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Human p300 Protein expressed in Insect cells (Sf9) - ABIN2720219
Martinez, Abe, Hong, Molyneux, Yarnell, Löhr, Driever, Acosta, Arcos-Burgos, Muenke: An Ultraconserved Brain-Specific Enhancer Within ADGRL3 (LPHN3) Underpins Attention-Deficit/Hyperactivity Disorder Susceptibility. in Biological psychiatry 2016
Data generated with primary human hepatic stellate cells (HSC) supports that stiffness-mediated HSC activation requires p300.
The histone acylation activity of p300 can be activated by pre-existing lysine crotonylation through a positive feedback mechanism.
epigenomic profiling of clear cell renal cell carcinoma (zeige MOK Proteine) (ccRCC) establishes a compendium of somatically altered cis (zeige CISH Proteine)-regulatory elements, uncovering new potential targets including ZNF395 (zeige ZNF395 Proteine). Loss of VHL (zeige VHL Proteine), a ccRCC signature event, causes pervasive enhancer malfunction, with binding of enhancer-centric HIF2a (zeige EPAS1 Proteine) and recruitment of histone acetyltransferase p300 at preexisting lineage-specific promoter-enhancer complexes
Histone acetyltransferase EP300 is necessary for the transcription factor SOX2 (zeige SOX2 Proteine) activity in basal cells, including for induction of the squamous fate. EP300 copy number gains are common in squamous cell carcinoma SQCCs, including lung cancer SQCC cell lines.
High expression of EP300 is associated with colorectal cancer.
Transcriptional coactivator p300 gene polymorphism correlates with the development and advancement of diabetic kidney disease. Additionally, the SIRT1 (zeige SIRT1 Proteine) gene collaborates with the p300 gene and participates in promoting albuminuria in type 2 diabetes mellitus patients.
These results reveal a novel RTK-AKT (zeige AKT1 Proteine)-p300-ADA3 (zeige TADA3 Proteine) signaling pathway involved in growth factor-induced cell cycle progression.
Study suggest that both p300 and CREB (zeige CREB1 Proteine) are required for the function integrity of HIF-1alpha (zeige HIF1A Proteine) transcription machinery and subsequent angiogenesis, suggesting future studies to improve burn wound healing might be directed to optimization of the interaction between p300, CREB (zeige CREB1 Proteine) and HIF-1alpha (zeige HIF1A Proteine).
These results suggest that EP300 harbors adaptive variants in Tibetans, which might contribute to high-altitude adaptation through regulating NO production.
EP300 plays a major role in the reprogramming events, leading to a more malignant phenotype with the acquisition of drug resistance and cell plasticity, a characteristic of metaplastic breast cancer.
Study in mouse model found that liver stiffness activates hepatic stellate cells differentiation into myofibroblasts, which required nuclear accumulation of p300 (zeige NOTCH1 Proteine).
Data (including data from studies in knockout and transgenic mice) suggest that Ep300 and Crebbp (zeige CREBBP Proteine) are limiting cofactors for pancreatic islet development (including gene expression regulation and cell proliferation), and hence for postnatal glucose homeostasis, with some functional redundancy. (Ep300 = E1A binding protein p300; Crebbp (zeige CREBBP Proteine) = CREB binding protein (zeige CREBBP Proteine))
Here the authors report a lipopolysaccharide-induced NFkappaB enhanceosome in which TonEBP (zeige NFAT5 Proteine) is required for the recruitment of p300 (zeige NOTCH1 Proteine). Increased expression of TonEBP (zeige NFAT5 Proteine) enhances the NFkappaB activity and reduced TonEBP (zeige NFAT5 Proteine) expression lowers it.
Enhancer-priming by MLL3/MLL4 followed by enhancer-activation by CBP/p300 (zeige CREBBP Proteine) sequentially shape dynamic enhancer landscapes during cell differentiation
Data show that LPS (zeige TLR4 Proteine) induces endoplasmic reticulum (ER) stress and P300 (zeige NOTCH1 Proteine) activity via the XBP1 (zeige XBP1 Proteine)/IRE1 (zeige ERN1 Proteine) pathway.
Loss of p300 (zeige NOTCH1 Proteine) expression is associated with leukemogenesis.
UTX (zeige KDM6A Proteine)-MLL4-p300 (zeige NOTCH1 Proteine) transcriptional regulatory network establishing an "active enhancer landscape" and defines a detailed mechanism for the joint deposition of H3K4me1 and H3K27ac.
Acetylation-dependent control of global poly(A) RNA degradation by CBP/p300 (zeige CREBBP Proteine) and HDAC1-HDAC2 (zeige HDAC1 Proteine) has been described.
Data, including data from studies in cells from knockout mice, suggest that Prmt1 (zeige PRMT1 Proteine) activity was necessary for c-Myc (zeige MYC Proteine) binding to acetyltransferase p300 (zeige NOTCH1 Proteine) in myeloid cells; Prmt1 (zeige PRMT1 Proteine) inhibition decreases p300 (zeige NOTCH1 Proteine) recruitment to c-Myc (zeige MYC Proteine) target promoters and increased Hdac1 (zeige HDAC1 Proteine) recruitment. [Prmt1 (zeige PRMT1 Proteine), protein arginine N-methyltransferase 1 (zeige PRMT1 Proteine); c-Myc (zeige MYC Proteine) = Proto-Oncogene (zeige RAB1A Proteine) Proteins c-myc (zeige MYC Proteine); Hdac1 (zeige HDAC1 Proteine) = histone deacetylase 1 (zeige HDAC1 Proteine)]
In line with the acetyltransferase activity of p300 (zeige NOTCH1 Proteine), H3K27 acetylation was reduced after HDACi and resulted in the formation of heterochromatin in the PTGES1 gene. In conclusion, HDAC (zeige HDAC3 Proteine) activity maintains PTGES1 expression by recruiting p300 (zeige NOTCH1 Proteine) to its gene
This gene encodes the adenovirus E1A-associated cellular p300 transcriptional co-activator protein. It functions as histone acetyltransferase that regulates transcription via chromatin remodeling and is important in the processes of cell proliferation and differentiation. It mediates cAMP-gene regulation by binding specifically to phosphorylated CREB protein. This gene has also been identified as a co-activator of HIF1A (hypoxia-inducible factor 1 alpha), and thus plays a role in the stimulation of hypoxia-induced genes such as VEGF. Defects in this gene are a cause of Rubinstein-Taybi syndrome and may also play a role in epithelial cancer.
histone acetyltransferase p300
, histone acetyltransferase
, E1A binding protein p300
, histone acetyltransferase p300-like
, E1A-associated protein p300
, E1A-binding protein, 300kD
, p300 HAT