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Human E2F1 Protein expressed in HEK-293 Cells - ABIN2719894
Tarangelo, Lo, Teng, Kim, Le, Watson, Furth, Raman, Ehmer, Viatour: Recruitment of Pontin/Reptin by E2f1 amplifies E2f transcriptional response during cancer progression. in Nature communications 2015
specific alternate transcripts of activator E2F (zeige E2F2 Proteine), dE2F1, may have a dual function on cell cycle progression and cannot simply be viewed as a pro-proliferative transcription factor
These findings identify a key function of E2F in skeletal muscle required for animal viability, and illustrate how the cell cycle regulator is repurposed in post-mitotic cells.
Mechanistically, miR (zeige MYLIP Proteine)-998 operates by repressing dCbl, a negative regulator of EGFR (zeige EGFR Proteine) signaling. Significantly, dCbl is a critical target of miR (zeige MYLIP Proteine)-998 since dCbl phenocopies the effects of miR (zeige MYLIP Proteine)-998 on dE2f1-dependent apoptosis in rbf (zeige ATP5I Proteine) mutants
also demonstrated that an optimum level of dLin52 is needed for dE2F1/2 activity on the hid promoter
Results show that regulation of e2f1 and PCNA (zeige PCNA Proteine) by DREF (zeige ZBED1 Proteine) in vivo is complex and the regulation mechanism may differ with the tissue and/or positions in the tissue.
Loss of dE2F compromises mitochondrial function.
Data propose that the interaction between ORC5 (zeige ORC5 Proteine) and dE2F1 may reflect a feedback mechanism between replication initiation proteins and dE2F1 that ensures that proliferating cells maintain a robust level of replication proteins for the next cell cycle.
results suggest that E2F/DP complexes are essential for all genomic targeting of RBF1
Inappropriate accumulation of E2f1 protein during S phase triggers the elimination of potentially hyperplastic cells via apoptosis in order to ensure normal development of rapidly proliferating tissues.
endocycles of Drosophila are driven by a molecular oscillator in which the E2F1 transcription factor promotes CycE (zeige CCNE1 Proteine) expression and S-phase initiation, S-phase then activates the CRL4(CDT2) ubiquitin ligase, and this in turn mediates the destruction of E2F1
This study suggests for the first time an involvement of E2F1 copy number variations in testicular germ cell tumor susceptibility and supports previous preliminary data on the importance of AKT (zeige AKT1 Proteine)/mTOR (zeige FRAP1 Proteine) signaling pathway in this cancer.
High E2F1 expression is associated with gastric cancer.
Data suggest that the protein arginine methyltransferase 5 (PRMT5 (zeige PRMT5 Proteine))-E2F1 transcription factor (E2F-1) pathway may act as a common target for exogenous lectins including Anguilla japonica lectin 1 (AJL1), and the cellular response to exogenous AJL1 may suggest a novel agent for cancer gene therapy.
The low level E2F1 are sufficient to induce numerous cell cycle-promoting genes, intermediate levels induce growth arrest genes (i.e., p18 (zeige CDKN2C Proteine), p19 (zeige CDKN2D Proteine) and p27 (zeige PAK2 Proteine)), whereas higher levels are necessary to induce key apoptotic E2F1 targets APAF1 (zeige APAF1 Proteine), PUMA (zeige BBC3 Proteine), HRK and BIM (zeige BCL2L11 Proteine).
This review focuses on the relationship between E2F1, growth factors and cytokines.
that E2F1 mRNA stability and E2F1 protein levels are reduced in cells lacking RALY (zeige RALY Proteine) expression
our results indicate that E2F1 is an important downstream gene of ISX (zeige ISX Proteine) in hepatoma progression.
found that human E2F1 competes with YAP (zeige YAP1 Proteine) for TEAD1 (zeige TEAD1 Proteine) binding, affecting YAP (zeige YAP1 Proteine) activity, indicating that this mode of cross-regulation is conserved
E2F1-mediated hPOMC transcription is a potential target for suppressing ACTH (zeige POMC Proteine) production in ectopic Cushing's syndrome.
