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anti-Human Stratifin Antikörper:
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Chicken Polyclonal Stratifin Primary Antibody für WB - ABIN2477187
dAlbis, Chanoine, Janmot, Mira, Couteaux: Muscle-specific response to thyroid hormone of myosin isoform transitions during rat postnatal development. in European journal of biochemistry / FEBS 1990
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Dog (Canine) Polyclonal Stratifin Primary Antibody für IHC (p), ELISA - ABIN547584
Koh, Wei, Li, Huang, Doan, Scolyer, Cochran, Binder: Differential gene expression profiling of primary cutaneous melanoma and sentinel lymph node metastases. in Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc 2012
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Human Polyclonal Stratifin Primary Antibody für ICC, IHC (p) - ABIN3044182
Yang, Cheung, Peng, He, Wu, Xie, Jiang, Huang, Chen, Lin, Kung: Makorin-2 is a neurogenesis inhibitor downstream of phosphatidylinositol 3-kinase/Akt (PI3K/Akt) signal. in The Journal of biological chemistry 2008
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Human Polyclonal Stratifin Primary Antibody für IHC (p), IHC - ABIN250903
Lodygin, Hermeking: The role of epigenetic inactivation of 14-3-3sigma in human cancer. in Cell research 2005
Cow (Bovine) Polyclonal Stratifin Primary Antibody für IHC, WB - ABIN2785886
Lu, Zhu, Wen, Yang, Shaw, Lammer, Finnell: Nicotinamide N-methyl transferase (NNMT) gene polymorphisms and risk for spina bifida. in Birth defects research. Part A, Clinical and molecular teratology 2008
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Human Monoclonal Stratifin Primary Antibody für IHC (p), IP - ABIN561091
Sousa, Zub, Aas, Hanssen-Bauer, Demirovic, Sarno, Tian, Liabakk, Slupphaug: An inverse switch in DNA base excision and strand break repair contributes to melphalan resistance in multiple myeloma cells. in PLoS ONE 2013
Study shows that 14-3-3 protein sigma isoform co-localizes with phosphorylated alpha-synuclein in Lewy bodies and Lewy neurites in patients with Lewy body disease.
SFN enhances RTK stabilization through abnormal USP8 regulation in lung adenocarcinoma
we found that differential expression of BAK1, FIS1, and SFN were altered across the Barrett's disease sequence and manipulation of these genes elicited significant effects on mitochondrial membrane potential.
silencing filamin A may inhibit the invasion and migration of breast cancer cells by upregulating 14-3-3sigma.
Over-expressed and hypo-methylated SFN gene is associated with hepatocellular carcinoma.
Review/Meta-analysis: 14-3-3 sigma promoter methylation may be associated with the carcinogenesis of breast cancer and might represent a useful blood-based biomarker for the clinical diagnosis of breast cancer.
14-3-3sigma has a paracrine effect in educating stromal cells in tumor-associated microenvironment.
This data indicates that 14-3-3sigma contributes to P-gp overexpression through interaction with PXR with rifampin and paclitaxel treatment.
The impact of AKT1 on glucocorticoid receptor (GR)-induced transcriptional activity in cooperation with phospho-serine/threonine-binding protein 14-3-3, was examined.
Data showed that 14-3-3s contributed to ionizing radiation (IR) resistance possibly by regulating cell cycle progression and non-homologous end joining repair of IR-induced DNA double strand breaks via regulating the expression of Chk2 and PARP1. These findings suggest that 14-3-3s may be an upstream master regulator in chemo and radiation resistance and cancer cell survival.
Structural basis for the interaction of a human HSPB6 protein with the 14-3-3 universal signaling regulator has been reported.
Dual co-expression of human fetal Tau with PKA in Escherichia coli results in multisite Tau phosphorylation including also naturally occurring sites which were not previously considered in the context of 14-3-3 binding. Tau protein co-expressed with PKA displays tight functional interaction with 14-3-3 isoforms of a different type.
Data suggest that 14-3-3 sigma protein exhibits two individual secondary binding sites for peptide fragments of TAZ protein; these two pockets appear to be part of at least three physiologically relevant and structurally characterized 14-3-3 protein-protein interaction interfaces.
