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heat shock proteins are involved in PDX1-mediated effects on the genesis of gastric cancer
Investigated the effect of gestational diabetes mellitus (GDM) on the expression and methylation of PGC-1alpha and PDX1 in placenta and their effects on fetal glucose metabolism. Blood glucose was negatively correlated with the expression of PGC-1alpha and PDX1 mRNA in the placenta.
PDX1, Neurogenin-3, and MAFA are critical transcription regulators for beta cell development and regeneration. (Review)
study provides a novel culture protocol for generating pancreas-committed cells from hAECs and reveals an interplay between Pdx1 and activin A/nicotinamide signaling in early pancreatic fate determination.
Data indicate the secretory granule membrane glycoprotein 2 as a marker for PDX1+/NKX6-1+ pancreatic progenitors (PPs).
expression of regulatory master genes of embryonic development in pancreatic cancer cells on the intracellular concentration of the master regulator PDX1
Efficiency of differentiation of Induced pluripotent stem cells to insulin producing cells can be increased by concurrent expression of PDX1 and NKX6.1 during progenitor cells maturation.
Mutation in PDX1 gene is associated with Maturity Onset Diabetes of the Young.
Results found that Pdx-1 overexpression exerts its effects on islet cell replication via a noncell-autonomous mechanism involving induction of a secreted soluble factor or factors. Also, Inhbb is identified as one factor mediating the proliferative effect of Pdx-1.
Our findings indicate that MET induces the differentiation of Pdx1-expressing cells within the definitive endoderm in a time-dependent manner, and suggest useful application for regenerative medicine.
Pdx1 and MafA play crucial roles in the pancreas and maintain mature beta-cell function. Our results showed that the expression of Pdx1 and MafA were significantly upregulated after a sleeve gastrectomy for morbid obesity.
Data show that the expression patterns of sex determining region Y-box 2 (SOX2) and pancreatic and duodenal homeobox 1 (Pdx1)) highly correlated with prognosis of pancreatic neuroendocrine tumors (p-NETs).
The ERK-PDX-1 interaction in PANC-1 cells.
Foxo1 and PDX1 are colocalized in fetal pancreatic islets, suggesting they function in parallel in beta cells.
This study investigated the role of Pdx1 and its mechanism in differentiating induced pluripotent stem cells (iPSCs) into islet beta cells.
the human Pdx1 is highly effective in triggering human biliary tree stem cells differentiation toward functional beta-pancreatic cells.
Introduction of the PDX1 gene makes cells acquire a functional insulin secretory capacity
These results suggest that IFN-gamma induced beta-cell dysfunction is mediated through decreased nuclear localization of Pdx-1.
The rs12255372 SNP of TCF7L2 and D76N of PDX-1 genes may confer susceptibility to T2DM in the population living in Mashhad, Iran.
Pdx1 has a role in pancreatic differentiation in human amniotic fluid-derived stem cells
Report pancreatic expression of Pdx-1 in pancreas.
Maturation of pancreatic beta-cells requires Pdx1 function in cooperation with Foxa2.
The dynamic undifferentiated cell states within the male germline expressing PDX1 have been found and characterized.
results indicated that conditioned medium, just as critical components of the stem cell niche associated with other factors, such as Pdx1, had high potential to differentiate mESCs into IPCs
the present study demonstrated that Pdx1+/-/Alzheimer mice exhibit enhanced cognitive decline, amyloid-beta plaque deposition, tau hyperphosphorylation, the loss of synaptic spine protein, and activation of microglia and astrocytes.
This study showed that altered Pdx1 mRNA and protein levels in weaned male mutant beta-cells were tightly linked with hyperglycemia, decreased beta-cell proliferation, reduced beta-cell area, and altered expression of Pdx1-bound genes that are important in beta-cell replication, endoplasmic reticulum function, and mitochondrial activity.
These results suggest that Oc1 and Pdx1 cooperate prior to their divergence, in pancreatic progenitors, to allow for proper differentiation and functional maturation of beta cells.
