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Human FAS Protein expressed in Synthetic - ABIN2691045
Liles, Kiener, Ledbetter, Aruffo, Klebanoff: Differential expression of Fas (CD95) and Fas ligand on normal human phagocytes: implications for the regulation of apoptosis in neutrophils. in The Journal of experimental medicine 1996
Show all 6 Pubmed References
Human FAS Protein expressed in Insect Cells - ABIN967460
Cheng, Zhou, Liu, Shapiro, Brauer, Kiefer, Barr, Mountz: Protection from Fas-mediated apoptosis by a soluble form of the Fas molecule. in Science (New York, N.Y.) 1994
Show all 3 Pubmed References
In primary hyperparathyroidism, hyperplasias demonstrated the highest expression of TRAIL and Fas, whereas in adenomas it was increased compared to normal tissue, but lower than in hyperplasias.
Data suggest that Fas and TNFR1 (zeige TNFRSF1A Proteine) are involved in glaucoma mechanisms in cornea; pro-apoptotic effect of anti-glaucoma medication clonidine on corneal epithelial cells triggers Fas/TNFR1 (zeige TNFRSF1A Proteine)-mediated, mitochondria-dependent signaling pathway. (Fas = Fas cell surface death receptor ; TNFR1 (zeige TNFRSF1A Proteine) = TNF (zeige TNF Proteine) receptor superfamily member 1A)
These data suggested that YY1 (zeige YY1 Proteine) may be important for apoptosis induction via the regulation of Fas during sepsis. Therefore, Fas may be a potential therapeutic target to prevent MOD through regulation of YY1 (zeige YY1 Proteine) expression. Furthermore, YY1 (zeige YY1 Proteine) and Fas expression in PBMCs may be used to as prognostic markers.
Fas activation rapidly changes the interconversion of PC and PI, which then drives enhanced endocytosis, thus likely propagating death signaling from the cell surface to mitochondria and other organelles
using pifithrin alpha we observed a decrease in apoptosis induced by MG132, and by APO-1 plus MG132, suggesting that restoration of APO-1 sensitivity occurs in part through an increase in both the levels and the activity of p53 (zeige TP53 Proteine). The use of small molecules to inhibit the proteasome pathway might permit the activation of cell death, providing new opportunities for CC treatment.
Fas - 670A/G genotypes or alleles were not significantly different between controls and transplant recipients and among transplant recipients with and without acute rejection following pediatric renal transplantation
data suggest miR (zeige MLXIP Proteine)-374a is a negative regulator of Fas death receptor which is able to enhance the cell survival and protect retinal pigment epithelial cells against oxidative conditions.
CD3 (zeige CD3 Proteine)(+) CD8 (zeige CD8A Proteine)(+) NKG2D (zeige KLRK1 Proteine)(+) T Lymphocytes Induce Apoptosis and Necroptosis in HLA-Negative Cells via FasL (zeige FASL Proteine)-Fas Interaction
High-grade gliomas (HGG) showed significantly lower FAS but higher FAS ligand (FAS-L (zeige FASL Proteine)) expression than high-grade gliomas (HGG).
Peripheral CD95 expression higher than 30% could be used among the exclusion criteria in a multicomponent score for mycosis fungoides diagnosis.
Hrd1 (zeige SYVN1 Proteine)-null B cells exhibited high Fas expression during activation and rapidly underwent Fas-mediated apoptosis, which could be largely inhibited by FasL (zeige FASL Proteine) neutralization. Fas mutation in Hrd1 (zeige SYVN1 Proteine) KO mice abrogated the increase in B-cell AICD. We identified Hrd1 (zeige SYVN1 Proteine) as the first E3 ubiquitin ligase (zeige MUL1 Proteine) of the death receptor Fas and Hrd1 (zeige SYVN1 Proteine)-mediated Fas destruction as a molecular mechanism in regulating B-cell immunity.
FAS contributes to mitochondrial dysfunction, steatosis development, and insulin (zeige INS Proteine) resistance under high fat diet.
anti-apoptotic molecules BclxL (zeige BCL2L1 Proteine) and Bcl-2 (zeige BCL2 Proteine) and the pro-apoptotic factors BAD and BID (zeige BID Proteine) cooperate to promote migration of triple-negative breast cancer cells stimulated with cl-CD95L (zeige FASL Proteine).
These findings reveal a role for MOAP-1 (zeige MOAP1 Proteine) in Fas signaling in the liver by promoting MTCH2 (zeige MTCH2 Proteine)-mediated tBid recruitment to mitochondria.
