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Opn4m2 (zeige OPN4 Proteine) labeling shows nuclear localization, which did not change in response to light. opn4m1 (zeige OPN4 Proteine), opn4m2 (zeige OPN4 Proteine), gr, per1b, and cry1b presented an oscillatory profile of expression in LD condition. In both DD and LD condition, dexamethasone (DEX) treatment shifted the peak expression of per1b and cry1b transcripts
Data (including data from studies in knockout/transgenic mice) suggest that, under hypoxic conditions, muscle atrophy and elevated gene expression of ubiquitin proteasomal system-associated enzymes are mostly independent of glucocorticoid/Nr3c1 signaling.
We propose that the GC-induced mitochondrial accumulation of Bax (zeige BAX Proteine) and the interaction between the GR and Bim (zeige BCL2L11 Proteine), Bcl-xL (zeige BCL2L1 Proteine) and Bak (zeige BAK1 Proteine) could play a role in the regulation of thymocyte apoptosis.
The potentiation of RANKL (zeige TNFSF11 Proteine) induced CTX release by dexamethasone was significantly less in bone marrow macrophage cells from mice with conditional knockout of the osteoclastic glucocorticoid receptor and completely absent in cells from GR(dim) mice, which carry a point mutation in one dimerizing interface of the GC receptor.
These data establish SUMO conjugation as a novel regulatory mechanism in the Hsp90 (zeige HSP90 Proteine) cochaperone activity of FKBP51 (zeige FKBP5 Proteine) with a functional impact on GR signaling in a neuronal context.
These results together suggested that ERK1 (zeige MAPK3 Proteine) phosphorylation plays a critical role in regulating GR beta expression and hydrocortisone-induce GR phosphorylation at Ser220, which is critical for the anti-apoptotic effects hydrocortisone on hepatic ischemia-reperfusion injury.
a significant protein-protein interaction between GR and CHOP (zeige DDIT3 Proteine), (GR-CHOP (zeige DDIT3 Proteine) heterocomplex formation) under endoplasmic reticulum stress conditions, is reported.
This study identifies an endocrine developmental axis in which fetal GR primes the activity of PPARalpha (zeige PPARA Proteine) in anticipation of the sudden shifts in postnatal nutrient source and metabolic demands.
Skin differentiation is impaired, and both apoptosis and cell proliferation are augmented in the absence of p23 (zeige CDK5R1 Proteine); the consequences are a severe thinning of the stratum corneum and reduced numbers of hair follicles. Since the phenotype of p23 (zeige CDK5R1 Proteine)-null embryos is strikingly similar to that of embryos lacking the glucocorticoid receptor, a paradigmatic Hsp90 (zeige HSP90 Proteine)-p23 (zeige CDK5R1 Proteine) client protein, we investigated glucocorticoid signaling.
REV-ERBalpha (zeige NR1D1 Proteine) binds to the C-terminal portion and GR to the N-terminal portion of HSP90alpha (zeige HSP90AA2 Proteine) and HSP90beta (zeige HSP90AB1 Proteine), a chaperone responsible for the activation of proteins to ensure survival of a cell.
Phospho-AMPK (zeige PRKAA1 Proteine) is a molecular switch able to cooperate with glucocorticoid receptors and Ppar-alpha (zeige PPARA Proteine) at the chromatin level, a novel adaptation mechanism to prolonged fasting.
The guinea pig GR-specific mutations within the H1-H3 loop confer global changes within the GR-Hsp90 (zeige HSP90 Proteine) complex that favor FKBP51 (zeige FKBP5 Proteine) repression over FKBP52 (zeige FKBP4 Proteine) potentiation.
Here we show genome-wide that blocked GBR generally require CHD9 and BRM (zeige SMARCA2 Proteine) for GR occupancy in contrast to GBR that are not blocked by Hic-5 (zeige TGFB1I1 Proteine). Hic-5 (zeige TGFB1I1 Proteine) blocked GBR are enriched near Hic-5 (zeige TGFB1I1 Proteine) blocked GR target genes but not near GR target genes that are not blocked by Hic-5 (zeige TGFB1I1 Proteine).
There was no significant association between different genotypes and alleles of Glucocorticoid Receptor of rs6195, rs6189/rs6190 variants, and response to fluoxetine (p=0.213 and 0.99, respectively).
NR3C1 gene polymorphisms are significantly associated with the response to glucocorticoids.
There is no clear evidence that the analysed NR3C1 allelic variants confer a risk for developing systemic autoimmune diseases although the minor G allele of rs41423247 may be protective among Caucasians (review and meta-analysis).
