anti-Ratte (Rattus) ATM Antikörper für Immunofluorescence (Paraffin-embedded Sections)

Recommended ATM Antibody (geliefert von: Anmelden zum Anzeigen )

Antigen
Ataxia Telangiectasia Mutated (ATM) Antikörper
  • ATM
  • Atm
  • CG6535
  • Dmel\\CG6535
  • Tefu
  • atm
  • atm/tefu
  • dATM
  • tef
  • Xatm
  • at1
  • atdc
  • tel1
  • telo1
  • AT1
  • ATA
  • ATC
  • ATD
  • ATDC
  • ATE
  • TEL1
  • TELO1
  • AI256621
  • C030026E19Rik
  • telomere fusion
  • ATM serine/threonine kinase L homeolog
  • ATM serine/threonine kinase
  • ataxia telangiectasia mutated
  • ataxia telangiectasia mutated (atm)
  • serine/threonine-protein kinase ATM
  • tefu
  • atm.L
  • atm
  • ATM
  • EDI_100660
  • CpipJ_CPIJ001772
  • BDBG_08252
  • PAAG_02532
  • MCYG_05088
  • VDBG_06833
  • ACLA_015700
  • LOC5565620
  • MGYG_07634
  • PGTG_14279
  • Atm
Epitop
AA 2700-2750
89
35
18
17
16
15
10
7
6
6
6
6
5
5
4
4
3
3
3
3
3
3
2
2
2
2
2
2
2
1
1
1
1
1
1
1
1
1
1
1
Reaktivität
Human, Maus, Ratte (Rattus)
360
159
81
29
8
1
1
1
1
Wirt
Kaninchen
234
105
13
8
3
1
Klonalität
Polyklonal
Konjugat
Dieser ATM Antikörper ist unkonjugiert
12
11
9
8
8
6
5
5
3
3
3
3
3
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
1
1
1
Applikation
Flow Cytometry (FACS), Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p)), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))
227
144
116
85
83
64
56
44
26
22
12
9
4
4
2
2
2
1
1
Optionen
Hersteller
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Bilder

Produktnummer ABIN685582
$ 306.90
Zzgl. Versandkosten $45.00
Relevance Score ABIN Application Konjugat Host Isotype Epitope Hersteller Clonality References Details
1 ABIN685585 FACS IF (cc) IF (p) Cy3 Rabbit IgG AA 2700-2750 Anmelden zum Anzeigen Polyclonal 0
1 ABIN685587 FACS IF (cc) IF (p) Cy5.5 Rabbit IgG AA 2700-2750 Anmelden zum Anzeigen Polyclonal 0
1 ABIN685588 FACS IF (cc) IF (p) Cy7 Rabbit IgG AA 2700-2750 Anmelden zum Anzeigen Polyclonal 0
1 ABIN685586 FACS IF (cc) IF (p) Cy5 Rabbit IgG AA 2700-2750 Anmelden zum Anzeigen Polyclonal 0
1 ABIN685589 FACS IF (cc) IF (p) FITC Rabbit IgG AA 2700-2750 Anmelden zum Anzeigen Polyclonal 0
1 ABIN884036 FACS IF (cc) IF (p) Alexa Fluor 555 Rabbit IgG AA 2700-2750 Anmelden zum Anzeigen Polyclonal 0
1 ABIN884037 FACS IF (cc) IF (p) Alexa Fluor 350 Rabbit IgG AA 2700-2750 Anmelden zum Anzeigen Polyclonal 0
1 ABIN884038 FACS IF (cc) IF (p) Alexa Fluor 488 Rabbit IgG AA 2700-2750 Anmelden zum Anzeigen Polyclonal 0
1 ABIN884039 FACS IF (cc) IF (p) Alexa Fluor 647 Rabbit IgG AA 2700-2750 Anmelden zum Anzeigen Polyclonal 0
1 ABIN2808094 FACS IF (cc) IF (p) Alexa Fluor 594 Rabbit IgG AA 2700-2750 Anmelden zum Anzeigen Polyclonal 0
1 ABIN679103 IF (p) IHC (p) Rabbit IgG pSer1981 Anmelden zum Anzeigen Polyclonal 2
1 ABIN4997012 FACS IF (cc) IF (p) Alexa Fluor 680 Rabbit IgG AA 2700-2750 Anmelden zum Anzeigen Polyclonal 0
1 ABIN4997013 FACS IF (cc) IF (p) Alexa Fluor 750 Rabbit IgG AA 2700-2750 Anmelden zum Anzeigen Polyclonal 0

General

Antigen Ataxia Telangiectasia Mutated (ATM) Antikörper
Epitop AA 2700-2750
(89), (35), (18), (17), (16), (15), (10), (7), (6), (6), (6), (6), (5), (5), (4), (4), (3), (3), (3), (3), (3), (3), (2), (2), (2), (2), (2), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Reaktivität Human, Maus, Ratte (Rattus)
(360), (159), (81), (29), (8), (1), (1), (1), (1)
Wirt Kaninchen
(234), (105), (13), (8), (3), (1)
Klonalität
Polyklonal
Konjugat Dieser ATM Antikörper ist unkonjugiert
(12), (11), (9), (8), (8), (6), (5), (5), (3), (3), (3), (3), (3), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (1), (1), (1)
Applikation Flow Cytometry (FACS), Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p)), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))
(227), (144), (116), (85), (83), (64), (56), (44), (26), (22), (12), (9), (4), (4), (2), (2), (2), (1), (1)
Pubmed 1 Publikation vorhanden
Hersteller Anmelden zum Anzeigen

