anti-Maus NR4A2 Antikörper für Immunohistochemistry (Paraffin-embedded Sections)

Recommended NR4A2 Antibody

Antigen
Nuclear Receptor Subfamily 4, Group A, Member 2 (NR4A2) Antikörper
  • nr41/42/43
  • Nr4a2
  • nurr1
  • not
  • rnr1
  • hzf-3
  • tinur
  • NGFI-B
  • HZF-3
  • NOT
  • NURR1
  • RNR1
  • TINUR
  • Nurr1
  • RNR-1
  • TINOR
  • ngf1b
  • nr4a2
  • zgc:92696
  • nuclear receptor subfamily 4 group A member 2
  • nuclear receptor
  • nuclear receptor subfamily 4, group A, member 2
  • nuclear receptor subfamily 4, group A, member 2b
  • NR4A2
  • nr41/42/43
  • nr4a2
  • Nr4a2
  • nr4a2b
Epitop
AA 13-42, N-Term
9
7
6
4
3
2
2
2
2
2
1
1
1
1
1
1
Reaktivität
Human, Maus
72
24
20
6
6
5
5
5
5
3
2
2
2
2
2
1
1
Wirt
Kaninchen
53
22
Klonalität
Polyklonal
Konjugat
Dieser NR4A2 Antikörper ist unkonjugiert
2
1
1
1
1
1
1
1
Applikation
Immunofluorescence (IF), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Western Blotting (WB)
57
39
24
11
7
4
3
2
1
1
Optionen

Bilder

Produktnummer ABIN390383
$ 385.00
Zzgl. Versandkosten $45.00
Relevance Score ABIN Application Konjugat Host Isotype Epitope Clonality References Details
10 ABIN6745718 IHC IHC (p) WB Rabbit IgG N-Term Polyclonal 0
10 ABIN5537220 IF IHC (p) WB Rabbit Ig Fraction AA 13-42, N-Term Polyclonal 0
1 ABIN6243917 IHC (p) WB Rabbit Ig Fraction AA 164-197 Polyclonal 0

General

Antigen Nuclear Receptor Subfamily 4, Group A, Member 2 (NR4A2) Antikörper
Epitop AA 13-42, N-Term
(9), (7), (6), (4), (3), (2), (2), (2), (2), (2), (1), (1), (1), (1), (1), (1)
Reaktivität Human, Maus
(72), (24), (20), (6), (6), (5), (5), (5), (5), (3), (2), (2), (2), (2), (2), (1), (1)
Wirt Kaninchen
(53), (22)
Klonalität (Klon)
Polyklonal   ( )
Konjugat Dieser NR4A2 Antikörper ist unkonjugiert
(2), (1), (1), (1), (1), (1), (1), (1)
Applikation Immunofluorescence (IF), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Western Blotting (WB)
(57), (39), (24), (11), (7), (4), (3), (2), (1), (1)
Pubmed 3 Publikationen vorhanden
Hersteller

Produktdetails anti-NR4A2 Antikörper

Target Details NR4A2 Anwendungsinformationen Handhabung Referenzen für anti-NR4A2 Antikörper (ABIN390383) Bilder
Spezifität This NURR1 (NR4A2) antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 20~50 amino acids from the N-terminal region of human NURR1 (NR4A2).
Homologie Cow (Bovine),Rat (Rattus)
Reinigung This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.
Immunogen This NURR1 (NR4A2) antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 13-42 AA from the N-terminal region of human NURR1 (NR4A2).
Klon RB7385
Isotyp Ig Fraction
Plasmids, Primers & others

