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After genotoxic stress, Aspp1 promotes hematopoietic stem cell (HSC (zeige FUT1 Proteine)) cycling and induces p53 (zeige TP53 Proteine)-dependent apoptosis in cells with persistent DNA damage foci. Aspp1 also attenuates HSC (zeige FUT1 Proteine) self-renewal and accumulation of DNA damage in p53 (zeige TP53 Proteine) null HSCs.
Our study demonstrates a novel role for ASPP1 and ASPP2 (zeige TP53BP2 Proteine) in the death of retinal ganglion cells.
Aspp1 plays a crucial role in the initial assembly and function of lymphatic vessels during mouse development in a p53 (zeige TP53 Proteine)-independent manner.
results provide new insights into EGR-1 (zeige EGR1 Proteine)/ASPP1 regulatory loop in sensitizing Quercetin-induced apoptosis. EGR-1 (zeige EGR1 Proteine)/ASPP1, therefore, may be potentially used as therapeutic targets to improve cancer's response to pro-apoptosis treatments.
Results showed that the protein expression levels of ASPP1 in esophageal squamous cell carcinoma (ESCC) tissues and in paired noncancerous tissues were similar but was significantly associated with histological differentiation and invasive depth which suggest that it might be involved in the progression of ESCC.
Increased expression of p53 (zeige TP53 Proteine) and ASPP1 and downregulation of iASPP (zeige PPP1R13L Proteine).
ASPP1/2-PP1 complexes are required for chromosome segregation and kinetochore-microtubule attachments.
ASPP1/2 interacted with centrosome linker protein C-Nap1. Co-depletion of ASPP1 and ASPP2 inhibited re-association of C-Nap1 with centrosome at the end of mitosis.
ASPP1 and ASPP2 (zeige TP53BP2 Proteine) cooperate with oncogenic RAS to enhance the transcription and apoptotic function of p53 (zeige TP53 Proteine).
When the Px(T)PxR (zeige NR1I2 Proteine) motif is deleted or mutated via insertion of a phosphorylation site mimic (T311D), PP-1c fails to bind to all three ASPP proteins, ASPP1, ASPP2 (zeige TP53BP2 Proteine) and iASPP (zeige PPP1R13L Proteine).
the mRNA expression of ASPP1 and ASPP2 (zeige TP53BP2 Proteine) was frequently dowregulated in tumor tissues, and this decreased significantly in samples expressing wild-type p53 (zeige TP53 Proteine)
ASPP1 promoter methylation may be associated with the malignant progression of non-small cell lung cancer, and ASPP1 expression promotes cellular apoptosis.
The ability of ASPP1 to activate YAP (zeige YAP1 Proteine) results in the decreased expression of LATS2, which lowers the ability of p53 (zeige TP53 Proteine) to induce p21 (zeige CDKN1A Proteine), cell-cycle arrest and senescence.
This gene encodes a member of the ASPP (apoptosis-stimulating protein of p53) family of p53 interacting proteins. The protein contains four ankyrin repeats and an SH3 domain involved in protein-protein interactions. ASPP proteins are required for the induction of apoptosis by p53-family proteins. They promote DNA binding and transactivation of p53-family proteins on the promoters of proapoptotic genes. Expression of this gene is regulated by the E2F transcription factor.
protein phosphatase type 2C alpha 1
, protein phosphatase 1, regulatory (inhibitor) subunit 13B
, apoptosis-stimulating protein of p53, 1
, apoptosis-stimulating of p53 protein 1-like
, apoptosis-stimulating of p53 protein 1
, protein phosphatase 1 regulatory subunit 13B
, transformation related protein 53 binding protein 2
, tumor protein p53 binding protein, 2
, tumor protein p53-binding protein, 2
, apoptosis-stimulating protein of p53