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Opn4m2 (zeige OPN4 Proteine) labeling shows nuclear localization, which did not change in response to light. opn4m1 (zeige OPN4 Proteine), opn4m2 (zeige OPN4 Proteine), gr, per1b, and cry1b presented an oscillatory profile of expression in LD condition. In both DD and LD condition, dexamethasone (DEX) treatment shifted the peak expression of per1b and cry1b transcripts
Glucocorticoid receptor positively regulates transcription of FNDC5 (zeige FNDC5 Proteine) in the liver.
Data (including data from studies in knockout/transgenic mice) suggest that, under hypoxic conditions, muscle atrophy and elevated gene expression of ubiquitin proteasomal system-associated enzymes are mostly independent of glucocorticoid/Nr3c1 signaling.
We propose that the GC-induced mitochondrial accumulation of Bax (zeige BAX Proteine) and the interaction between the GR and Bim (zeige BCL2L11 Proteine), Bcl-xL (zeige BCL2L1 Proteine) and Bak (zeige BAK1 Proteine) could play a role in the regulation of thymocyte apoptosis.
The potentiation of RANKL (zeige TNFSF11 Proteine) induced CTX release by dexamethasone was significantly less in bone marrow macrophage cells from mice with conditional knockout of the osteoclastic glucocorticoid receptor and completely absent in cells from GR(dim) mice, which carry a point mutation in one dimerizing interface of the GC receptor.
These data establish SUMO conjugation as a novel regulatory mechanism in the Hsp90 (zeige HSP90 Proteine) cochaperone activity of FKBP51 (zeige FKBP5 Proteine) with a functional impact on GR signaling in a neuronal context.
These results together suggested that ERK1 (zeige MAPK3 Proteine) phosphorylation plays a critical role in regulating GR beta expression and hydrocortisone-induce GR phosphorylation at Ser220, which is critical for the anti-apoptotic effects hydrocortisone on hepatic ischemia-reperfusion injury.
a significant protein-protein interaction between GR and CHOP (zeige DDIT3 Proteine), (GR-CHOP (zeige DDIT3 Proteine) heterocomplex formation) under endoplasmic reticulum stress conditions, is reported.
This study identifies an endocrine developmental axis in which fetal GR primes the activity of PPARalpha (zeige PPARA Proteine) in anticipation of the sudden shifts in postnatal nutrient source and metabolic demands.
Skin differentiation is impaired, and both apoptosis and cell proliferation are augmented in the absence of p23 (zeige CDK5R1 Proteine); the consequences are a severe thinning of the stratum corneum and reduced numbers of hair follicles. Since the phenotype of p23 (zeige CDK5R1 Proteine)-null embryos is strikingly similar to that of embryos lacking the glucocorticoid receptor, a paradigmatic Hsp90 (zeige HSP90 Proteine)-p23 (zeige CDK5R1 Proteine) client protein, we investigated glucocorticoid signaling.
REV-ERBalpha (zeige NR1D1 Proteine) binds to the C-terminal portion and GR to the N-terminal portion of HSP90alpha (zeige HSP90AA2 Proteine) and HSP90beta (zeige HSP90AB1 Proteine), a chaperone responsible for the activation of proteins to ensure survival of a cell.
The guinea pig GR-specific mutations within the H1-H3 loop confer global changes within the GR-Hsp90 (zeige HSP90 Proteine) complex that favor FKBP51 (zeige FKBP5 Proteine) repression over FKBP52 (zeige FKBP4 Proteine) potentiation.
Polymorphisms in NR3C1 gene is associated with sensitivity to glucocorticoids and it may contribute to the glucose abnormality for Acute Lymphoblastic Leukemia.
NR3C1 methylation moderates the effect of maternal support during stress on anxious attachment development 18 months later. More stressed children who experienced less maternal support reported increased anxious attachment when their NR3C1 gene was highly methylated. This effect could not be explained by children's level of psychopathology.
Meta-analysis showed that homozygous mutation of NR3C1 rs41423247 was associated with Depression.
