting tumor progression. in Clinical cancer research : an official journal of the American Association for Cancer Research 2015
Human Monoclonal TWIST1 Primary Antibody für ICC, FACS - ABIN1724845
Weiss, Abel, Mayberry, Basile, Berger, Aplin: TWIST1 is an ERK1/2 effector that promotes invasion and regulates MMP-1 expression in human melanoma cells. in Cancer research 2012
Frame-shift mutation in TWIST1 is associated with type 2 scurs syndrome.
Interaction with Snail1/2, and Twist function more generally, is regulated by GSK-3-beta-mediated phosphorylation of conserved sites in the WR domain.
Three SNPs were associated with survival: rs2526614 (TWIST1) (genotype CA + AA, adjusted HR=0.58, 95%CI=0.37-0.93), rs6953766 (TWIST1) (genotype GG, crude HR=2.02, 95%CI=1.06-3.82, adjusted HR=2.14, 95%CI=1.07-4.25), and rs431073 (ZEB1 (zeige ZEB1 Antikörper)) (genotype AC + CC, crude HR=1.62, 95%CI=1.01-2.59, adjusted HR=1.96, 95%CI=1.18-3.25).
Study shows that molecular dynamic simulations provide a structural explanation for the loss-of-function associated with the Saethre-Chotzen syndrome TWIST1 mutation and provides a proof of concept of the predictive value of these MD simulations; MD simulations highlighted a clear decrease in the stability of the alpha-helix during the dimerization of the mutated R154P TWIST1/E12 (zeige ELSPBP1 Antikörper) dimer compared to the wild-type TE comp (zeige COMP Antikörper)...
Basic performance testing showed that the combined restriction digital PCR assay enabled detection of 0.14% of the TWIST1 methylation level for the lymphocyte DNA
Overexpressed TWIST1 can be correlated with upregulation of the cancer stem cell marker OCT4 (zeige POU5F1 Antikörper) and the protein may play critical regulatory role in OCT4 (zeige POU5F1 Antikörper) gene expression.
Study provides evidence that upregulation of the Twist gene promotes EMT (zeige ITK Antikörper) molecular events and enhances the metastatic ability of colon tumor cells, while Twist-shRNA effectively silences Twist gene expression in the HCT116 cell line, promoting mesenchymalepithelial transition and effectively inhibiting colon cancer cell migration and invasion.
demonstrate that miR (zeige MLXIP Antikörper)-326 served as a tumor suppressor by targeting TWIST1, and may serve as a biomarker or therapeutic target for patients with EC.
CRP (zeige CRP Antikörper) bound to surface CD32 (also known as FcgammaRII) on myeloma cells, which activated a pathway mediated by the kinase p38 MAPK (zeige MAPK14 Antikörper) and the transcription factor Twist that enhanced the cells' secretion of osteolytic cytokines.
The findings suggest that AEG-1 (zeige MTDH Antikörper) promotes gastric cancer metastasis through upregulation of eIF4E (zeige EIF4E Antikörper)-mediated MMP-9 (zeige MMP9 Antikörper) and Twist.
The aggresome formation of the Twist1 deletion mutants was confirmed by counterstaining with known aggresome markers: Vimentin (zeige VIM Antikörper), HDAC6 (zeige HDAC6 Antikörper), and gamma tubulin (zeige TUBG1 Antikörper) and further validated by MG-132 treatment. In addition, it was found that the aggresomes generated by the Twist1Delta30-46 construct are more stable than the aggresome produced by the Twist1Delta47-100 construct as well as the wild-type Twist1 protein.
These studies identified harmine as a first-in-class TWIST1 inhibitor with marked anti-tumor activity in oncogene-driven non-small cell lung cancer (NSCLC)including EGFR mutant, KRAS mutant and MET altered NSCLC
This study evaluated the role of Twist1 in the expression of other epithelial-mesenchymal transition transcription factors in tumor cells, including tumor progression, intravasation, and metastasis.
The authors demonstrate that Twist1 serine (Ser (zeige SIGLEC1 Antikörper)) 42 phosphorylation is required for endothelial-to-mesenchymal transition through TGF-beta (zeige TGFB1 Antikörper)-Smad (zeige SMAD1 Antikörper) signaling in vitro and in the mouse lung gel implantation system.
Overall, hypoxia-induced activation of Twist/miR (zeige MLXIP Antikörper)-214/E-cadherin (zeige CDH1 Antikörper) axis is involved in the EMT (zeige ITK Antikörper) of TECs, and anti-miR (zeige MLXIP Antikörper)-214 may be an attractive strategy to ameliorate the progression of renal fibrosis.
molecular and cellular processes that regulate dural Cerebral vein development in mammals and describe venous malformations in humans with craniosynostosis and TWIST1 mutations that are recapitulated in mouse models, are reported.
Methyltransferase G9A (zeige EHMT2 Antikörper) Regulates Osteogenesis via Twist Gene Repression in mice.
this study shows that loss of Twist1 in collagen-producing cells leads to increased bleomycin-induced pulmonary fibrosis, which is mediated by increased expression of CXCL12 (zeige CXCL12 Antikörper)
RNF8 (zeige RNF8 Antikörper)-promoted Twist ubiquitination is required for Twist localization to the nucleus for subsequent epithelial-mesenchymal transition and cancer stem cells functions, thereby conferring chemoresistance.
These results indicate that Twist1 Ser42 phosphorylation contributes to the pathogenesis of bleomycin-induced pulmonary fibrosis through angiopoietin-Tie2 (zeige TEK Antikörper) signaling.
the mesenchymal properties of the cranial mesoderm are likely to be regulated by a network of TWIST1 targets that influences the extracellular matrix and cell-matrix interactions, and collectively they are required for the morphogenesis of the craniofacial structures.
TWIST1 expression promotes developmental angiogenesis by inducing endothelial cell proliferation and migration.
the ventral migration of Cranial neural crest cells (CNCCs) away from a source of Bmps in the dorsal ectoderm promotes ectomesenchyme development by relieving Id2a-dependent repression of Twist1 function.
twist1a and twist1b control skeletal development and dorsoventral patterning by regulating runx2b in zebrafish
These observations are consistent with a role for twist1 in craniofacial, vertebral, and early renal development.
Basic helix-loop-helix (bHLH) transcription factors have been implicated in cell lineage determination and differentiation. The protein encoded by this gene is a bHLH transcription factor and shares similarity with another bHLH transcription factor, Dermo1. The strongest expression of this mRNA is in placental tissue\; in adults, mesodermally derived tissues express this mRNA preferentially. Mutations in this gene have been found in patients with Saethre-Chotzen syndrome.
twist homolog 1
, twist transcription factor
, twist homolog 1 (acrocephalosyndactyly 3; Saethre-Chotzen syndrome)
, hypothetical protein
, twist-like protein
, twist-related protein 1
, twist-related protein
, B-HLH DNA binding protein
, TWIST homolog of drosophila
, class A basic helix-loop-helix protein 38
, charlie chaplin
, polydactyly EMS
, twist gene homolog 1
, twist 1
, twist homolog 1 (Drosophila)