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The expressions of survivin and STAT2 (zeige STAT2 Proteine) are up-regulated in skin lesions of PV patients, and their mRNA expressions are positively correlated.
Findings suggest that lysosome-associated transmembrane protein 4B (LAPTM4B), vascular endothelial growth factor (VEGF (zeige VEGF Proteine)), and nuclear survivin expression are significantly correlated in breast cancer, which may be predictive of prognosis as well as effective therapeutic targets for anticancer therapies.
HIF-2alpha (zeige EPAS1 Proteine) dictates the resistance of human pancreatic cancer cells to TRAIL under normoxic and hypoxic conditions and transcriptionally regulates survivin expression.
survivin may have a role in recurrence in rectal cancer patients treated with surgery and postoperative concurrent chemo-radiation therapy
Results identified BIRC5 to be significantly upregulated in the lung squamous cell carcinoma tissues of smoking patients and may play an important role in diagnosis and prognosis.
After cancer cell fusion, some fused cells avoid the apoptotic crisis partly owing to survivin, and continue to proliferate, a process that contributes to human cancer progression.
High survivin expression is associated with lung cancer and colorectal cancer.
Data suggest that Ki-67 (zeige MKI67 Proteine) index and survivin may be useful biomarkers for rectal cancer with preoperative chemoradiotherapy.
In gastroenteropancreatic neuroendocrine neoplasms survivin and XIAP (zeige XIAP Proteine) regulate cell proliferation and apoptosis functioning as possible prognostic biomarkers and therapeutic targets.
inhibition of apoptosis targeting survivin might represent an effective strategy for both obesity and cancer therapy.
While induced by exposure to reactive oxygen species generating stresses, the ultimate expression of changes in radiation response is dependent upon the bi-functionality of the tumor associated protein survivin and its intracellular translocation.
HDL (zeige HSD11B1 Proteine)-associated sphingosine 1-phosphate inhibits macrophage apoptosis by stimulating STAT3 (zeige STAT3 Proteine) activity and survivin expression.
Survivin also attenuates DNA damage related to PARP (zeige PARP1 Proteine) activation and inhibits TNFalpha (zeige TNF Proteine)-induced lipolysis, suggesting that Survivin may facilitate adipocyte maintenance in response to inflammatory stimuli.
The study assigns a new meiotic function to Cullin9 and reveals that it prevents mouse eggs from aneuploidy by regulating microtubule dynamics via survivin.
this study shows that that sorafenib promotes the survival of bone marrow cells by up-regulating survivin
Survivin was regulated by TGF-beta (zeige TGFB1 Proteine) and was found to be highly expressed during mucosal healing following intestinal inflammation
Survivin is a key regulator of gut (zeige GUSB Proteine) tissue integrity by regulating epithelial homeostasis in the stem cell niche.
TGFbetaRI inhibition in an injured adult heart could both stimulate the autocrine/paracrine activity of survivin and inhibit Wnt (zeige WNT2 Proteine) in CPCs to mediate cardioprotection and improve cardiac function.
Survivin is a key gene for regulating squamous cell carcinoma (SCC (zeige CYP11A1 Proteine)) cancer stem cell formation and cancer SCC (zeige CYP11A1 Proteine) development.
In colorectal cancer mice with downregulated expression of survivin, there were higher numbers of apoptotic cells and decreased expression levels of bcl2 (zeige BCL2 Proteine) and ki67 (zeige MKI67 Proteine).
The present studies aim to examine whether and how cilia function (Pkd1 (zeige PKD1 Proteine) or Pkd2 (zeige PKD2 Proteine)) and structure (Tg737 (zeige IFT88 Proteine)) play a role in cystic kidney and aneurysm through survivin downregulation.
Survivin 1 was identified as a key regulator of neurogenesis, vasculo-angiogenesis, hematopoiesis and cardiogenesis.
the Aurora B (zeige AURKB Proteine) chromosome passenger protein complex, including INCENP (zeige INCENP Proteine) and survivin, is regulated during oocyte maturation in Xenopus laevis
This gene is a member of the inhibitor of apoptosis (IAP) gene family, which encode negative regulatory proteins that prevent apoptotic cell death. IAP family members usually contain multiple baculovirus IAP repeat (BIR) domains, but this gene encodes proteins with only a single BIR domain. The encoded proteins also lack a C-terminus RING finger domain. Gene expression is high during fetal development and in most tumors, yet low in adult tissues. Alternatively spliced transcript variants encoding distinct isoforms have been found for this gene.
apoptosis inhibitor survivin
, baculoviral IAP repeat-containing 5
, baculoviral IAP repeat-containing protein 5
, baculoviral IAP repeat-containing 5 (survivin)
, apoptosis inhibitor 4
, survivin variant 3 alpha
, survivin 1
, Survivin 2
, baculoviral IAP repeat-containing 5, gene 2
, baculoviral IAP repeat-containing protein 5.2