The in vivo delivery of CRISPR/Cas9 could maintain liver homeostasis and protect hepatocytes from Fas-mediated cell apoptosis in the fulminant hepatic failure model.
This study demonstrated that Ischemic neurons release sFasL (zeige FASL Proteine), which contributes to M1-microglial polarization.
results indicate that IL-1beta (zeige IL1B Proteine), produced by the inflammasome and Fas-dependent mechanisms, contributes cooperatively to the Th17/Th1 (zeige HAND1 Proteine) induction during bacterial infection. This study provides a deeper understanding of the molecular mechanisms underlying Th17/Th1 (zeige HAND1 Proteine) induction during pathogenic microbial infections in vivo.
this study shows that CD95-mediated calcium signaling promotes Th17 cell trafficking to inflamed organs in lupus-prone mice
accelerating effects of Tlr9 (zeige TLR9 Proteine) deficiency
K8/K18 (zeige KRT18 Proteine)-dependent PKCdelta (zeige PKCd Proteine)- and ASMase (zeige SMPD1 Proteine)-mediated modulation of lipid raft size can explain the more prominent FasR-mediated signaling resulting from K8/K18 (zeige KRT18 Proteine) loss.
Messenger RNA and protein levels of prostaglandin (PG) E synthase (PGES (zeige PTGES Proteine)), PGF2alpha receptor (PGFR), tumor necrosis factor-alpha (TNF (zeige TNF Proteine)) and Fas were found to be higher in the corpus luteum of pregnancy than in corpus luteum of the cycle.
Results did not support that K8/K18 (zeige KRT18 Proteine) filaments influence the expression of Fas on the surface of luteal cells.
activation of the Fas pathway and presence of FSH (zeige BRD2 Proteine) during in vitro maturation increased the incidence of apoptosis in cumulus cells
demonstrated for the first time that normal ejaculated spermatozoa express Fas antigen (zeige FASL Proteine); data showed that a large percentage of normal ejaculated spermatozoa of fertile bulls are immunocytochemically positive for Fas
Fas was expressed on fetal pig pancreatic cells, both beta and non-beta cells, and the level of expression could be upregulated by exposure to interleukin 1beta
The expression of FAS and FAS ligand (zeige FASL Proteine) in splenic macrophages co-infected with porcine circovirus 2 and porcine reproductive and respiratory syndrome virus is reported
The present results may provide some insights to understand the role of Fas/FasL (zeige FASL Proteine) in the spinal cord but not motor cortex with neuronal apoptosis and neuroplasticity in monkeys subjected to hemisection spinal cord injury.
Ligustrazine has notable protective effects on pulmonary ischemia/reperfusion injury inhibiting Fas/FasL (zeige FASL Proteine) mRNA express in lung tissue and decreasing apoptosis.
The protein encoded by this gene is a member of the TNF-receptor superfamily. This receptor contains a death domain. It has been shown to play a central role in the physiological regulation of programmed cell death, and has been implicated in the pathogenesis of various malignancies and diseases of the immune system. The interaction of this receptor with its ligand allows the formation of a death-inducing signaling complex that includes Fas-associated death domain protein (FADD), caspase 8, and caspase 10. The autoproteolytic processing of the caspases in the complex triggers a downstream caspase cascade, and leads to apoptosis. This receptor has been also shown to activate NF-kappaB, MAPK3/ERK1, and MAPK8/JNK, and is found to be involved in transducing the proliferating signals in normal diploid fibroblast and T cells. Several alternatively spliced transcript variants have been described, some of which are candidates for nonsense-mediated mRNA decay (NMD). The isoforms lacking the transmembrane domain may negatively regulate the apoptosis mediated by the full length isoform.
APO-1 cell surface antigen
, CD95 antigen
, Delta Fas/APO-1/CD95
, FAS 827dupA
, FASLG receptor
, Fas (TNF receptor superfamily, member 6)
, Fas AMA
, TNF receptor superfamily member 6
, apoptosis antigen 1
, apoptosis-mediating surface antigen FAS
, tumor necrosis factor receptor superfamily member 6
, tumor necrosis factor receptor superfamily, member 6
, Fas antigen
, Fas (TNF receptor superfamily member)
, apo-1 antigen
, Fas antigen (ATP1)
, Fas receptor
, Tumor necrosis factor receptor superfamily, member 6
, apoptosis (APO-1) antigen 1 ( FAS ), member 6
, Fas receptor CD95