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Ncor1 and Ncor2 play essential but distinct roles in zebrafish primitive myelopoiesis
NCoR1 functions as a negative modulator for hepatic de novo fatty acid synthesis and mitochondria energy adaptation, playing distinct roles in regeneration or carcinogenesis
Liver-Specific Ablation of NCoR1 Induces Hepatic Steatosis and Does Not Prevent Hypothyroidism-Induced Hypercholesterolemia.
the nuclear receptor NCoR1 suppresses Bim1 to inhibit negative selection and promote thymocyte survival.
Loss of NCOR1 is associated with Thyroid Cancer.
These studies support a model in which NCOR1/2 mediates direct Retinoic acid-dependent repression of Fgf8 in caudal progenitors in order to control somitogenesis.
demonstrate that the binding of HDAC3 (zeige HDAC3 Proteine) to IR nGREs in vivo is mediated through interaction with SMRT/NCoR1
GR SUMOylation site is mandatory for the formation of a GR-small ubiquitin-related modifiers (SUMOs)-SMRT/NCoR1-HDAC3 (zeige HDAC3 Proteine) repressing complex, which is indispensable for NF-kappaB (zeige NFKB1 Proteine)/AP1 (zeige JUN Proteine)-mediated GC-induced tethered indirect transrepression in vitro
dexamethasone, a powerful regulator of metabolism and of adipocyte differentiation, confers this change in NCoR mRNA splicing in cultured adipocytes.
Phosphorylation-mediated recruitment switch of NCoR1 between nuclear receptor subsets provides a mechanism by which corepressors can selectively modulate liver energy metabolism during the fasting-feeding transition
NCOR1 protein levels were significantly reduced.
verexpression of COPS5 (zeige COPS5 Proteine), through its isopeptidase activity, leads to ubiquitination and proteasome-mediated degradation of NCoR, a key corepressor for ERalpha (zeige ESR1 Proteine) and tamoxifen-mediated suppression of ERalpha (zeige ESR1 Proteine) target genes.
the NCOR/HDAC3 (zeige HDAC3 Proteine) complex is a major suppressor of differentiation in rhabdomyosarcoma
Authors previously shown that Nuclear Receptor Corepressor 1 (NCoR) and the thyroid hormone receptor (zeige THRA Proteine) beta1 (TRbeta (zeige TXNRD2 Proteine)) inhibit tumor invasion. Here they show that these molecules repress VEGF-C (zeige VEGFC Proteine) and VEGF-D (zeige Figf Proteine) gene transcription in breast cancer cells, reducing lymphatic vessel density and sentinel lymph node invasion in tumor xenografts.
Nuclear Receptor Corepressor 1 is an important transcriptional regulator that interacts with nuclear receptors and other transcription factors. Recent results have shown the presence of inactivating mutations or deletions of the nuclear receptor corepressor 1 gene in human tumors.
NCOR1 function declines with prostate cancer progression. Reduction in NCOR1 levels causes bicalutamide resistance in LNCaP cells and compromises response to bicalutamide in mouse prostate in vivo
USP44 (zeige USP44 Proteine) contributes to N-CoR functions in regulating gene expression and is required for efficient invasiveness of triple-negative breast cancer cells.
PDCD2 (zeige PDCD2 Proteine) and NCoR1 may act as tumor suppressors in Gastrointestinal stromal tumors cells through the Smad (zeige SMAD1 Proteine) signaling pathway.
Data suggest that complexes of HDAC3-H1.3 with NCOR1 and NCOR2/SMRT accumulate on chromatin in synchronized HeLa cells in late G2 phase and mitosis; deacetylation activity of HDAC3 is activated via phosphorylation of Ser-424 by CK2 only in mitosis.
NCoR depletion enhances cancer cell invasion and increases tumor growth and metastatic potential.
loss of nuclear NCoR results in upregulation of a specific cancer-related genetic signature, and is significantly associated with malignant melanoma progression.
Data provide in vivo evidence for targeted recruitment of N-CoR/SMRT-TBLR1 (zeige TBL1XR1 Proteine) complexes by unliganded thyroid hormone (zeige PTH Proteine) receptors in transcriptional repression during vertebrate development
This gene encodes a protein that mediates ligand-independent transcription repression of thyroid-hormone and retinoic-acid receptors by promoting chromatin condensation and preventing access of the transcription machinery. It is part of a complex which also includes histone deacetylases and transcriptional regulators similar to the yeast protein Sin3p. This gene is located between the Charcot-Marie-Tooth and Smith-Magenis syndrome critical regions on chromosome 17. Alternate splicing results in multiple transcript variants. Pseudogenes of this gene are found on chromosomes 17 and 20.
nuclear receptor corepressor 1
, nuclear receptor co-repressor 1
, retinoid X receptor interacting protein 13
, retinoid X receptor-interacting protein 13
, N-Cor/SMRT corepressor Rip13
, N-Cor/SMRT corepressor, Rip13
, thyroid hormone- and retinoic acid receptor-associated corepressor 1