anti-Hund Nuclear Receptor Subfamily 1, Group I, Member 2 Antikörper für Western Blotting

Recommended Nuclear Receptor Subfamily 1, Group I, Member 2 Antibody

Antigen
Nuclear Receptor Subfamily 1, Group I, Member 2 (NR1I2) Antikörper
  • BXR
  • ONR1
  • PAR
  • PAR1
  • PAR2
  • PARq
  • PRR
  • PXR
  • SAR
  • SXR
  • PXR.1
  • PXR.2
  • PXR1
  • mPXR
  • bxr
  • nr1i2
  • onr1
  • xonr1
  • nuclear receptor subfamily 1 group I member 2
  • nuclear receptor subfamily 1, group I, member 2
  • nuclear receptor subfamily 1 group I member 2 S homeolog
  • NR1I2
  • Nr1i2
  • nr1i2.S
  • nr1i2
Epitop
C-Term
15
15
11
11
9
9
7
6
6
5
2
2
2
1
1
1
1
1
1
1
1
1
Reaktivität
Rind (Kuh), Hund, Meerschweinchen, Pferd, Human, Maus, Schwein, Kaninchen, Ratte (Rattus)
138
58
57
1
1
1
1
1
1
1
Wirt
Kaninchen
121
21
14
Klonalität
Polyklonal
Konjugat
Unkonjugiert
10
9
5
3
3
3
3
3
3
3
3
3
2
2
2
2
2
Applikation
Western Blotting (WB)
120
60
37
26
18
13
11
10
9
8
2
2
Optionen

Bilder

Produktnummer ABIN2781173
$ 249.00
Zzgl. Versandkosten $45.00
Relevance Score ABIN Application Konjugat Host Isotype Epitope Clonality References Details
4 ABIN203170 WB Rabbit IgG C-Term Polyclonal 0

General

Antigen Nuclear Receptor Subfamily 1, Group I, Member 2 (NR1I2) Antikörper
Epitop C-Term
(15), (15), (11), (11), (9), (9), (7), (6), (6), (5), (2), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Reaktivität Rind (Kuh), Hund, Meerschweinchen, Pferd, Human, Maus, Schwein, Kaninchen, Ratte (Rattus)
(138), (58), (57), (1), (1), (1), (1), (1), (1), (1)
Wirt Kaninchen
(121), (21), (14)
Klonalität
Polyklonal
Konjugat Unkonjugiert
(10), (9), (5), (3), (3), (3), (3), (3), (3), (3), (3), (3), (2), (2), (2), (2), (2)
Applikation Western Blotting (WB)
(120), (60), (37), (26), (18), (13), (11), (10), (9), (8), (2), (2)
Pubmed 1 Publikation vorhanden
Hersteller

Produktdetails

Antigendetails Anwendungsinformationen Handhabung Referenzen Bilder
Sequenz PQPAHRFLFL KIMAMLTELR SINAQHTQRL LRIQDIHPFA TPLMQELFGI
Homologie Cow: 77%, Dog: 100%, Guinea Pig: 85%, Horse: 93%, Human: 100%, Mouse: 92%, Pig: 100%, Rabbit: 93%, Rat: 92%
Produktmerkmale This is a rabbit polyclonal antibody against NR1I2. It was validated on Western Blot using a cell lysate as a positive control.
Reinigung Protein A purified
Immunogen The immunogen is a synthetic peptide directed towards the C terminal region of human NR1I2

Antigendetails

Produktdetails Anwendungsinformationen Handhabung Referenzen Bilder zurück nach oben
Antigen
Andere Bezeichnung NR1I2 (NR1I2 Antibody Abstract)
Hintergrund NR1I2 belongs to the nuclear receptor superfamily, members of which are transcription factors characterized by a ligand-binding domain and a DNA-binding domain. NR1I2 contains a zinc finger domain.NR1I2 is a transcriptional regulator of the cytochrome P450 gene CYP3A4, binding to the response element of the CYP3A4 promoter as a heterodimer with the 9-cis retinoic acid receptor RXR. It is activated by a range of compounds that induce CYP3A4, including dexamethasone and rifampicin. The gene product belongs to the nuclear receptor superfamily, members of which are transcription factors characterized by a ligand-binding domain and a DNA-binding domain. The encoded protein is a transcriptional regulator of the cytochrome P450 gene CYP3A4, binding to the response element of the CYP3A4 promoter as a heterodimer with the 9-cis retinoic acid receptor RXR. It is activated by a range of compounds that induce CYP3A4, including dexamethasone and rifampicin. The gene product contains a zinc finger domain. Three alternatively spliced transcripts that encode different isoforms have been described, one of which encodes two products through the use of alternative translation initiation codons. Additional transcript variants derived from alternative promoter usage, alternative splicing, and/or alternative polyadenylation exist, but they have not been fully described.
Alias Symbols: BXR, PAR, PRR, PXR, SAR, SXR, ONR1, PAR1, PAR2, PARq
Protein Interaction Partner: NCOA1, RPS6KB1, UBC, RBBP7, DDB1, UBR5, DYRK2, NCOR2, SDF4, NCOA3, TFAP2C, MAPK7, NFATC4, HSP90AA1, FGR, ATP6AP1, RXRA, RBCK1, NCOA2, SUMO1, SUMO2, SUMO3, NCOA6, SRC, RXRG, RXRB, CHMP1A, NUCB2, ACTN2, PPARGC1A, EIF3I, TADA3, NCOR1, PRMT1, NR1I2, PSMC5, PO
Protein Size: 473
Molekulargewicht 54 kDa
Gen-ID 8856
NCBI Accession NM_022002, NP_071285
UniProt Q9UNW4
Pathways Nuclear Receptor Transcription Pathway, Steroid Hormone Mediated Signaling Pathway

Anwendungsinformationen

Produktdetails Antigendetails Handhabung Referenzen Bilder zurück nach oben
Applikations-hinweise Optimal working dilutions should be determined experimentally by the investigator.
Kommentare

Antigen size: 473 AA

Beschränkungen Nur für Forschungszwecke einsetzbar

Handhabung

Produktdetails Antigendetails Anwendungsinformationen Referenzen Bilder zurück nach oben
Format Liquid
Konzentration Lot specific
Buffer Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.
Konservierungs-mittel Sodium azide
Vorsichtsmaßnahmen This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Handhabung Avoid repeated freeze-thaw cycles.
Lagerung -20 °C
Informationen zur Lagerung For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Referenzen

Produktdetails Antigendetails Anwendungsinformationen Handhabung Bilder zurück nach oben
Allgemeine Veröffentlichungen

Dring, Goulding, Trimble, Keegan, Ryan, Brophy, Smyth, Keeling, ODonoghue, OSullivan, OMorain, Mahmud, Wikström, Kelleher, McManus: "The pregnane X receptor locus is associated with susceptibility to inflammatory bowel disease." in: Gastroenterology, Vol. 130, Issue 2, pp. 341-8; quiz 592, 2006

Bilder

Produktdetails Antigendetails Anwendungsinformationen Handhabung Referenzen zurück nach oben
Bilder des Herstellers
Western Blotting (WB) image for anti-Nuclear Receptor Subfamily 1, Group I, Member 2 (NR1I2) (C-Term) antibody (ABIN2781173) WB Suggested Anti-NR1I2 Antibody Titration: 5.0ug/ml ELISA Titer: 1:12500 Positiv...