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Results revealed that PIG3 (zeige MRPL41 Antikörper) expression levels positively correlated with poor prognosis of non-small cell lung cancer (NSCLC) patients and indicate that PIG3 (zeige MRPL41 Antikörper) promotes NSCLC progression.
Data suggest that PIG3 (zeige MRPL41 Antikörper) was involved in HIF-1alpha (zeige HIF1A Antikörper) regulation, and indicate a signaling pathway of PIG3 (zeige MRPL41 Antikörper)/HIF-1alpha (zeige HIF1A Antikörper) in the regulation of cell migration in renal cell carcinoma (zeige MOK Antikörper).
our data suggest that high expression of p53 (zeige TP53 Antikörper)-inducible gene 3 is significant for glioblastoma inhibition and p53 (zeige TP53 Antikörper)-inducible gene 3 independently indicates good prognosis in patients, which might be a novel prognostic biomarker or potential therapeutic target in glioblastoma.
Data indicate that knockdown of p53 (zeige TP53 Antikörper)-induced gene 3 (PIG-3 (zeige MRPL41 Antikörper)) expression by small interfering RNA (siRNA) treatment can inhibit the generation of reactive oxygen species (ROS (zeige ROS1 Antikörper)).
The results suggested that PIG3 (zeige MRPL41 Antikörper) plays an oncogenic role in PTC (zeige F9 Antikörper) via the regulation of the PI3K (zeige PIK3CA Antikörper)/AKT (zeige AKT1 Antikörper)/PTEN pathway and support the exploration of PIG3 (zeige MRPL41 Antikörper) as a novel biomarker for patients with papillary thyroid carcinoma
PIG3 (zeige MRPL41 Antikörper), which functions in DNA damage repair, uses an unexpected catalytic mechanism to suppress Rho-ROCK activity and impair tumor invasion in vivo. This regulation was suppressed by antioxidants.
prohibitin (zeige PHB Antikörper) and prohibiton (PHB2 (zeige PHB2 Antikörper)) contribute to PIG3 (zeige MRPL41 Antikörper)-mediated apoptosis by binding to the PIG3 (zeige MRPL41 Antikörper) promoter (TGYCC)15 motif
study provides evidence that the variant genotypes of (TGYCC)n repeats in the PIG3 (zeige MRPL41 Antikörper) promoter are functional and associated with risk of squamous cell carcinoma of the head and neck in a non-Hispanic white population
a novel signaling pathway of GPx3 (zeige GPX3 Antikörper)-PIG3 (zeige MRPL41 Antikörper) in the regulation of cell death in prostate cancer.
certain p53 (zeige TP53 Antikörper) mutatants activate PIG3 (zeige MRPL41 Antikörper), whereas the result of our study show increased full-length transcript expression in tumor counterparts
The protein encoded by this gene is similar to oxidoreductases, which are enzymes involved in cellular responses to oxidative stresses and irradiation. This gene is induced by the tumor suppressor p53 and is thought to be involved in p53-mediated cell death. It contains a p53 consensus binding site in its promoter region and a downstream pentanucleotide microsatellite sequence. P53 has been shown to transcriptionally activate this gene by interacting with the downstream pentanucleotide microsatellite sequence. The microsatellite is polymorphic, with a varying number of pentanucleotide repeats directly correlated with the extent of transcriptional activation by p53. It has been suggested that the microsatellite polymorphism may be associated with differential susceptibility to cancer. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.
quinone oxidoreductase PIG3
, tumor protein p53 inducible protein 3
, quinone oxidoreductase PIG3-like
, p53-induced gene 3 protein
, quinone oxidoreductase homolog