CHEK1 Proteine (CHEK1)

The protein encoded by this gene belongs to the Ser/Thr protein kinase family. It is required for checkpoint mediated cell cycle arrest in response to DNA damage or the presence of unreplicated DNA. This protein acts to integrate signals from ATM and ATR, two cell cycle proteins involved in DNA damage responses, that also associate with chromatin in meiotic prophase I. Phosphorylation of CDC25A protein phosphatase by this protein is required for cells to delay cell cycle progression in response to double-strand DNA breaks. Several alternatively spliced transcript variants have been found for this gene.

• checkpoint kinase 1 (CHEK1)
• serine/threonine-protein kinase chk1 (ANI_1_2436074)
• serine/threonine-protein kinase chk1 (AOR_1_768154)
• serine/threonine-protein kinase Chk1 (PTRG_04183)
• CAMK/CAMKL/CHK1 protein kinase Chk1 (SJAG_01680)
• Alle Gen-Bezeichnungen
• serine/threonine-protein kinase chk1 (PAAG_04978)
• serine/threonine-protein kinase chk1 (MCYG_03290)
• serine/threonine-protein kinase chk1 (VDBG_03742)
• checkpoint kinase 1 S homeolog (chek1.S)
• checkpoint kinase 1 (Chek1)
• checkpoint kinase 1 (chek1)

• An08g10320 Protein
• AO090003000441 Protein
• C85740 Protein
• CHEK1 Protein
• Chk1 Protein
• Alle Synonyme
• id:ibd2720 Protein
• rad27 Protein
• zgc:56093 Protein

CHK1 checkpoint homolog , Serine/threonine-protein kinase Chk1-like protein , serine/threonine-protein kinase Chk1 , serine/threonine-protein kinase chk1 , Checkpoint, S. pombe, homolog of, 1 , Chk1-S , cell cycle checkpoint kinase , checkpoint kinase-1 , Chk1 checkpoint kinase , xChk1 , checkpoint kinase 1 homolog , rad27 homolog , 2720 , integral membrane protein 1