Data suggest that hepatocytes can be reprogrammed into insulin-producing cells in vivo by transfection of neurogenin-3, Pdx1, and MafA genes using non-viral hydrodynamics injection; this procedure was used in treatment of streptozotocin diabetes; fasting blood glucose was reduced to normal. (Pdx1 = pancreatic and duodenal homeobox 1; MafA = v-maf musculoaponeurotic fibrosarcoma oncogene family, protein A)
PDX1 and ISL1 regulation of insulin gene expression in pancreatic beta cells, was investigated.
Creating the Pdx1(DeltaAREAII) state after cells entered an insulin-expressing stage led to immature and dysfunctional islet beta cells carrying abnormal chromatin marking in vital beta-cell-associated genes. Therefore, trans-regulatory integration through Area II mediates a surprisingly extensive range of progenitor and beta-cell-specific Pdx1 functions.
The use of a GFP reporter knocked into the endogenous Pdx1 promoter allowed us to monitor pancreatic induction based on the expression of Pdx1, a pancreatic master transcription factor, and to isolate a pure Pdx1-GFP(+) population for downstream applications.
Upon neoplastic transformation, the role of PDX1 changes from tumor-suppressive to oncogenic
PDX1 role in beta-cell function and diabetes
At the molecular level, administration of liraglutide induced the expression of PDX-1, MafA, p-JAK2 and p-Stat3 in high-fat diet-induced diabetes model to relatively normal levels.
Diabetes Caused by Elastase-Cre-Mediated Pdx1 Inactivation
These results suggest that Bax mediates beta-cell apoptosis in Pdx1-deficient diabetes.
the role of Epidermal Growth Factor (EGF) and Poly-L-Ornithine (PLO) and PDX1 on human amnion epithelial cell differentiation process, is reported.
Ets-1 links glucotoxicity to pancreatic beta cell dysfunction through inhibiting PDX-1 expression in type 2 diabetes.
Data indicate that KrasG12D;Pdx1-Cre mouse model enables one to monitor the progression of pancreatic cancer (PC) from the onset of precursor lesions to cancer development.
Pdx1+Sox9 co-occupy regulatory sequences of pancreatic and intestinal genes. Pdx1+Sox9 are necessary and sufficient to repress the intestinal fate choice.
The paper identifies two conserved Pdx1 binding sites in the epithelial cadherin (E-cad, Cdh1) promoter, and shows that Pdx1 directly binds and activates E-cad transcription.
Diabetic pdx1-mutant zebrafish show conserved responses to nutrient overload and anti-glycemic treatment
A pdx1-dependent progenitor population essential for the formation of duct-associated, second wave endocrine cells, is demonstrated.
Pdx-1 plays multiple roles in maintaining the phenotype of the islet during embryogenesis.
The protein encoded by this gene is a transcriptional activator of several genes, including insulin, somatostatin, glucokinase, islet amyloid polypeptide, and glucose transporter type 2. The encoded nuclear protein is involved in the early development of the pancreas and plays a major role in glucose-dependent regulation of insulin gene expression. Defects in this gene are a cause of pancreatic agenesis, which can lead to early-onset insulin-dependent diabetes mellitus (NIDDM), as well as maturity onset diabetes of the young type 4 (MODY4).
, glucose-sensitive factor
, insulin promoter factor 1, homeodomain transcription factor
, insulin upstream factor 1
, islet/duodenum homeobox-1
, pancreas/duodenum homeobox protein 1
, pancreatic-duodenal homeobox factor 1
, somatostatin transcription factor 1
, somatostatin-transactivating factor 1
, homeodomain protein PDX-1
, pancreatic and duodenum homeobox 1
, pancreatic duodenal homeobox gene 1
, pancreatic and duodenal homeobox 1
, islet/duodenum homeobox 1
, pancreatic and duodenal homeobox gene 1
, Insulin promoter factor 1
, insulin promotor factor 1
, somatostatin transactivating factor 1
, homeodomain protein PDX1
, Homeobox protein 8
, XlHbox 8 protein
, LOW QUALITY PROTEIN: pancreas/duodenum homeobox protein 1
, Homeodomain protein PDX1