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Human Polyclonal PPM1D Primary Antibody für WB - ABIN392853
Song, Han, Sabapathy, Lee, Yu, Choi: Expression of a homeostatic regulator, Wip1 (wild-type p53-induced phosphatase), is temporally induced by c-Jun and p53 in response to UV irradiation. in The Journal of biological chemistry 2010
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Human Polyclonal PPM1D Primary Antibody für IP, WB - ABIN151547
Lee, Lee, Moon, Shim, Fornace, Cha: Senescent growth arrest in mesenchymal stem cells is bypassed by Wip1-mediated downregulation of intrinsic stress signaling pathways. in Stem cells (Dayton, Ohio) 2009
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Human Polyclonal PPM1D Primary Antibody für IF (p), IHC (p) - ABIN740415
Wang, Cui, Wen, Guo, Zhang, Chen: Cisplatin induces HepG2 cell cycle arrest through targeting specific long noncoding RNAs and the p53 signaling pathway. in Oncology letters 2017
Wip1 modulates macrophage migration and phagocytosis via Rac1-GTPase (zeige RACGAP1 Antikörper) and PI3K/AKT (zeige AKT1 Antikörper) signalling pathways.
The results suggest that Wip1 could protect the heart from MI-induced ischemic injury.
These data collectively indicate that Wip1 modulates host sensitivity to colitis by intrinsically regulating immune cells.
Wip1 phosphatase plays a vital role in regulating hippocampal synaptic plasticity by modulating the phosphorylation of CaMKII (zeige CAMK2G Antikörper).
Findings indicate that the PPM1D-Ulk1 (zeige ULK1 Antikörper) axis plays a pivotal role in genotoxic stress-induced autophagy.
This suggests an important cross-talk between SHH and WIP1 pathways that accelerates tumorigenesis and supports WIP1 inhibition as a potential treatment strategy for MB.
WIP1 phosphatase plays a pro-adipogenic role by interacting directly with PPARgamma (zeige PPARG Antikörper) and dephosphorylating p-PPARgamma (zeige PPARG Antikörper) S112 in vitro and in vivo.
this study shows that knock out of Wip1 in mouse aggravates colonic inflammation and increases neutrophils migration
the data indicate that the WIP1 phosphatase functions to maintain insulin (zeige INS Antikörper) sensitivity and glucose homeostasis.
Study suggests a potential protective function of p53 (zeige TP53 Antikörper)-induced phosphatase 1 in mood stabilization.
ese results enhance our understanding of the molecular mechanisms that govern nucleoli formation by demonstrating that PPM1D regulates nucleolar formation by regulating NPM (zeige NPM1 Antikörper) phosphorylation status through a novel signalling pathway, PPM1D-CDC25C (zeige CDC25C Antikörper)-CDK1 (zeige CDK1 Antikörper)-PLK1 (zeige PLK1 Antikörper)
These data support the notion that Wip1 contributes to the formation of the ERMs in PDR membranes via NF-kappaB (zeige NFKB1 Antikörper) signaling.
In an in vitro model of the blood-brain barrier, LPS (zeige IRF6 Antikörper) raised Wip1 expression. Wip1 knockdown increased permeability and decreased transepithelial electrical resistance, protein expression of ZO-1 (zeige TJP1 Antikörper), and occluding. Wip1 silencing augmented TNF-alpha (zeige TNF Antikörper), IL-1beta (zeige IL1B Antikörper), IL-12 (zeige IL12A Antikörper), and IL-6 (zeige IL6 Antikörper). Sonic hedgehog (zeige SHH Antikörper) signaling was activated by Wip1 overexpression and inhibited by silencing. Wip1 may protect the BBB (zeige ALMS1 Antikörper) against LPS (zeige IRF6 Antikörper) damage via SHH (zeige SHH Antikörper) signal...
Studies suugest Wip1 role in tumorigenesis through regulation of p53 (zeige TP53 Antikörper) and p38MAPK (zeige MAPK14 Antikörper) pathways.
The inhibition of Wip1 might fortify p53 (zeige TP53 Antikörper)-mediated tumor suppression by Mdm2 (zeige MDM2 Antikörper) antagonists.
Wip1 suppressed ovarian cancer cell invasion, migration, epithelial to mesenchymal transition (EMT (zeige ITK Antikörper)), and ovarian cancer metastasis in xenograft animal models.
model reproduces the observed cellular phenotypes in experiments: oscillatory (for low DNA damage) regulated by negative feedback loops involving mainly p53 (zeige TP53 Antikörper) and Mdm2 (zeige MDM2 Antikörper) and apoptotic or senescent (for high DNA damage) regulated by the positive p53 (zeige TP53 Antikörper)/Wip1/miR-16 (zeige GDE1 Antikörper) feedback loop
Wip1 activity and its relevance to cancer as an oncoprotein is reviewed
The authors show that a global spread of ATM (zeige ATM Antikörper) activity on chromatin and phosphorylation of ATM (zeige ATM Antikörper) targets including KAP1 (zeige CDKN3 Antikörper) control Plk1 (zeige PLK1 Antikörper) re-activation. These phosphorylations are rapidly counteracted by the chromatin-bound phosphatase Wip1, allowing cell cycle restart despite persistent ATM (zeige ATM Antikörper) activity present at DNA lesions.
The protein encoded by this gene is a member of the PP2C family of Ser/Thr protein phosphatases. PP2C family members are known to be negative regulators of cell stress response pathways. The expression of this gene is induced in a p53-dependent manner in response to various environmental stresses. While being induced by tumor suppressor protein TP53/p53, this phosphatase negatively regulates the activity of p38 MAP kinase, MAPK/p38, through which it reduces the phosphorylation of p53, and in turn suppresses p53-mediated transcription and apoptosis. This phosphatase thus mediates a feedback regulation of p38-p53 signaling that contributes to growth inhibition and the suppression of stress induced apoptosis. This gene is located in a chromosomal region known to be amplified in breast cancer. The amplification of this gene has been detected in both breast cancer cell line and primary breast tumors, which suggests a role of this gene in cancer development.
, p53-induced protein phosphatase 1
, protein phosphatase 1D
, protein phosphatase 2C isoform delta
, protein phosphatase magnesium-dependent 1 delta
, protein phosphatase 1D magnesium-dependent, delta isoform
, protein phosphatase 2C delta isoform
, protein phosphatase Wip1
, wild-type p53-induced phosphatase 1