anti-Retinoic Acid Receptor alpha (RARA) Antikörper

Human Retinoic Acid Receptor, alpha (RARA) Interaktionspartner

1. Our results demonstrate that the majority of RARA-negative acute promyelocytic leukemia (APL) have RARB translocations, thereby forming a novel, distinct subgroup of APL. TBL1XR1-RARB as an oncogenic protein exerts effects similar to those of PML-RARA, underpinning the importance of retinoic acid pathway alterations in the pathogenesis of APL.

2. findings showed that the IRF2BP2-RARalpha fusion has the capacity to transform primary hematopoietic stem/progenitor cells and induced an ATRA-responsive acute promyelocytic leukemia (APL); this provides further evidence that formation of RARA fusion genes represent disease-defining mutations in APL pathogenesis

3. RARA and RARG gene downregulation associated with EZH2 mutation in acute promyelocytic-like morphology leukemia

4. BRD4 and PML/RARalpha co-existed on the same regulatory regions of their target genes. Hence, the study showed a new discovery of the interaction of BRD4 and PML/RARalpha, as well as the decline of PML/RARalpha expression in NB4 cells, under JQ1 treatment.

5. RARalpha contributed to the malignancy of Esophageal Carcinoma.

6. Despite the rarity of acute promyelocytic leukemia (APL) cases with an atypical PML/RARA fusion, our study indicates that an integrated laboratory approach, employing several diagnostic techniques is crucial to timely diagnose APL. This approach allows prompt initiation of specific targeted treatment and reliable MRD monitoring in atypical APL cases.

7. in response to RA, TRIM24 serves as an adapter linking RARalpha to the proteasome for its degradation. In addition, TRIM24 and the proteasome are recruited with RARalpha to the promoters of target genes and thus are inherently linked to RARalpha transcriptional activity.

8. increased expression of ALDH1A1-RDH10-RARalpha- PPARbeta/delta pattern could be considered as adverse prognostic factor associated with a higher concentration of paraprotein and worst overall survival of patients with newly diagnosed multiple myeloma.

9. The results of study demonstrate that increased level of expression in the first instance of isoform RARa in combination with hyper-expression of isoform RARbeta but not RARa can have unfavorable significance in case of evaluation of response to medicinal therapy and prognosis of total survival in patients with multiple melanoma.

10. Recurrent STAT3-RARA fusion is associated with acute promyelocytic leukemia lacking t(15;17)(q22;q12)/PML-RARA

11. PML and RARA breakpoint translocation is associated with acute promyelocytic leukemia.

12. Semiquantitative and quantitative analyses of the markers RARA and CRABP2 indicate their potential as biomarkers for tumor progression and their participation in nephroblastoma tumorigenesis

13. The level of RARalpha gene expression as a potential prognostic factor in the pathogenesis of multiple myeloma.

14. The data demonstrate that RARalpha drives integrin beta7-dependent adhesion and CCR9-mediated chemotaxis in CTCL cells.

15. These results therefore indicate that EGCG targets PML/RARalpha oncoprotein for degradation and potentiates differentiation of promyelocytic leukemia cells in combination with ATRA via PTEN.

16. Silencing of PML-RAR and RARalpha2 results in similar increases in the constitutive expression of several granulocytic differentiation markers.

17. RARA drives cyclin-dependent kinase expression, G1-S transition, and cell growth in T-cell lymphoma.

18. Demonstrate that RARalpha was frequently elevated in gastric carcinoma and exerted oncogenic properties via positive feedback loop of IL-1beta/Akt/RARalpha/Akt signaling.

19. Our findings unveil a novel essential oncogenic activity of PML/RARA in Acute promyelocitic leukemia

20. Findings reveal a previously unrecognized role of c-Myc as a potential ceRNA for PML/RARalpha in acute promyelocytic leukemia.

Mouse (Murine) Retinoic Acid Receptor, alpha (RARA) Interaktionspartner

1. this study shows that RAR-alpha represses a Th9 transcriptional and epigenomic program to reduce allergic pathology

2. RARA produced in male germ cells has a broad spectrum of functions throughout spermatogenesis, which includes the maintenance of seminiferous epithelium organization, the integrity of the meiotic genome, and spermatogonial proliferation and differentiation.

