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Human Polyclonal NR1H2/3 Primary Antibody für ELISA, WB - ABIN250297
Tangirala, Bischoff, Joseph, Wagner, Walczak, Laffitte, Daige, Thomas, Heyman, Mangelsdorf, Wang, Lusis, Tontonoz, Schulman: Identification of macrophage liver X receptors as inhibitors of atherosclerosis. in Proceedings of the National Academy of Sciences of the United States of America 2002
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LXR (zeige NR1H3 Antikörper) gene expression was significantly increased in obese children with obstructive sleep apnea-hypopnea syndrome (OSAHS). The severity of OSAHS was positively correlated with COX-2 (zeige COX2 Antikörper) levels.
In conclusion, the present study demonstrated that activation of LXRalpha-ABCA1 axis with a synthetic LXR agonist TO90 exerted a potent protective effect against Abeta induced senescent and inflammatory responses in retinal pigment epithelial cells, suggesting that LXR agonists may be promising therapeutic agents for treating age-related macular degeneration.
AMPK (zeige PRKAA1 Antikörper) activates LXRalpha (zeige NR1H3 Antikörper) and ABCA1 (zeige ABCA1 Antikörper) expression in human macrophages
PPARalpha (zeige PPARA Antikörper) and LXRalpha (zeige NR1H3 Antikörper) may be mediators by which omega3PUFA attenuate bile acid-induced hepatocellular injury
Inhibition of Pancreatic Cancer Cell-Induced Paracrine Hedgehog Signaling by Liver X Receptor Agonists and Oxy16, a Naturally Occurring Oxysterol
Data identify LXR as an important factor in early-pregnancy lipogenesis that is also necessary to protect against abnormalities in fetoplacental lipid homeostasis.
data suggest that ASXL3 is another corepressor of LXRalpha (zeige NR1H3 Antikörper), promoting to the regulation of lipid homeostasis
results indicated that LXRalpha (zeige NR1H3 Antikörper) plays a specific and important role in activation of TH by regulating D1, and that LXRalpha (zeige NR1H3 Antikörper) binds to and regulates the hDIO1 promoter, competing with TRbeta (zeige TXNRD2 Antikörper) on specific sequences within the promoter.
GW3965 significantly increases the expression of liver X nuclear receptor beta (zeige NR1H2 Antikörper) (LXRbeta (zeige NR1H2 Antikörper)) mRNA, while the liver X nuclear receptor alpha (LXRalpha (zeige NR1H3 Antikörper)( mRNA expression did not change a lot, and sensitizes gefitinib by inhibiting NF-kappa B (NF-kappaB (zeige NFKB1 Antikörper)) activation.
Transactivation assays showed that MCFA activated LXRa, whereas long-chain FA caused no effect. Our results suggest that LXRa functions as a receptor for saturated FA or acyl-CoA of C10 and C12 in length.
The protein encoded by this gene belongs to the NR1 subfamily of the nuclear receptor superfamily. The NR1 family members are key regulators of macrophage function, controlling transcriptional programs involved in lipid homeostasis and inflammation. This protein is highly expressed in visceral organs, including liver, kidney and intestine. It forms a heterodimer with retinoid X receptor (RXR), and regulates expression of target genes containing retinoid response elements. Studies in mice lacking this gene suggest that it may play an important role in the regulation of cholesterol homeostasis. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.
liver X nuclear receptor alpha variant 1
, oxysterols receptor LXR-alpha