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Hamster Polyclonal NR0B2 Primary Antibody für IHC (p) - ABIN271164
He, Park, Zhang, Huang, Lu, Wang: Epigenetic inhibition of nuclear receptor small heterodimer partner is associated with and regulates hepatocellular carcinoma growth. in Gastroenterology 2008
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Data indicate a functional interaction between small heterodimer partner protein SHP1 and hepatitis C virus (HCV) NS5A protein.
This study was performed to test the hypothesis that the SHP (zeige LAMC1 Antikörper) gene is a target gene of DEC1 (zeige BHLHE40 Antikörper). Cotransfection demonstrated that DEC1 (zeige BHLHE40 Antikörper) repressed the SHP (zeige LAMC1 Antikörper) promoter and attenuated the transactivation of the classic circadian activator complex of Clock/Bmal1 (zeige ARNTL Antikörper).
The molecular dynamics and structural analysis of the small heterodimer partner in complex with glucocorticoid receptor (zeige NR3C1 Antikörper) is described.
The finding that overexpression of HIF-1alpha (zeige HIF1A Antikörper) increased the activity of the CYP7A1 (zeige CYP7A1 Antikörper) promoter suggested that hypoxia decreased the expression of CYP7A1 (zeige CYP7A1 Antikörper) in a HIF-1 (zeige HIF1A Antikörper)-independent manner.
Results demonstrated a detrimental effect of Bcl2 (zeige BCL2 Antikörper) and H19 (zeige NCKAP1 Antikörper) associated with cholestatic liver fibrosis and an indispensable role of Shp (zeige LAMC1 Antikörper) to maintain normal liver function.
These findings show that POD-1/TCF21 (zeige TCF21 Antikörper) regulates SF-1 (zeige NR5A1 Antikörper) and LRH-1 (zeige NR5A2 Antikörper) by distinct mechanisms, contributing to the understanding of POD-1 (zeige TCF21 Antikörper) involvement and its mechanisms of action in adrenal and liver tumorigenesis.
Overexpression of SHP (zeige LAMC1 Antikörper) and activation of AMPK (zeige PRKAA1 Antikörper) reverses profibrogenic features of HCV-infected cells by decreasing TGF-beta (zeige TGFB1 Antikörper) and fibrotic gene expression.
Data suggest that LRH1/NR5A2 (zeige NR5A2 Antikörper) (liver receptor homologue-1) exhibits phospholipid-mediated allosteric control of protein-protein binding interface in interactions with TIF2 (zeige NCOA2 Antikörper) (co-activator; transcription intermediary factor 2) and SHP (zeige LAMC1 Antikörper).
At the molecular level, estrogen upregulated hepatic SHP (zeige LAMC1 Antikörper) expression through binding to its proximal promoter. In addition, the roles of estrogen were largely blunted in mice with SHP (zeige LAMC1 Antikörper) deficiency.
These data are suggestive of a role for SHP (zeige LAMC1 Antikörper) in controlling NLRP3 (zeige NLRP3 Antikörper) inflammasome activation through a mechanism involving interaction with NLRP3 (zeige NLRP3 Antikörper) and maintenance of mitochondrial homeostasis.
Six novel SNPs, five in ME1 (zeige ME1 Antikörper) and one in NR0B2, were identified as candidates that have effects on meat and carcass quality traits.
Data confirm that hepatic stellate cell activation and alteration in hepatic gene expression observed in offspring of dames on vitamin A-deficient diet from mid-gestation are dependent on retinol and Shp/Nr0b2; these alterations in the offspring are reversed by high-fat diet.
SHP (zeige LAMC1 Antikörper) deficiency protects myocardia from lipid accumulation in high fat diet-fed mice.
human microbiota was able to reduce the levels of tauro-beta-muricholic acid and induce expression of FXR (zeige NR1H4 Antikörper) target genes Fgf15 and Shp (zeige LAMC1 Antikörper) in ileum after long-term colonization. We show that a human microbiota can change BA composition and induce FXR (zeige NR1H4 Antikörper) signaling in colonized mice, but the levels of secondary BAs produced are lower than in mice colonized with a mouse microbiota
SHP (zeige LAMC1 Antikörper) and REV-ERBalpha (zeige NR1D1 Antikörper) play a critical role in controlling rhythmic CHOP (zeige DDIT3 Antikörper) expression in alcoholic fatty liver
our results suggest that SHP (zeige LAMC1 Antikörper) upregulation upon high-fat feeding leads to lipid accumulation, insulin (zeige INS Antikörper) resistance and inflammation in cardiomyocytes.
Mortality of SHP (zeige LAMC1 Antikörper)-/- mice after ethanol binge feeding was significantly reduced and Aldh2 (zeige ALDH2 Antikörper) mRNA level was higher. After an intoxicating dose of ethanol, SHP (zeige LAMC1 Antikörper)-/- mice exhibited faster blood ethanol clearance.
This study reveals SHP (zeige LAMC1 Antikörper) as a global transcriptional partner of SREBP-2 (zeige SREBF2 Antikörper) in regulation of sterol biosynthetic gene networks and provides a potential mechanism for cholesterol-lowering action of FGF19 (zeige FGF19 Antikörper).
Our results suggest that SHP (zeige LAMC1 Antikörper) is required for both antidiabetic and hypolipidemic effects of TZDs in ob/ob mice through regulation of PPARgamma (zeige PPARG Antikörper) expression.
LSD1 (zeige KDM1A Antikörper) is a novel histone-modifying enzyme in the orchestrated regulation mediated by the farnesoid X receptor (zeige xpr1 Antikörper) and small heterodimer partner that reduces hepatic bile acid levels and protects the liver against bile acid toxicity.
The protein encoded by this gene is an unusual orphan receptor that contains a putative ligand-binding domain but lacks a conventional DNA-binding domain. The gene product is a member of the nuclear hormone receptor family, a group of transcription factors regulated by small hydrophobic hormones, a subset of which do not have known ligands and are referred to as orphan nuclear receptors. The protein has been shown to interact with retinoid and thyroid hormone receptors, inhibiting their ligand-dependent transcriptional activation. In addition, interaction with estrogen receptors has been demonstrated, leading to inhibition of function. Studies suggest that the protein represses nuclear hormone receptor-mediated transactivation via two separate steps: competition with coactivators and the direct effects of its transcriptional repressor function.
short heterodimer partner
, nuclear receptor subfamily 0 group B member 2
, nuclear receptor SHP
, orphan nuclear receptor SHP
, small heterodimer partner
, small heterodimer partner homologue