3. This study used CRISPR technology to introduce biallelic frameshift mutations in RAR alpaha, RAR beta, and RAR gamma, thereby abrogating all RAR functions in murine embryonic stem cells. RAR-null cells display no changes in transcripts in response to All-trans-retinoic acid (RA), demonstrating that the RARs are essential for the regulation of all transcripts in murine embryonic stem cells in response to RA.

4. Data show that the development of langerhans cells (LC) from embryonic and bone marrow-derived progenitors and langerin(+ )conventional dendritic cells (DC) is regulated by the retinoic acid receptor alpha (RARalpha)-retinoic acid (RA) axis.

5. these findings indicate that epithelial cell-intrinsic RARalpha signaling is critical to the global development of the intestinal immune system

6. This study demonstrates that RA signaling is required in steroidogenic cells for their normal function and, thus, for male fertility.

7. RARalpha and RARgamma reciprocally control K5(+) progenitor cell proliferation and distribution in the developing submandibular salivary epithelium in a cell cycle-dependent manner while regulating lumenization independently of keratinizing differentiation

8. RARalpha competes with other PFN2a-binding proteins bearing PRMs and involved in actin filaments elongation. Consequently, the actin filament network is altered and MEFs adhesion is decreased. This novel role opens novel avenues for the understanding of pathologies characterized by increased levels of cytoplasmic RARalpha.

9. These data suggest that impairment of cardiac RARalpha signaling may be a novel mechanism that is directly linked to pathological stimuli-induced diastolic dysfunction.

10. Retinoic acid receptor alpha agonist all trans retinoic acid can protect the liver from ischemia reperfusion injury by promoting autophagy, which is dependent on Foxo3/p-Akt/Foxo1 signaling.

11. both the PML-RARA-driven competitive transplantation advantage and development of acute promyelocytic leukemia (APL) required DNMT3A

12. the reprogramming of epiblast stem cells into embryonic stem cell-like cells also requires low levels of retinoic acid (RA), which can modulate Wnt signalling through physical interactions of RARs with beta-catenin.

13. our findings challenge the predominant model in the field and we propose that PML/RARA initiates leukemia by subtly shifting cell fate decisions within the promyelocyte compartment.

14. DNA-binding-defective PML/RARA mutants could not repress the transcription of retinoic acid regulated genes.

15. although X-RARA fusion proteins have been suggested to act by blocking retinoid-dependent transcriptional programs , we observed a surprising paucity of natural retinoids capable of transactivating Gal4-RARA in primary mouse bone marrow cells

16. The results indicate a physiological role for RARgamma as a negative regulator of osteoclastogenesis in vivo and in vitro, and reveal distinct influences of RARalpha and RARgamma in bone structure regulation.

17. Data suggest that retinoic acid and GM-CSF-induced retinal dehydrogenase 2 (RALDH2) expression in dendritic cells requires cooperative binding of transcription factor Sp1 via the RA receptor/retinoid X receptor complex to the Aldh1a2 promoter.

18. Retinoic acid-RARalpha as a key component of the regulatory network governing maintenance and plasticity of Th1-cell fate.

19. atRA signaling mediated by RARa is required in the adult pancreas for maintaining both beta-cell function and mass

20. Data suggest that acute promyelocytic leukemia (APL) differentiation is a default program triggered by clearance of promyelocytic leukemia-retinoic acid receptor alpha fusion oncoprotein PML/RARA-bound promoters.

Cow (Bovine) Retinoic Acid Receptor, alpha (RARA) Interaktionspartner

1. Increased expression of mammary TRbeta1 and DIO2, and decreased RXRalpha, provide a mechanism to increase thyroid hormone activity within the mammary gland during lactation.

Zebrafish Retinoic Acid Receptor, alpha (RARA) Interaktionspartner

1. Retinoic acid (RA)-responsive genes are differentially sensitive to alterations in the RA pathway and, in particular, cyp26a1 and raraa are under a high pressure to maintain signaling integrity.

2. The RA receptors RXR gamma and RAR alpha-b are expressed in patterns consistent with mediating the effects of RA on photoreceptors.

Xenopus laevis Retinoic Acid Receptor, alpha (RARA) Interaktionspartner

1. results show role for retinoic acid receptor as a regulator of spatial patterning of the pre-placodal ectoderm (PPE)through Tbx1 and RIPPLY3; demonstrate that Ripply3, acting downstream of RAR signaling, is key player in establishing boundaries in the PPE