Produktdetails anti-ATM Antikörper

Target Details ATM Anwendungsinformationen Handhabung Referenzen für anti-ATM Antikörper (ABIN685582) Bilder
Reinigung Purified by Protein A.
Immunogen KLH conjugated synthetic peptide derived from mouse ATM
Isotyp IgG

Target Details ATM

Produktdetails anti-ATM Antikörper Anwendungsinformationen Handhabung Referenzen für anti-ATM Antikörper (ABIN685582) Bilder zurück nach oben
Antigen
Andere Bezeichnung Atm (ATM Antibody Abstract)
Hintergrund

Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]-Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and monospecific recognition by the B-cell antigen receptor (BCR) expressed on individual B-lymphocytes. After the introduction of DNA breaks by the RAG complex on one immunoglobulin allele, acts by mediating a repositioning of the second allele to pericentromeric heterochromatin, preventing accessibility to the RAG complex and recombination of the second allele. Also involved in signal transduction and cell cycle control. May function as a tumor suppressor. Necessary for activation of ABL1 and SAPK. Phosphorylates DYRK2, CHEK2, p53/TP53, FANCD2, NFKBIA, BRCA1, CTIP, nibrin (NBN), TERF1, RAD9 and DCLRE1C. May play a role in vesicle and/or protein transport. Could play a role in T-cell development, gonad and neurological function. Binds DNA ends. Plays a role in replication-dependent histone mRNA degradation. Phosphorylation of DYRK2 in nucleus in response to genotoxic stress prevents its MDM2-mediated ubiquitination and subsequent proteasome degradation. Phosphorylates ATF2 which stimulates its function in DNA damage response.

Subcellular location: Cytoplasm, Nucleus

Synonyms: AI256621, C030026E19Rik, Serine-protein kinase ATM, Ataxia telangiectasia mutated homolog, A-T mutated homolog, Atm

Gen-ID 11920
UniProt Q62388
Pathways p53 Signalweg, Apoptose, DNA Reparatur, Inositol Metabolic Process, Positive Regulation of Response to DNA Damage Stimulus

Anwendungsinformationen

Produktdetails anti-ATM Antikörper Target Details ATM Handhabung Referenzen für anti-ATM Antikörper (ABIN685582) Bilder zurück nach oben
Applikations-hinweise FCM 1:20-100
IHC-P 1:100-500
IF(IHC-P) 1:50-200
IF(ICC) 1:50-200
Beschränkungen Nur für Forschungszwecke einsetzbar

Handhabung

Produktdetails anti-ATM Antikörper Target Details ATM Anwendungsinformationen Referenzen für anti-ATM Antikörper (ABIN685582) Bilder zurück nach oben
Format Liquid
Konzentration 1 μg/μL
Buffer Aqueous buffered solution containing 1 % BSA, 50 % glycerol and 0.09 % sodium azide.
Konservierungs-mittel Sodium azide
Vorsichtsmaßnahmen This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.
Lagerung -20 °C
Informationen zur Lagerung Store at -20°C
Haltbarkeit 12 months

Referenzen für anti-ATM Antikörper (ABIN685582)

Produktdetails anti-ATM Antikörper Target Details ATM Anwendungsinformationen Handhabung Bilder zurück nach oben
Produkt verwendet in:

Liu, Yang, Jing, Ren, Wei, Zhang, Zhang, Duan, Zhou, Sun: "Silica nanoparticle exposure inducing granulosa cell apoptosis and follicular atresia in female Balb/c mice." in: Environmental science and pollution research international, Vol. 25, Issue 4, pp. 3423-3434, 2017 Von den Autoren verwendete Methode: Western Blotting (WB) (Probematerial (Species): Mouse (Murine)). Weitere Details: Sample: ovary

Bilder

Produktdetails anti-ATM Antikörper Target Details ATM Anwendungsinformationen Handhabung Referenzen für anti-ATM Antikörper (ABIN685582) zurück nach oben
Bilder des Herstellers
Immunohistochemistry (IHC) image for anti-Ataxia Telangiectasia Mutated (ATM) (AA 2700-2750) antibody (ABIN685582) Formalin-fixed and paraffin embedded human lung carcinoma labeled with Anti-ATM Polyc...
Immunohistochemistry (IHC) image for anti-Ataxia Telangiectasia Mutated (ATM) (AA 2700-2750) antibody (ABIN685582) Formalin-fixed and paraffin embedded human cervical cancer labeled with Anti-ATM Poly...
Immunofluorescence (Cultured Cells) (IF (cc)) image for anti-Ataxia Telangiectasia Mutated (ATM) (AA 2700-2750) antibody (ABIN685582) Image provided by One World Lab validation program. A549 cells probed with Rabbit Ant...