Analyses demonstrated a trend in the association between maternal trait anxiety and depression symptoms with placental gene expression of NR3C1. We found a significant interaction with maternal ethnicity. In Caucasians only, prenatal trait anxiety and depressive symptoms were associated with an increase in placental NR3C1 expression, and prenatal life events were associated with a down regulation of HSD11B2 (zeige HSD11B2 Proteine)
We genotyped 10 single nucleotide polymorphisms (SNPs) on the NR3C1 gene (rs10482682, rs33389, rs10482633, rs10515522, rs2963156, rs4128428, rs9324918, rs41423247, rs6189, rs10052957).Haplotype analyses revealed significant effects of NR3C1 (p = 0.011) on cortisol stress response. Neither NR3C1 haplotype nor NR3C2 (zeige NR3C2 Proteine) haplotype was associated with reasoning abilities.
In this study, we described the cellular localization of the glucocorticoid receptor in the human adult and fetal testis and provided evidence of an association between semen quality and a genetic polymorphism BclI (rs41423247) in the NR3C1 gene.
Results indicate that maltreated children evidence higher baseline levels of NR3C1 methylation, significant decreases in methylation over time, and then at follow-up, lower levels of methylation, relative to nonmaltreated preschoolers.
children with early onset maltreatment evidence significant hypermethylation compared to nonmaltreated children. Also, hypermethylation of NR3C1 is linked with a number of negative child outcomes including greater emotional lability-negativity, higher levels of ego undercontrol, more externalizing behavior, and greater depressive symptoms.
Study evaluated whether associations between early adversity and brain responses to dynamic facial expressions in early adulthood varied as a function of regional differences in the expression of NR3C1. Strongest associations between adversities and BOLD response to fearful faces were in brain regions with higher NR3C1 mRNA expression levels. Highest expression of NR3C1 is found in occipital and lowest in temporal regions
This study reveals the role of GR in muscle fiber inhibition on intramuscular adipocytes, and identifies myostatin (zeige MSTN Proteine) as a muscle-derived modulator for adipose GR level.
These results indicate that myostatin (zeige MSTN Proteine) mediates maternal low protein diet-induced growth retardation, through epigenetic regulation involving FoxO3 (zeige FOXO3 Proteine) and glucocorticoid receptor binding to its promoter.
Data indicate that higher hepatic glucocorticoid receptor (GR) expression in EHL piglets attributes mainly to the enhanced transcription of GR promoter 1-9/10 from breed-specific interaction of p53 (zeige TP53 Proteine) and specificity protein 1 (Sp1 (zeige SP1 Proteine)).
Tissue specificities, gene expression and induction responsiveness of the porcine NR3C1 gene.
Cloning and dna sequence analysis of the upstream flanking region of the NR3C1 gene in the domestic pig.
Effects of age, weaning and/or social isolation on the expression of genes regulating glucocorticoid response [glucocorticoid receptor).
Glucocorticoid Receptor protein expression in granulosa cells was higher in cysts from animals with spontaneous cystic ovarian disease and adrenocorticotropic hormone-induced cystic ovarian disease than in tertiary follicles from control animals.
Exposure to follicular fluid transiently increased the transcript levels of IL8 (zeige IL8 Proteine) and PTGS2 (zeige PTGS2 Proteine), and decreased the expression of SOD2 (zeige SOD2 Proteine), GPX3 (zeige GPX3 Proteine), DAB2 (zeige DAB2 Proteine), and NR3C1. TNF (zeige TNF Proteine) and IL6 (zeige IL6 Proteine) levels were also decreased while those of NAMPT (zeige NAMPT Proteine) were unaffected.
Bayesian image analysis of dexamethasone and shear stress-induced glucocorticoid receptor intracellular movement
investigation of gene expression for GR, 11HSD1, and 11HSD2 (zeige HSD11B2 Proteine) in granulosa cells and theca interna layers during follicular maturation and atresia: expression of GR was largely unchanged during follicular maturation
The E domain of the trout receptors are not involved in the nucleocytoplasmic localization of naive trout GRs (zeige GARS Proteine), but the A/B domain, especially if linked to the corresponding trout CD region, plays a pivotal role in the cellular distribution pattern.
This gene encodes glucocorticoid receptor, which can function both as a transcription factor that binds to glucocorticoid response elements in the promoters of glucocorticoid responsive genes to activate their transcription, and as a regulator of other transcription factors. This receptor is typically found in the cytoplasm, but upon ligand binding, is transported into the nucleus. It is involved in inflammatory responses, cellular proliferation, and differentiation in target tissues. Mutations in this gene are associated with generalized glucocorticoid resistance. Alternative splicing of this gene results in transcript variants encoding either the same or different isoforms. Additional isoforms resulting from the use of alternate in-frame translation initiation sites have also been described, and shown to be functional, displaying diverse cytoplasm-to-nucleus trafficking patterns and distinct transcriptional activities (PMID:15866175).
, nuclear receptor subfamily 3, group C, member 1
, glucocorticoid receptor 1
, nuclear receptor subfamily 3 group C member 1
, glucocorticoid nuclear receptor variant 1
, glucocorticoid receptor alpha
, glucocorticoid receptor variant P
, glucocorticoid receptor variant beta
, glucocorticoid receptor variant gamma