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Our study highlights the underlying mechanism of cross interaction between ASCs and breast cancer cells, and indicates that PAG1/Cbp in breast cancer cell may modulate tumor progression and acquired chemoresistance in the ASCs-associated breast cancer microenvironment through Src (zeige SRC Proteine) and AKT (zeige AKT1 Proteine)/mTOR (zeige FRAP1 Proteine) pathways.
Up-regulated expression of CBP (zeige CREBBP Proteine) in Jurkat cells could reduce cell homogeneity and promote cell apoptosis
No association Pag1 mutation with patient with Schizophrenia.
The risk-associated allele of rs2370615 predisposes to allergic disease by increasing PAG1 expression, which might promote B cell activation (zeige BLNK Proteine) and have a pro-inflammatory effect.
CBP (zeige CREBBP Proteine) may decrease the metastasis of esophageal carcinoma by inhibiting the activation of Src (zeige SRC Proteine).
The inhibitory function of novobiocin in disrupting the HIF1alpha (zeige HIF1A Proteine)/p300 (zeige EP300 Proteine) complex might be important in tumor cell growth.
siRNA directed against PAG1 in a radioresistant (Hep-2max) cell line dramatically enhanced the radiosensitivity and IR-induced cell death.
expression of CBP (zeige CREBBP Proteine) gene is decreased in esophageal carcinoma, which might contribute to the tumorigenesis and progression.
An over-expression of PAG1 in PC-3M-1E8 cells effectively suppresses the activation of Ras and ERK (zeige EPHB2 Proteine), as well as the cyclin D1 (zeige CCND1 Proteine) expression, leading to an inhibition of the proliferation ability of tumor cells.
Cbp (zeige CREBBP Proteine) down-regulation is primarily mediated by epigenetic histone modifications via oncogenic MAPK (zeige MAPK1 Proteine)/PI3K (zeige PIK3CA Proteine) pathways in a subset of cancer cells.
Inducible knockdown of PAPP-A (zeige PAPPA Proteine) gene expression in adult female mice extends life span.
Intrinsic mitochondrial oxidative capacity was significantly increased in skeletal muscle of aged PAPP-A (zeige PAPPA Proteine) KO compared to WT mice. Moreover, 18-month-old PAPP-A (zeige PAPPA Proteine) KO mice exhibited significantly enhanced endurance running on a treadmill. Thus, PAPP-A (zeige PAPPA Proteine) deficiency in mice is associated with indices of healthy skeletal muscle function with age.
our findings illustrate that Cbp (zeige CREBBP Proteine) is an important regulator of Csk (zeige CSK Proteine) recruitment to the SFK Lyn (zeige LYN Proteine) in Eporesponsive erythroid cells.
Snell, GHKRO, and PAPPA (zeige PAPPA Proteine)-KO mice express high levels of two proteins involved in DNA repair, O-6-methylguanine-DNA methyltransferase (MGMT (zeige MGMT Proteine)) and N-myc downstream-regulated gene 1 (NDRG1 (zeige NDRG1 Proteine)).
STC2 (zeige STC2 Proteine) is involved in regulating PAPP-A (zeige PAPPA Proteine) activity during the development of atherosclerosis
Study demonstrates proof-of-principle and provides feasibility for a novel therapeutic strategy to inhibit atherosclerotic plaque burden by selective targeting of PAPP-A (zeige PAPPA Proteine).
stimulation of PAPP-A (zeige PAPPA Proteine) expression by intermittent PTH (zeige PTH Proteine) treatment contributes to PTH (zeige PTH Proteine) bone anabolism in mice
PAPP-A (zeige PAPPA Proteine) affects fascicle structure, thereby affecting tendon phenotype.
This study demonstrated that cbp (zeige CREBBP Proteine) increase in skeletal muscle in muscle atrophy.
PAG is constitutively phosphorylated in resting T cells and rapidly dephosphorylated once the TCR is engaged.
The protein encoded by this gene is a type III transmembrane adaptor protein that binds to the tyrosine kinase csk protein. It is thought to be involved in the regulation of T cell activation.
phosphoprotein associated with glycosphingolipid microdomains 1
, phosphoprotein associated with glycosphingolipid-enriched microdomains 1-like
, Csk-binding protein
, phosphoprotein associated with glycosphingolipid-enriched microdomains 1
, transmembrane adapter protein PAG
, transmembrane adaptor protein PAG
, transmembrane phosphoprotein Cbp
, Csk binding protein
, csk-binding protein
, phosphoprotein transmembrane adaptor 1
, phosphoprotein-associated with GEMs
, IGF-dependent IGFBP-4 protease
, insulin-like growth factor-dependent IGF-binding protein 4 protease