Target Details NR4A2

Produktdetails anti-NR4A2 Antikörper Anwendungsinformationen Handhabung Referenzen für anti-NR4A2 Antikörper (ABIN390383) Bilder zurück nach oben
Antigen
Andere Bezeichnung NURR1 (NR4A2) (NR4A2 Antibody Abstract)
Hintergrund Parkinson's disease (PD) is a multifactorial disease that appears to arise from the effects of both genetic and environmental influences. The known genetic factors include multiple genes that have been identified in related parkinsonian syndromes, as well as alpha-synuclein. Genes associated with either PD or Parkinson-related disorders include parkin, DJ-1, ubiquitin C-terminal hydrolase isozyme L1 (UCH-L1), nuclear receptor-related factor 1 (NURR1), and alpha-synuclein. Nurr1 is a transcription factor that is expressed in the embryonic ventral midbrain and is critical for the development of dopamine (DA) neurons. It belongs to the conserved family of nuclear receptors but lacks an identified ligand and is therefore referred to as an orphan receptor. RXR ligands can promote the survival of DA neurons via a process that depends on Nurr1-RXR heterodimers. In developing DA cells, Nurr1 is required for the expression of several genes important for DA synthesis and function. Nurr1 is also important for the maintenance of adult DA neurons.
Synonyms: Orphan nuclear receptor NR4A2, Orphan nuclear receptor NURR1, NURR1, NGFI-B, TINUR, NR4A2, Immediate-early response protein NOT, NOT, Transcriptionally inducible nuclear receptor
Molekulargewicht 66591 Da
Gen-ID 4929
UniProt P43354
Pathways Nuclear Receptor Transcription Pathway, Dopaminergic Neurogenesis, Steroid Hormone Mediated Signaling Pathway

Anwendungsinformationen

Produktdetails anti-NR4A2 Antikörper Target Details NR4A2 Handhabung Referenzen für anti-NR4A2 Antikörper (ABIN390383) Bilder zurück nach oben
Applikations-hinweise WB = 1:1000, IHC (p) = 1:50-100, IF = 1:10-50
Beschränkungen Nur für Forschungszwecke einsetzbar

Handhabung

Produktdetails anti-NR4A2 Antikörper Target Details NR4A2 Anwendungsinformationen Referenzen für anti-NR4A2 Antikörper (ABIN390383) Bilder zurück nach oben
Format Liquid
Konzentration 0.5 mg/mL
Buffer PBS with 0.09 % (W/V) sodium azide
Konservierungs-mittel Sodium azide
Vorsichtsmaßnahmen This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Lagerung 4 °C/-20 °C
Informationen zur Lagerung Maintain refrigerated at 2-8 °C for up to 6 months. For long term storage store at -20 °C in small aliquots to prevent freeze-thaw cycles.
Haltbarkeit 6 months

Referenzen für anti-NR4A2 Antikörper (ABIN390383)

Produktdetails anti-NR4A2 Antikörper Target Details NR4A2 Anwendungsinformationen Handhabung Bilder zurück nach oben
Produkt verwendet in:

Song, Zukor, Lin, Hascalovici, Liberman, Tavitian, Mui, Vali, Tong, Bhardwaj, Srivastava, Hamel, Schipper: "Schizophrenia-like features in transgenic mice overexpressing human HO-1 in the astrocytic compartment." in: The Journal of neuroscience : the official journal of the Society for Neuroscience, Vol. 32, Issue 32, pp. 10841-53, 2012 Von den Autoren verwendete Methode: ELISA (ELISA)

Allgemeine Veröffentlichungen

Ichinose, Ohye, Suzuki, Sumi-Ichinose, Nomura, Hagino, Nagatsu: "Molecular cloning of the human Nurr1 gene: characterization of the human gene and cDNAs." in: Gene, Vol. 230, Issue 2, pp. 233-9, 1999

Okabe, Takayanagi, Imasaki, Haji, Nawata, Watanabe: "cDNA cloning of a NGFI-B/nur77-related transcription factor from an apoptotic human T cell line." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 154, Issue 8, pp. 3871-9, 1995

Bilder

Produktdetails anti-NR4A2 Antikörper Target Details NR4A2 Anwendungsinformationen Handhabung Referenzen für anti-NR4A2 Antikörper (ABIN390383) zurück nach oben
Bilder des Herstellers
Western Blotting (WB) image for anti-Nuclear Receptor Subfamily 4, Group A, Member 2 (NR4A2) (AA 13-42), (N-Term) antibody (ABIN390383) Western blot analysis of anti-NURR1(NR4A2) Pab (ABIN390383) in mouse brain tissue lys...
Immunohistochemistry (IHC) image for anti-Nuclear Receptor Subfamily 4, Group A, Member 2 (NR4A2) (AA 13-42), (N-Term) antibody (ABIN390383) Formalin-fixed and paraffin-embedded human brain tissue reacted with NURR1 (NR4A2) an...
Immunofluorescence (IF) image for anti-Nuclear Receptor Subfamily 4, Group A, Member 2 (NR4A2) (AA 13-42), (N-Term) antibody (ABIN390383) Confocal immunofluorescent analysis of NURR1 (NR4A2) Antibody (N-term) (ABIN390383) w...