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Removal of this side chain enhances the binding affinity by more than fivefold, suggesting that access of Crb to Pals1 may be regulated by intradomain contacts or by protein-protein interaction.
The unique in-frame MPP5-FAM71D fusion product is important for proliferation of PC346C cells.
the crystal structure of a 4-L27 domain-containing heterotrimer derived from the tripartite complex Patj/Pals1/Mals2
Crystals of tripartite complex 1 of L27(PATJ)-(L27N,L27C)(Pals1)-L27(MALS) diffracted to 2.05 A resolution
Small irregularly shaped spots are detected throughout the Pals1-deficient retina of conditional knockdown mice by confocal scanning laser ophthalmoscopy and spectral domain optical coherence tomography.
The cell polarity protein PALS1 is expressed in T lymphocytes and participates to the optimal activation of NF-kappaB following TCR stimulation.
Data suggest that hijacking of PALS1 by SARS-CoV E plays a determinant role in the disruption of the lung epithelium in SARS patients.
Polycystin-2 activity is controlled by transcriptional coactivator with PDZ binding motif and PALS1-associated tight junction protein
Polarity protein associated with lin seven 1 (Pals1) plays an essential role in radical and longitudinal extension of the myelin sheath in peripheral nerves, likely involving membrane protein trafficking.
Pals1 functions as an adapter, linking mammalian homologues of Crumbs and Discs Lost.
the Crumbs3-Pals1 complex has a role in development of polarity in mammalian epithelial cells
PDZ domain plasticity has a role in internal recognition in the Par-6-Pals1 complex
the importance of a conserved Crumbs-MPP5-EPB41L5 polarity complex in mammals for separation of the apical and basolateral domains through specialized cell-cell junctions
This study shows that Spatial-temporal expressions of Nagie oko and their interdependence in zebrafish central nervous system during early development.
The structural disorganization of the pronephric glomerulus in the mpp5a(m520) mutant is likely to result from circulatory failure, rather than the anomaly of Mpp5a protein in the glomerulus.
the ratio of the number of cells undergoing neurogenic cell division to the total number of cells undergoing mitosis was decreased in retinas of nagie oko knockout zebrafish.
morphogenesis of the neural tube requires nok function
Heart and soul/PRKCi and nagie oko/Mpp5 regulate myocardial coherence and remodeling during cardiac morphogenesis.
Data show that nagie oko contains a predicted nuclear export and two conserved nuclear localization signals and loss of the predicted nuclear export signal results in nuclear protein accumulation.
deletion constructs of Nok in functional rescue experiments to define domains essential for cell polarity, maintenance of epithelial integrity and cardiac morphogenesis.Nok does not interact with Crumbs proteins upon deletion of the PDZ domain
that Nok is required for retinal pigment epithelium integrity in a tissue-autonomous manner
This gene encodes a member of the p55-like subfamily of the membrane-associated guanylate kinase (MAGUK) gene superfamily. The encoded protein participates in the polarization of differentiating cells, has been shown to regulate myelinating Schwann cells (PMID: 20237282), and is one of the components of the Crumbs complex in the retina. Mice which express lower levels of the orthologous protein have retinal degeneration and impaired vision (PMID: 22114289). Multiple transcript variants encoding different isoforms have been found for this gene.
MAGUK p55 subfamily member 5
, protein associated with lin seven 1
, protein associated with Lin Seven 1
, membrane protein, palmitoylated 3 (MAGUK p55 subfamily member 5)
, protein associated with Lin-7 1
, MAGUK family factor
, MAGUK p55 subfamily member 5-A
, membrane protein, palmitoylated 5 (MAGUK p55 subfamily member 5)
, nagie oko protein