anti-Schwein Nuclear Receptor Subfamily 1, Group I, Member 2 Antikörper für Western Blotting
Recommended Nuclear Receptor Subfamily 1, Group I, Member 2 Antibody
- Antigen
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Nuclear Receptor Subfamily 1, Group I, Member 2 (NR1I2) Antikörper
Synonyme für dieses Antigen anzeigen- BXR
- ONR1
- PAR
- PAR1
- PAR2
- PARq
- PRR
- PXR
- SAR
- SXR
- PXR.1
- PXR.2
- PXR1
- mPXR
- bxr
- nr1i2
- onr1
- xonr1
- nuclear receptor subfamily 1 group I member 2
- nuclear receptor subfamily 1, group I, member 2
- nuclear receptor subfamily 1 group I member 2 S homeolog
- NR1I2
- Nr1i2
- nr1i2.S
- nr1i2
- Epitop
-
C-Term
Alternativen - Reaktivität
-
Rind (Kuh), Hund, Meerschweinchen, Pferd, Human, Maus, Schwein, Kaninchen, Ratte (Rattus)
Alternativen - Wirt
-
Kaninchen
Alternativen - Klonalität
- Konjugat
-
Unkonjugiert
Alternativen - Applikation
-
Western Blotting (WB)
Alternativen - Optionen
Produktnummer ABIN2781173
$ 249.00
Zzgl. Versandkosten $45.00
Zzgl. Versandkosten $45.00
Relevance Score | ABIN | Application | Konjugat | Host | Isotype | Epitope | Clonality | References | Details |
---|---|---|---|---|---|---|---|---|---|
4 | ABIN203170 | WB | Rabbit | IgG | C-Term | Polyclonal | 0 |
General |
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Antigen | Nuclear Receptor Subfamily 1, Group I, Member 2 (NR1I2) Antikörper |
Epitop | C-Term Alternativen |
Reaktivität | Rind (Kuh), Hund, Meerschweinchen, Pferd, Human, Maus, Schwein, Kaninchen, Ratte (Rattus) Alternativen |
Wirt | Kaninchen Alternativen |
Klonalität | |
Konjugat | Unkonjugiert Alternativen |
Applikation |
Western Blotting (WB)
Alternativen
|
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1 Publikation vorhanden |
Hersteller | |
ProduktdetailsAntigendetails Anwendungsinformationen Handhabung Referenzen Bilder |
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Sequenz | PQPAHRFLFL KIMAMLTELR SINAQHTQRL LRIQDIHPFA TPLMQELFGI |
Homologie | Cow: 77%, Dog: 100%, Guinea Pig: 85%, Horse: 93%, Human: 100%, Mouse: 92%, Pig: 100%, Rabbit: 93%, Rat: 92% |
Produktmerkmale | This is a rabbit polyclonal antibody against NR1I2. It was validated on Western Blot using a cell lysate as a positive control. |
Reinigung | Protein A purified |
Immunogen | The immunogen is a synthetic peptide directed towards the C terminal region of human NR1I2 |
AntigendetailsProduktdetails Anwendungsinformationen Handhabung Referenzen Bilder zurück nach oben |
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Antigen | |
Andere Bezeichnung | NR1I2 (NR1I2 Antibody Abstract) |
Hintergrund |
NR1I2 belongs to the nuclear receptor superfamily, members of which are transcription factors characterized by a ligand-binding domain and a DNA-binding domain. NR1I2 contains a zinc finger domain.NR1I2 is a transcriptional regulator of the cytochrome P450 gene CYP3A4, binding to the response element of the CYP3A4 promoter as a heterodimer with the 9-cis retinoic acid receptor RXR. It is activated by a range of compounds that induce CYP3A4, including dexamethasone and rifampicin. The gene product belongs to the nuclear receptor superfamily, members of which are transcription factors characterized by a ligand-binding domain and a DNA-binding domain. The encoded protein is a transcriptional regulator of the cytochrome P450 gene CYP3A4, binding to the response element of the CYP3A4 promoter as a heterodimer with the 9-cis retinoic acid receptor RXR. It is activated by a range of compounds that induce CYP3A4, including dexamethasone and rifampicin. The gene product contains a zinc finger domain. Three alternatively spliced transcripts that encode different isoforms have been described, one of which encodes two products through the use of alternative translation initiation codons. Additional transcript variants derived from alternative promoter usage, alternative splicing, and/or alternative polyadenylation exist, but they have not been fully described. Alias Symbols: BXR, PAR, PRR, PXR, SAR, SXR, ONR1, PAR1, PAR2, PARq Protein Interaction Partner: NCOA1, RPS6KB1, UBC, RBBP7, DDB1, UBR5, DYRK2, NCOR2, SDF4, NCOA3, TFAP2C, MAPK7, NFATC4, HSP90AA1, FGR, ATP6AP1, RXRA, RBCK1, NCOA2, SUMO1, SUMO2, SUMO3, NCOA6, SRC, RXRG, RXRB, CHMP1A, NUCB2, ACTN2, PPARGC1A, EIF3I, TADA3, NCOR1, PRMT1, NR1I2, PSMC5, PO Protein Size: 473 |
Molekulargewicht | 54 kDa |
Gen-ID | 8856 |
NCBI Accession | NM_022002, NP_071285 |
UniProt | Q9UNW4 |
Pathways | Nuclear Receptor Transcription Pathway, Steroid Hormone Mediated Signaling Pathway |
AnwendungsinformationenProduktdetails Antigendetails Handhabung Referenzen Bilder zurück nach oben |
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Applikations-hinweise | Optimal working dilutions should be determined experimentally by the investigator. |
Kommentare |
Antigen size: 473 AA |
Beschränkungen | Nur für Forschungszwecke einsetzbar |
HandhabungProduktdetails Antigendetails Anwendungsinformationen Referenzen Bilder zurück nach oben |
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Format | Liquid |
Konzentration | Lot specific |
Buffer | Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose. |
Konservierungs-mittel | Sodium azide |
Vorsichtsmaßnahmen | This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only. |
Handhabung | Avoid repeated freeze-thaw cycles. |
Lagerung | -20 °C |
Informationen zur Lagerung | For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles. |
ReferenzenProduktdetails Antigendetails Anwendungsinformationen Handhabung Bilder zurück nach oben |
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Allgemeine Veröffentlichungen |
Dring, Goulding, Trimble, Keegan, Ryan, Brophy, Smyth, Keeling, ODonoghue, OSullivan, OMorain, Mahmud, Wikström, Kelleher, McManus: "The pregnane X receptor locus is associated with susceptibility to inflammatory bowel disease." in: Gastroenterology, Vol. 130, Issue 2, pp. 341-8; quiz 592, 2006 |
BilderProduktdetails Antigendetails Anwendungsinformationen Handhabung Referenzen zurück nach oben |
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Bilder des Herstellers |