These results suggest that SFN facilitates lung tumor development and progression. SFN appears to be a novel oncogene with potential as a therapeutic target
SFN regulates cancer metabolic reprogramming. It opposes tumor-promoting metabolic programs by enhancing c-Myc poly-ubiquitination and degradation. SFN suppresses cancer glycolysis, glutaminolysis, and mitochondrial biogenesis.
Data show that overexpression of the 14-3-3sigma isoform resulted in a disruption of the tubulin cytoskeleton mediated by binding Tau protein.
K17 expression is accompanied by cytoplasmic expression of 14-3-3 sigma, indicative of their functional relationship in oral squamous cell carcinoma
SFN affects the water-holding capacity, barrier function and dermal matrix components in photoaging skin. An increase of SFN triggered by UVB irradiation may be one of the causes of alterations observed in photoaging skin.
Results suggest a role of Wig-1 as a survival factor that directs the p53 stress response toward cell cycle arrest rather than apoptosis through the regulation of FAS and 14-3-3sigma mRNA levels.
14-3-3sigma alone or combined with HSP70 are potential prognostic biomarkers for HCC
Loss of 14-3-3-sigma sensitizes mice to chemically-induced skin carcinogenesis. Therefore, 14-3-3-sigma may indeed represent a mediator of tumor suppression in the skin.
14-3-3sigma stabilizes a complex of soluble actin and intermediate filament to enable breast tumor invasion.
these data provides the first evidence that 14-3-3 sigma is a Smad3-dependent target gene of TGF-beta1.
14-3-3sigma plays an important role in regulating mouse embryonic stem cell proliferation by binding and sequestering phosphorylated GSK-3beta and enhancing Wnt-signaled GSK-3beta inactivation.
We show that mice heterozygous for the 14-3-3sigma mutation have severe defects in hair shaft differentiation, resulting in destruction of the hair shaft during morphogenesis.
study shows that p63 and 14-3-3sigma play opposing roles in the development of skin tumors and that the accumulation of p63 is essential for Ras/14-3-3sigma mutation-induced papilloma formation and squamous cell carcinoma carcinogenesis
Data show that endogenous 14-3-3sigma protein formed a complex with FOXO1 protein.
14-3-3 sigma is required for TGF-beta1-mediated growth inhibition in mouse mammary epithelial cells.
14-3-3 sigma is needed for normal hair growth
14-3-3sigma plays a critical role in retaining epithelial polarity
14-3-3sigma is critical for regulating corneal epithelial proliferation and differentiation by regulating Notch signaling activity.
14-3-3 can mediate the relocalization of nuclear ligands by several mechanisms that ensure complete sequestration of the bound 14-3-3 complex in the cytoplasm.
Efp targets 14-3-3 sigma for proteolysis and promotes breast tumour growth.
Keratin 10 -/- mice exhibited induction of c-Myc, cyclin D1, 14-3-3sigma and wound healing keratins K6 and K16.
14-3-3 sigma appears to have a positive feedback effect on p53 activity
P4 regulates the phosphorylation status of 14-3-3sigma through a PKG-dependent pathway, and 14-3-3sigma plays a central and essential role in maintaining the viability of spontaneously immortalized granulosa cell.
mutation in stratifin is responsible for the repeated epilation phenotype
14-3-3sigma is a crucial regulator for skin proliferation and differentiation. A single nucleotide insertion in the Sfn coding region results in a truncated protein linked with phenotypes of Er-heterozygous and -homozygous mice.
14-3-3sigma stabilizes p27 Kip1 by inhibiting the activity of PKB/Akt
IKKalpha protects the 14-3-3sigma locus from hypermethylation, which serves as a mechanism of maintaining genomic stability in keratinocytes.
Adapter protein implicated in the regulation of a large spectrum of both general and specialized signaling pathways. Binds to a large number of partners, usually by recognition of a phosphoserine or phosphothreonine motif. Binding generally results in the modulation of the activity of the binding partner. When bound to KRT17, regulates protein synthesis and epithelial cell growth by stimulating Akt/mTOR pathway.
, 14-3-3 protein sigma
, epithelial cell marker protein 1
, 14-3-3 sigma protein
, tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, sigma polypeptide