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Human Polyclonal NR1H2/3 Primary Antibody für ELISA, WB - ABIN250297
Tangirala, Bischoff, Joseph, Wagner, Walczak, Laffitte, Daige, Thomas, Heyman, Mangelsdorf, Wang, Lusis, Tontonoz, Schulman: Identification of macrophage liver X receptors as inhibitors of atherosclerosis. in Proceedings of the National Academy of Sciences of the United States of America 2002
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In patients with systemic lupus erythematosus carrying LXRA 1830 T > C polymorphism, LXRA expression increased in macrophages; and levels of proinflammatory cytokines decreased with LXRA expression. Expression of LXRA was decreased and that of proinflammatory cytokines was increased for LXRA -1830 TC genotype compared to that for TT genotype.
LXRalpha activation antagonizes the mesenchymal, reactive oxygen species and pro-apoptotic responses to TGFbeta and the mesenchymal transcription factor Snail mediates this crosstalk. In contrast, LXRalpha activation and TGFbeta cooperate in enforcing cytostasis in HCC, which preserves their epithelial features.
Large-scale multiple sclerosis (MS) genome-wide association studies with a total of 27,148 samples including 9772 MS cases and 17,376 controls, and multiple expression quantitative trait loci datasets. The results suggest that rs7120118 and rs2279238 variants are significantly associated with MS risk, and could significantly regulate NR1H3 expression in kinds of human tissues and cells.
ENHO, RXRA, and LXRA polymorphisms and dyslipidemia, related comorbidities and survival in hemodialysis patients have been reported.
we found that siphonaxanthin (SPX), blocked LXR-alpha activation and would be a promising candidate for antagonist of LXR-alpha .
The authors report that, in Mycobacterium tuberculosis-infected macrophages, IL-36 signaling modulates cholesterol biosynthesis and efflux via LXR.
LXR-alpha played a central role in down-regulating of ABCA1 and ABCG1 and lipid accumulation induced by homocysteine in the macrophages.
LXRalpha interacts with OGT in its N-terminal domain and ligand-binding domain (LBD) in a ligand-independent fashion.
Our data suggest that LXR could be used as a biomarker for hepatocellular carcinoma prognosis.
PBMCs from healthy persons were predisposed to the MPhi2 differentiation phenotype, which exhibits elevated cholesterol uptake and anti-inflammatory properties. LXRalpha over-expression polarizes macrophages towards the anti-inflammatory MPhi2 phenotype.
LXR gene expression was significantly increased in obese children with obstructive sleep apnea-hypopnea syndrome (OSAHS). The severity of OSAHS was positively correlated with COX-2 levels.
In conclusion, the present study demonstrated that activation of LXRalpha-ABCA1 axis with a synthetic LXR agonist TO90 exerted a potent protective effect against Abeta induced senescent and inflammatory responses in retinal pigment epithelial cells, suggesting that LXR agonists may be promising therapeutic agents for treating age-related macular degeneration.
AMPK activates LXRalpha and ABCA1 expression in human macrophages
PPARalpha and LXRalpha may be mediators by which omega3PUFA attenuate bile acid-induced hepatocellular injury
Inhibition of Pancreatic Cancer Cell-Induced Paracrine Hedgehog Signaling by Liver X Receptor Agonists and Oxy16, a Naturally Occurring Oxysterol
Data identify LXR as an important factor in early-pregnancy lipogenesis that is also necessary to protect against abnormalities in fetoplacental lipid homeostasis.
data suggest that ASXL3 is another corepressor of LXRalpha, promoting to the regulation of lipid homeostasis
results indicated that LXRalpha plays a specific and important role in activation of TH by regulating D1, and that LXRalpha binds to and regulates the hDIO1 promoter, competing with TRbeta on specific sequences within the promoter.
GW3965 significantly increases the expression of liver X nuclear receptor beta (LXRbeta) mRNA, while the liver X nuclear receptor alpha (LXRalpha( mRNA expression did not change a lot, and sensitizes gefitinib by inhibiting NF-kappa B (NF-kappaB) activation.
Transactivation assays showed that MCFA activated LXRa, whereas long-chain FA caused no effect. Our results suggest that LXRa functions as a receptor for saturated FA or acyl-CoA of C10 and C12 in length.
The protein encoded by this gene belongs to the NR1 subfamily of the nuclear receptor superfamily. The NR1 family members are key regulators of macrophage function, controlling transcriptional programs involved in lipid homeostasis and inflammation. This protein is highly expressed in visceral organs, including liver, kidney and intestine. It forms a heterodimer with retinoid X receptor (RXR), and regulates expression of target genes containing retinoid response elements. Studies in mice lacking this gene suggest that it may play an important role in the regulation of cholesterol homeostasis. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.
liver X nuclear receptor alpha variant 1
, oxysterols receptor LXR-alpha