Results suggest that E7 recruited CUL2 (zeige CUL2 Proteine), driven by CUL2 (zeige CUL2 Proteine)/E2F1/miR (zeige MLXIP Proteine)-424 regulatory loop, is overexpressed and accelerates HPV16-induced cervical carcinogenesis.
p63alpha protein up-regulates heat shock protein 70 (zeige HSP70 Proteine) expression via E2F1 transcription factor 1 (zeige HNF1A Proteine), promoting Wasf3/Wave3 (zeige WASF3 Proteine)/MMP9 (zeige MMP9 Proteine) signaling and bladder cancer invasion
The evidence has been presented that the retinoblastoma protein utilizes a cell-cycle-independent interaction with E2F1 to recruit EZH2 (zeige EZH2 Proteine) to diverse repeat sequences.
germ-line loss of E2f1 or E2f3b, but not E2f3a, protected mice against hepatocellular carcinoma
E2F1 hinders skin wound healing by suppressing VEGF (zeige VEGFA Proteine) expression, neovascularization, and macrophage recruitment. Strategies that target E2F1 may enhance wound healing.
systems-level control of cell cycle arrest by pRB (zeige PGR Proteine)-E2F and p27 (zeige CDKN1B Proteine)-CDK (zeige CDK4 Proteine) regulation, is reported.
TERT (zeige TERT Proteine) has a role in neointima formation through epigenetic regulation of proliferative E2F1 target gene expression in smooth muscle cells.
inhibition of PDK4 (zeige PDK4 Proteine) activity in Hepatocellular carcinoma cells increased cyclin E1 (zeige CCNE1 Proteine), cyclin A2 (zeige CCNA2 Proteine), and E2F1 proteins.
Data indicate that adenosine and CGS21680 upregulate CD39 (zeige ENTPD1 Proteine) and CD73 via E2F-1 and CREB (zeige CREB1 Proteine).
Expression of Kv10.1 (zeige KCNG3 Proteine) driven by phosphorylated Rb/E2F1 contributes to G2/M progression of cancer and non-transformed cells.
Spinal cord injury-induced activation of E2F1-2 mediates cell cycle activation, contributing to gliopathy and neuronal/tissue loss associated with motor impairments and post-traumatic hyperesthesia.
Xphb1 represses E2F1 activity.
SIM (zeige SIM2 Proteine) and SMR1 are involved in hyperphosphorylation of the cell-cycle regulator RBR1 and overexpression of E2F target genes.
S6K1 interacts with retinoblastoma protein RBR via its N-terminal RBR binding motif, promotes its nuclear localization and consequent RBR-dependent repression of cell cycle genes through transcription factor E2FB.
The Arabidopsis (Arabidopsis thaliana) DEL1 gene was identified as a transcriptional target of the classical E2Fb and E2Fc transcription factors.
The authors found that S6K1 associates with the Retinoblastoma-related 1 (RBR1)-E2FB complex and this is partly mediated by its N-terminal LVxCxE motif.
Results suggest that E2FB is one of the key targets for auxin to determine whether cells proliferate or whether they exit the cell cycle, enlarge, and endoreduplicate their DNA.
AtE2Fa and AtE2Fb have specific expression patterns and may play similar but distinct roles during cell cycle progression.
The protein encoded by this gene is a member of the E2F family of transcription factors. The E2F family plays a crucial role in the control of cell cycle and action of tumor suppressor proteins and is also a target of the transforming proteins of small DNA tumor viruses. The E2F proteins contain several evolutionally conserved domains found in most members of the family. These domains include a DNA binding domain, a dimerization domain which determines interaction with the differentiation regulated transcription factor proteins (DP), a transactivation domain enriched in acidic amino acids, and a tumor suppressor protein association domain which is embedded within the transactivation domain. This protein and another 2 members, E2F2 and E2F3, have an additional cyclin binding domain. This protein binds preferentially to retinoblastoma protein pRB in a cell-cycle dependent manner. It can mediate both cell proliferation and p53-dependent/independent apoptosis.
, E2-promoter binding factor
, PRB-binding protein E2F-1
, retinoblastoma-associated protein 1
, retinoblastoma-binding protein 3
, transcription factor E2F1
, E2F-1 transcription factor