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ARFGAP1 (zeige ARFGAP3 ELISA Kits) is found associated with lipid droplets at steady state in some but not all hepatocytes.
ARFGAP1 (zeige ARFGAP3 ELISA Kits) is a host factor for Hepatitis C Virus RNA replication, and is hijacked by HCV NS5A to remove COPI cargo Sac1 (zeige SACM1L ELISA Kits) from the site of HCV replication to maintain high levels of PI4P.
ArfGAP1 (zeige ARFGAP3 ELISA Kits) is identified as the first GTPase activating protein (GAP) for leucine-rich repeat kinase 2 (LRRK2 (zeige LRRK2 ELISA Kits)).
role of ARFGAP1 (zeige ARFGAP3 ELISA Kits) in AP-2 (zeige GTF3A ELISA Kits)-regulated endocytosis has mechanistic parallels with its roles in COPI transport, as both its GAP activity and coat function contribute to promoting AP-2 (zeige GTF3A ELISA Kits) transport
The small GTPases of the Ras superfamily mediate numerous biological processes through their ability to cycle between an inactive GDP-bound and an active GTP (zeige AK3 ELISA Kits)-bound form.
ArfGAP1 (zeige ARFGAP3 ELISA Kits) interacts with the Golgi through multiple hydrophobic motifs and that alternative modes of interaction may exist in tissue-specific ArfGAP1 (zeige ARFGAP3 ELISA Kits) isoforms.
SMAP2 (zeige BRD8 ELISA Kits) functions in the retrograde, early endosome-to-trans golig network pathway in a clathrin- and AP-1 (zeige FOSB ELISA Kits)-dependent manner.
coatomer (zeige ARCN1 ELISA Kits) is an allosteric regulator of Arf GAP1
Differential roles of ArfGAP1 (zeige ARFGAP3 ELISA Kits), ArfGAP2 (zeige arfgap2 ELISA Kits), and ArfGAP3 (zeige ARFGAP3 ELISA Kits) in COPI trafficking
ArfGAP1 (zeige ARFGAP3 ELISA Kits), ArfGAP2 (zeige arfgap2 ELISA Kits), and ArfGAP3 (zeige ARFGAP3 ELISA Kits) have overlapping roles in regulating COPI function in Golgi-to-ER retrograde transport.
termination of Arf1 (zeige ARF1 ELISA Kits) signals mediated through GGA require that Arf1 (zeige ARF1 ELISA Kits).GTP (zeige AK3 ELISA Kits) dissociates from GGA prior to interaction with GAP and consequent hydrolysis of GTP (zeige AK3 ELISA Kits)
The protein encoded by this gene is a GTPase-activating protein (GAP) which associates with the Golgi apparatus and which interacts with ADP-ribosylation factor 1 (ARF1). The encoded protein promotes hydrolysis of ARF1-bound GTP and is required for the dissociation of coat proteins from Golgi-derived membranes and vesicles. Dissociation of the coat proteins is required for the fusion of these vesicles with target compartments. The activity of this protein is stimulated by phosphoinosides and inhibited by phosphatidylcholine. Two transcript variants encoding different isoforms have been found for this gene.
ADP-ribosylation factor GTPase-activating protein 1
, ARF1-directed GTPase-activating protein
, ADP-ribosylation factor 1 GTPase activating protein
, ADP-ribosylation factor 1 GTPase-activating protein
, ARF GAP 1
, ARF1 GAP
, ADP-ribosylation factor GTPase activating protein 3
, ADP-ribosylation factor GTPase activating protein 1
, ATP-dependent RNA helicase DBP9