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GCNF acts as a transcriptional repressor in the regulation of OCT4 gene expression through cooperative interaction with three NR binding elements in pluripotent NCCIT cells.
the genes, and up-regulated 64% in undifferentiated hES cells. In addition, GCNF also showed a regulatory gene pattern that is different from RA treatment during hES cell differentiation
Findings show a role for Gcnf as a regulator of iPS cell pluripotency gene expression. It also demonstrates that reactivation of the Gcnf gene may serve as a marker to distinguish completely reprogrammed iPS cells from incompletely pluripotent cells.
Our results show that cellular levels of NR6A1 are correlated with disease progression in prostate cancer.
These experiments confirmed that NR6A1 works as a regulator for hypocretin transcription.
RTR mRNA was expressed in the human placental choriocarcinoma cell lines BeWo, JAR, and JEG-3.
characterization of a novel nuclear protein, referred to as RAP80, that interacts with the retinoid-related testis-associated receptor
down-regulation of CREMtau-mediated gene expression by GCNF
Here, the authors present the first structure of mouse GCNF DNA-binding domain in complex with the Oct4 DR0. The overall structure revealed two molecules bound in a head-to-tail fashion on opposite sides of the DNA at a DR0 motif located within the Oct4 promoter.
Inactivation of the Gcnf gene in vivo leads to loss of repression of Oct4 expression in both male and female gonads.
These results reveal that GCNF plays a key role in regulating activation of cyclin D1 expression via inhibition of Mir302a.
Gcnf is expressed in fetal ovarian germ cells.
characterize the let-7 target Nr6a1, an embryonic transcriptional repressor that regulates gene expression in adult fibroblasts following miRNA loss
GCNF initiates the repression and epigenetic modification of Oct4 gene during ESC differentiation.
Examination of RTR expression in murine placental tissue by immunohistochemistry demonstrated the presence of RTR protein in the nuclei of giant trophoblasts and spongiotrophoblasts.
embryonic function is dependent on the DNA binding site
GCNF in early embryos is a maternal protein and could be involved in the regulation of zygotic gene expression and preimplantation embryonic development.
germ cell nuclear factor plays a role in transcriptional regulation during meiosis and the early haploid phase of spermatogenesis
androgen-regulated gene expressions located at the corpus principal cells might be controlled by GCNF.
GCNF-dependent repression of Bmp15 and Gdf9 mediates gamete regulation of female fertility.
germ cell nuclear factor (GCNF) may play an important role in epididymal differentiation
Germ cell nuclear factor acts as a repressor of basal transcription on both the Protamine 1 and Protamine 2 promoters.
Expression of GCNF may play important roles in spermatogenesis, capacitation and fertilization.
The level of GCNF is critical for differentiation and maturation of neuronal precursor cells.
Three hypersensitive sites were identified in the region spanning 2.1kb between the last exon of GCNF and the first exon of Ad4BP/SF-1.
GCNF has a central role in the repression of pluripotency gene expression during retinoic acid-induced embryonic stem cell differentiation
Required for establishment of the isthmic organizer, thereby regulating the midbrain development.
evidence pesented that illustrates the function of germ cell nuclear factor in the early development of the CNS [GCNF]
NR6A1, PLAG1 and VRTN are significantly associated with the number of vertebrae in Chinese Tongcheng x Large White crossbred pigs
Recent studies suggest that a missense substitution (p.Pro192Leu) in the nuclear receptor subfamily 6, group A, member 1 (NR6A1) gene, mapped on porcine chromosome 1, is the causative mutation of a QTL affecting the number of vertebrae in pigs.
this study supports the assumption that the Western NR6A1 haplotypes were introduced into Licha Black and possibly Laiwu and are associated with increased vertebral number
Cloning and expression of the zebrafish germ cell nuclear factor.
This gene encodes an orphan nuclear receptor which is a member of the nuclear hormone receptor family. Its expression pattern suggests that it may be involved in neurogenesis and germ cell development. The protein can homodimerize and bind DNA, but in vivo targets have not been identified. The gene expresses at least alternatively spliced transcript variants.
germ cell nuclear factor variant 1
, nuclear receptor subfamily 6 group A member 1
, retinoic acid receptor-related testis-associated receptor
, retinoid receptor-related testis-specific receptor
, germ cell nuclear factor
, nuclear receptor subfamily 6, group A, member 1
, germ cell nuclear factor B
, nuclear receptor subfamily 6 group A member 1-B
, germ cell nuclear factor A
, nuclear receptor subfamily 6 group A member 1-A