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Human p300 Protein expressed in Insect cells (Sf9) - ABIN2720219
Martinez, Abe, Hong, Molyneux, Yarnell, Löhr, Driever, Acosta, Arcos-Burgos, Muenke: An Ultraconserved Brain-Specific Enhancer Within ADGRL3 (LPHN3) Underpins Attention-Deficit/Hyperactivity Disorder Susceptibility. in Biological psychiatry 2016
E-cadherin (zeige CDH1 Proteine) expression was increased by transfection of p300 small interfering RNA in a dose-dependent manner.. There was a correlation between Snail (zeige SNAI1 Proteine) and p300 expressions in lung cancer. Moreover, p300 acetylates Snail (zeige SNAI1 Proteine) both in vivo and in vitro, and K187 may be involved in this modification.
Two possible modes of pioneering associated with combinations of H2A.Z (zeige H2AFZ Proteine) and p300/CBP (zeige CREBBP Proteine) at nucleosome-occupied enhancers.
these results demonstrate that the reversible acetylation of FOXM1 (zeige FOXM1 Proteine) by p300/CBP (zeige CREBBP Proteine) and SIRT1 (zeige SIRT1 Proteine) modulates its transactivation function
Ectopic expression of EP300-ZNF384 (zeige ZNF384 Proteine) and CREBBP (zeige CREBBP Proteine)-ZNF384 (zeige ZNF384 Proteine) fusion altered differentiation of mouse hematopoietic stem and progenitor cells and also potentiated oncogenic transformation in vitro.our results indicate that gene fusion is a common class of genomic abnormalities in childhood ALL and that recurrent translocations involving EP300 and CREBBP (zeige CREBBP Proteine) may cause epigenetic deregulation with potential for therapeutic targeting.
p300 inhibition attenuates both thrombin (zeige F2 Proteine) induced-CCL2 (zeige CCL2 Proteine) expression and histone H3 (zeige HIST3H3 Proteine) and H4 acetylation in HLFs, suggesting that p300 is involved in thrombin (zeige F2 Proteine)-induced CCL2 (zeige CCL2 Proteine) expression via hyperacetylating histone H3 (zeige HIST3H3 Proteine) and H4.
p300-dependent histone H3 (zeige HIST3H3 Proteine) acetylation and C/EBPbeta (zeige CEBPB Proteine)-regulated IKKbeta (zeige IKBKB Proteine) expression contribute to thrombin (zeige F2 Proteine)-induced IL-8/CXCL8 (zeige IL8 Proteine) expression in human lung epithelial cells.
MnTE-2-PyP (zeige PPA1 Proteine) decreased p300 complex binding to a specific HRE motif within the PAI-1 (zeige SERPINE1 Proteine) gene promoter region, suppressed H3K9 acetylation, and consequently, repressed PAI-1 (zeige SERPINE1 Proteine) expression. Mechanistically, less p300 transcriptional complex binding is not due to the reduction of binding between p300 and HIF-1 (zeige HIF1A Proteine)/CREB (zeige CREB1 Proteine) transcription factors, but through inhibiting the binding of HIF-1 (zeige HIF1A Proteine)/CREB (zeige CREB1 Proteine) transcription factors to DNA
High p300 expression is associated with prostate cancer growth.
Understanding the effects of disrupting the acetyltransferase activity of CBP/p300 (zeige CREBBP Proteine) could pave the way for new therapeutic approaches to treat patients with these diseases
How cancer cells use p300/CBP (zeige CREBBP Proteine) in their favor varies depending on the cellular context and is evident by the growing list of loss- and gain-of-function genetic alterations in p300 and CBP (zeige CREBBP Proteine) in solid tumors and hematological malignancies.[review]
Here the authors report a lipopolysaccharide-induced NFkappaB enhanceosome in which TonEBP (zeige NFAT5 Proteine) is required for the recruitment of p300 (zeige NOTCH1 Proteine). Increased expression of TonEBP (zeige NFAT5 Proteine) enhances the NFkappaB activity and reduced TonEBP (zeige NFAT5 Proteine) expression lowers it.