This review focuses on the earlier findings on the pathophysiology of GR signaling and presents criteria facilitating identification of novel NR3C1 mutations in selected patients. [review]
The BclI NR3C1 polymorphisms were significantly associated with asthma in adults. (Meta-analysis)
Here we show genome-wide that blocked GBR generally require CHD9 and BRM (zeige SMARCA2 Proteine) for GR occupancy in contrast to GBR that are not blocked by Hic-5 (zeige TGFB1I1 Proteine). Hic-5 (zeige TGFB1I1 Proteine) blocked GBR are enriched near Hic-5 (zeige TGFB1I1 Proteine) blocked GR target genes but not near GR target genes that are not blocked by Hic-5 (zeige TGFB1I1 Proteine).
There was no significant association between different genotypes and alleles of Glucocorticoid Receptor of rs6195, rs6189/rs6190 variants, and response to fluoxetine (p=0.213 and 0.99, respectively).
NR3C1 gene polymorphisms are significantly associated with the response to glucocorticoids.
There is no clear evidence that the analysed NR3C1 allelic variants confer a risk for developing systemic autoimmune diseases although the minor G allele of rs41423247 may be protective among Caucasians (review and meta-analysis).
This study reveals the role of GR in muscle fiber inhibition on intramuscular adipocytes, and identifies myostatin (zeige MSTN Proteine) as a muscle-derived modulator for adipose GR level.
These results indicate that myostatin (zeige MSTN Proteine) mediates maternal low protein diet-induced growth retardation, through epigenetic regulation involving FoxO3 (zeige FOXO3 Proteine) and glucocorticoid receptor binding to its promoter.
Data indicate that higher hepatic glucocorticoid receptor (GR) expression in EHL piglets attributes mainly to the enhanced transcription of GR promoter 1-9/10 from breed-specific interaction of p53 (zeige TP53 Proteine) and specificity protein 1 (Sp1 (zeige SP1 Proteine)).
Tissue specificities, gene expression and induction responsiveness of the porcine NR3C1 gene.
Cloning and dna sequence analysis of the upstream flanking region of the NR3C1 gene in the domestic pig.
Effects of age, weaning and/or social isolation on the expression of genes regulating glucocorticoid response [glucocorticoid receptor).
Glucocorticoid Receptor protein expression in granulosa cells was higher in cysts from animals with spontaneous cystic ovarian disease and adrenocorticotropic hormone-induced cystic ovarian disease than in tertiary follicles from control animals.
Exposure to follicular fluid transiently increased the transcript levels of IL8 (zeige IL8 Proteine) and PTGS2 (zeige PTGS2 Proteine), and decreased the expression of SOD2 (zeige SOD2 Proteine), GPX3 (zeige GPX3 Proteine), DAB2 (zeige DAB2 Proteine), and NR3C1. TNF (zeige TNF Proteine) and IL6 (zeige IL6 Proteine) levels were also decreased while those of NAMPT (zeige NAMPT Proteine) were unaffected.
Bayesian image analysis of dexamethasone and shear stress-induced glucocorticoid receptor intracellular movement
investigation of gene expression for GR, 11HSD1, and 11HSD2 (zeige HSD11B2 Proteine) in granulosa cells and theca interna layers during follicular maturation and atresia: expression of GR was largely unchanged during follicular maturation
The E domain of the trout receptors are not involved in the nucleocytoplasmic localization of naive trout GRs (zeige GARS Proteine), but the A/B domain, especially if linked to the corresponding trout CD region, plays a pivotal role in the cellular distribution pattern.
This gene encodes glucocorticoid receptor, which can function both as a transcription factor that binds to glucocorticoid response elements in the promoters of glucocorticoid responsive genes to activate their transcription, and as a regulator of other transcription factors. This receptor is typically found in the cytoplasm, but upon ligand binding, is transported into the nucleus. It is involved in inflammatory responses, cellular proliferation, and differentiation in target tissues. Mutations in this gene are associated with generalized glucocorticoid resistance. Alternative splicing of this gene results in transcript variants encoding either the same or different isoforms. Additional isoforms resulting from the use of alternate in-frame translation initiation sites have also been described, and shown to be functional, displaying diverse cytoplasm-to-nucleus trafficking patterns and distinct transcriptional activities (PMID:15866175).
, nuclear receptor subfamily 3, group C, member 1
, glucocorticoid receptor 1
, nuclear receptor subfamily 3 group C member 1
, glucocorticoid nuclear receptor variant 1
, glucocorticoid receptor alpha
, glucocorticoid receptor variant P
, glucocorticoid receptor variant beta
, glucocorticoid receptor variant gamma