Enhancer-priming by MLL3/MLL4 followed by enhancer-activation by CBP/p300 (zeige CREBBP Proteine) sequentially shape dynamic enhancer landscapes during cell differentiation
Data show that LPS (zeige TLR4 Proteine) induces endoplasmic reticulum (ER) stress and P300 (zeige NOTCH1 Proteine) activity via the XBP1 (zeige XBP1 Proteine)/IRE1 (zeige ERN1 Proteine) pathway.
Loss of p300 (zeige NOTCH1 Proteine) expression is associated with leukemogenesis.
UTX (zeige KDM6A Proteine)-MLL4-p300 (zeige NOTCH1 Proteine) transcriptional regulatory network establishing an "active enhancer landscape" and defines a detailed mechanism for the joint deposition of H3K4me1 and H3K27ac.
Acetylation-dependent control of global poly(A) RNA degradation by CBP/p300 (zeige CREBBP Proteine) and HDAC1-HDAC2 (zeige HDAC1 Proteine) has been described.
Data, including data from studies in cells from knockout mice, suggest that Prmt1 (zeige PRMT1 Proteine) activity was necessary for c-Myc (zeige MYC Proteine) binding to acetyltransferase p300 (zeige NOTCH1 Proteine) in myeloid cells; Prmt1 (zeige PRMT1 Proteine) inhibition decreases p300 (zeige NOTCH1 Proteine) recruitment to c-Myc (zeige MYC Proteine) target promoters and increased Hdac1 (zeige HDAC1 Proteine) recruitment. [Prmt1 (zeige PRMT1 Proteine), protein arginine N-methyltransferase 1 (zeige PRMT1 Proteine); c-Myc (zeige MYC Proteine) = Proto-Oncogene (zeige RAB1A Proteine) Proteins c-myc (zeige MYC Proteine); Hdac1 (zeige HDAC1 Proteine) = histone deacetylase 1 (zeige HDAC1 Proteine)]
In line with the acetyltransferase activity of p300 (zeige NOTCH1 Proteine), H3K27 acetylation was reduced after HDACi and resulted in the formation of heterochromatin in the PTGES1 gene. In conclusion, HDAC (zeige HDAC3 Proteine) activity maintains PTGES1 expression by recruiting p300 (zeige NOTCH1 Proteine) to its gene
ARX positively regulates Wnt (zeige WNT2 Proteine)/ beta-catenin (zeige CTNNB1 Proteine) signaling and the C-terminal domain of ARX interacts with the armadillo (zeige PKP1 Proteine) repeats in beta-catenin (zeige CTNNB1 Proteine) to promote Wnt (zeige WNT2 Proteine)/beta-catenin (zeige CTNNB1 Proteine) signaling. In addition, we found BCL9 (zeige BCL9 Proteine) and P300 (zeige NOTCH1 Proteine) also interact with ARX to modulate Wnt (zeige WNT2 Proteine)/beta-catenin (zeige CTNNB1 Proteine) signaling.
2-O, 3-O desulfated heparin inhibited HMGB1 (zeige HMGB1 Proteine) release, at least in part, by direct molecular inhibition of p300 HAT activity.
This gene encodes the adenovirus E1A-associated cellular p300 transcriptional co-activator protein. It functions as histone acetyltransferase that regulates transcription via chromatin remodeling and is important in the processes of cell proliferation and differentiation. It mediates cAMP-gene regulation by binding specifically to phosphorylated CREB protein. This gene has also been identified as a co-activator of HIF1A (hypoxia-inducible factor 1 alpha), and thus plays a role in the stimulation of hypoxia-induced genes such as VEGF. Defects in this gene are a cause of Rubinstein-Taybi syndrome and may also play a role in epithelial cancer.
histone acetyltransferase p300
, histone acetyltransferase
, E1A binding protein p300
, histone acetyltransferase p300-like
, E1A-associated protein p300
, E1A-binding protein, 300kD
, p300 HAT